Steatohepatitis
|
0.380 |
AlteredExpression
|
disease |
BEFREE |
Cardiac overexpression of perilipin 2 induces atrial steatosis, connexin 43 remodeling, and atrial fibrillation in aged mice.
|
31661297 |
2019 |
Steatohepatitis
|
0.380 |
Biomarker
|
disease |
BEFREE |
In vitro, CVC inhibited CCL2-induced increases in hepatocyte fatty acid synthase (Fasn) and adipose differentiation-related protein (Adrp), whereas it augmented acyl-coenzyme A oxidase 1 (Acox-1), proliferator-activated receptor gamma co-activator alpha (Pgc1α) and uncoupling protein 2 expression, suggesting mechanisms for attenuated hepatocyte steatosis.
|
30179264 |
2019 |
Steatohepatitis
|
0.380 |
AlteredExpression
|
disease |
BEFREE |
A recent report shows that cardiac overexpression of Plin2 result in massive myocardial steatosis suggesting that Plin2 stabilizes LDs.
|
31061399 |
2019 |
Steatohepatitis
|
0.380 |
Biomarker
|
disease |
BEFREE |
Analyses of the molecular and cellular processes mediating steatosis, inflammation and fibrosis identified differences in total and hepatocyte-specific actions of Plin2 on the mechanisms promoting NAFLD pathophysiology.
|
30536914 |
2019 |
Steatohepatitis
|
0.380 |
Biomarker
|
disease |
BEFREE |
Recent data indicate that Plin2 has an important function in cell metabolism and is involved in several human pathologies, including liver steatosis and Type II diabetes.
|
30288961 |
2019 |
Steatohepatitis
|
0.380 |
Biomarker
|
disease |
BEFREE |
These findings implicate CerS6 as a novel regulator of PLIN2 and suggest that ceramide synthetic enzymes may promote the earliest stage of alcoholic liver disease, alcoholic steatosis.-Williams, B., Correnti, J., Oranu, A., Lin, A., Scott, V., Annoh, M., Beck, J., Furth, E., Mitchell, V., Senkal, C. E., Obeid, L., Carr, R. M. A novel role for ceramide synthase 6 in mouse and human alcoholic steatosis.
|
28864659 |
2018 |
Steatohepatitis
|
0.380 |
Biomarker
|
disease |
BEFREE |
Mice lacking perilipin-2 (Plin2-null) are resistant to obesity, insulin resistance, and fatty liver induced by Western or high-fat diets.
|
29866659 |
2018 |
Steatohepatitis
|
0.380 |
AlteredExpression
|
disease |
BEFREE |
Mice generated through crossing of PLIN2-Tg mice and HSL-Tg mice showed cardiac-specific HSL overexpression and complete lack of steatosis.
|
28851734 |
2017 |
Steatohepatitis
|
0.380 |
Biomarker
|
disease |
CTD_human |
Involvement of Toll-like receptor 4 in acetaminophen hepatotoxicity.
|
16439473 |
2006 |