CMA1, chymase 1, 1215

N. diseases: 157; N. variants: 2
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 Biomarker group BEFREE Cloning and sequencing of the monocarboxylate transporter from mouse Ehrlich Lettré tumour cell confirms its identity as MCT1 and demonstrates that glycosylation is not required for MCT1 function. 8603082 1996
CUI: C0007194
Disease: Hypertrophic Cardiomyopathy
Hypertrophic Cardiomyopathy 		0.010 GeneticVariation disease BEFREE Angiotensin-converting enzyme and heart chymase gene polymorphisms in hypertrophic cardiomyopathy. 8759823 1996
CUI: C4551472
Disease: Hypertrophic obstructive cardiomyopathy
Hypertrophic obstructive cardiomyopathy 		0.010 GeneticVariation disease BEFREE Angiotensin-converting enzyme and heart chymase gene polymorphisms in hypertrophic cardiomyopathy. 8759823 1996
CUI: C0013595
Disease: Eczema
Eczema 		0.050 AlteredExpression disease BEFREE Association between variants of mast cell chymase gene and serum IgE levels in eczema. 9463800 1998
CUI: C0013595
Disease: Eczema
Eczema 		0.050 GeneticVariation disease BEFREE No evidence for an association between a variant of the mast cell chymase gene and atopic dermatitis based on case-control and haplotype-relative-risk analyses. 9748697 1998
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic 		0.030 GeneticVariation disease BEFREE No evidence for an association between a variant of the mast cell chymase gene and atopic dermatitis based on case-control and haplotype-relative-risk analyses. 9748697 1998
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction 		0.020 GeneticVariation disease BEFREE Chymase gene locus is not associated with myocardial infarction and is not linked to heart size or blood pressure. 9794357 1998
CUI: C0018799
Disease: Heart Diseases
Heart Diseases 		0.010 Biomarker group BEFREE The chymase gene is said to be important for the generation of angiotensin II in the heart and therefore is a candidate gene for heart disease. 9794357 1998
CUI: C0155626
Disease: Acute myocardial infarction
Acute myocardial infarction 		0.010 GeneticVariation disease BEFREE However, we were unable to find an association between allelic variants of the chymase gene and acute myocardial infarction or linkage between the chymase gene locus and heart size. 9794357 1998
CUI: C0878544
Disease: Cardiomyopathies
Cardiomyopathies 		0.010 AlteredExpression group BEFREE In the present study we determined the gene organization of a novel hamster chymase (hamster chymase 2) and analysed the expression of chymase 1, chymase 2 and angiotensin-converting enzyme (ACE) in hamster hearts at the terminal stage of cardiomyopathy. 9657983 1998
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.030 GeneticVariation disease BEFREE Angiotensinogen M235T and chymase gene CMA/B polymorphisms are not associated with nephropathy in type II diabetes. 11096141 2000
CUI: C0022658
Disease: Kidney Diseases
Kidney Diseases 		0.010 GeneticVariation group BEFREE Our study provided evidence against an association between angiotensinogen M235T or chymase gene CMA/B polymorphisms and the presence of incipient or overt nephropathy in Caucasian patients with type II diabetes. 11096141 2000
CUI: C0013595
Disease: Eczema
Eczema 		0.050 GeneticVariation disease BEFREE Absence of association between a variant of the mast cell chymase gene and atopic dermatitis in an Italian population. 11173969 2001
CUI: C0011615
Disease: Dermatitis, Atopic
Dermatitis, Atopic 		0.030 GeneticVariation disease BEFREE Absence of association between a variant of the mast cell chymase gene and atopic dermatitis in an Italian population. 11173969 2001
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis 		0.010 GeneticVariation disease BEFREE A chymase gene variant is associated with atherosclerosis in venous coronary artery bypass grafts. 11696688 2001
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis 		0.010 GeneticVariation disease BEFREE A chymase gene variant is associated with atherosclerosis in venous coronary artery bypass grafts. 11696688 2001
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.100 AlteredExpression group BEFREE Carcinoma samples displaying reduced levels of MCT1 were found to express the high affinity glucose transporter, GLUT1, suggesting that there is a switch from butyrate to glucose as an energy source in colonic epithelia during transition to malignancy. 11953883 2002
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.100 AlteredExpression group BEFREE Carcinoma samples displaying reduced levels of MCT1 were found to express the high affinity glucose transporter, GLUT1, suggesting that there is a switch from butyrate to glucose as an energy source in colonic epithelia during transition to malignancy. 11953883 2002
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.030 GeneticVariation disease LHGDN Angiotensin I-converting enzyme and chymase gene polymorphisms - relationship to left ventricular mass in type 2 diabetes patients. 12165749 2002
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.030 GeneticVariation disease BEFREE Angiotensin I-converting enzyme and chymase gene polymorphisms - relationship to left ventricular mass in type 2 diabetes patients. 12165749 2002
CUI: C0007097
Disease: Carcinoma
Carcinoma 		0.020 AlteredExpression group BEFREE Analysis of healthy colonic tissues and carcinomas using immunohistochemistry and Western blotting revealed a significant decline in the expression of MCT1 protein during transition from normality to malignancy. 11953883 2002
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.330 Biomarker group CTD_human Human chymase expression in a mice induces mild hypertension with left ventricular hypertrophy. 14620933 2003
CUI: C0149721
Disease: Left Ventricular Hypertrophy
Left Ventricular Hypertrophy 		0.310 Biomarker disease CTD_human Human chymase expression in a mice induces mild hypertension with left ventricular hypertrophy. 14620933 2003
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.100 PosttranslationalModification disease BEFREE Reduced expression of GNA11 and silencing of MCT1 in human breast cancers. 12759536 2003
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.100 AlteredExpression group BEFREE We examined a diverse panel of lymphoid malignancies for the expression of MCT-1. 12637315 2003