PLIN2, perilipin 2, 123

N. diseases: 100; N. variants: 3
Disease: Fatty Liver ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0015695
Disease: Fatty Liver
Fatty Liver 		0.330 Biomarker disease BEFREE Recent data indicate that Plin2 has an important function in cell metabolism and is involved in several human pathologies, including liver steatosis and Type II diabetes. 30288961 2019
CUI: C0015695
Disease: Fatty Liver
Fatty Liver 		0.330 Biomarker disease BEFREE <i>In vivo</i> ceramide reduction by inhibition of <i>de novo</i> ceramide synthesis reduced PLIN2 and hepatic steatosis in alcohol-fed mice, but only <i>de novo</i> synthesis inhibition, not sphingomyelin hydrolysis, improved glucose tolerance and dyslipidemia. 28864659 2018
CUI: C0015695
Disease: Fatty Liver
Fatty Liver 		0.330 Biomarker disease BEFREE Mice lacking perilipin-2 (Plin2-null) are resistant to obesity, insulin resistance, and fatty liver induced by Western or high-fat diets. 29866659 2018
CUI: C0015695
Disease: Fatty Liver
Fatty Liver 		0.330 Biomarker disease CTD_human Involvement of Toll-like receptor 4 in acetaminophen hepatotoxicity. 16439473 2006