|
Steatohepatitis
|
0.380 |
AlteredExpression
|
disease |
BEFREE |
Cardiac overexpression of perilipin 2 induces atrial steatosis, connexin 43 remodeling, and atrial fibrillation in aged mice.
|
31661297 |
2019 |
|
Steatohepatitis
|
0.380 |
Biomarker
|
disease |
BEFREE |
In vitro, CVC inhibited CCL2-induced increases in hepatocyte fatty acid synthase (Fasn) and adipose differentiation-related protein (Adrp), whereas it augmented acyl-coenzyme A oxidase 1 (Acox-1), proliferator-activated receptor gamma co-activator alpha (Pgc1α) and uncoupling protein 2 expression, suggesting mechanisms for attenuated hepatocyte steatosis.
|
30179264 |
2019 |
|
Steatohepatitis
|
0.380 |
AlteredExpression
|
disease |
BEFREE |
A recent report shows that cardiac overexpression of Plin2 result in massive myocardial steatosis suggesting that Plin2 stabilizes LDs.
|
31061399 |
2019 |
|
Steatohepatitis
|
0.380 |
Biomarker
|
disease |
BEFREE |
Analyses of the molecular and cellular processes mediating steatosis, inflammation and fibrosis identified differences in total and hepatocyte-specific actions of Plin2 on the mechanisms promoting NAFLD pathophysiology.
|
30536914 |
2019 |
|
Steatohepatitis
|
0.380 |
Biomarker
|
disease |
BEFREE |
Recent data indicate that Plin2 has an important function in cell metabolism and is involved in several human pathologies, including liver steatosis and Type II diabetes.
|
30288961 |
2019 |
|
Steatohepatitis
|
0.380 |
Biomarker
|
disease |
BEFREE |
These findings implicate CerS6 as a novel regulator of PLIN2 and suggest that ceramide synthetic enzymes may promote the earliest stage of alcoholic liver disease, alcoholic steatosis.-Williams, B., Correnti, J., Oranu, A., Lin, A., Scott, V., Annoh, M., Beck, J., Furth, E., Mitchell, V., Senkal, C. E., Obeid, L., Carr, R. M. A novel role for ceramide synthase 6 in mouse and human alcoholic steatosis.
|
28864659 |
2018 |
|
Steatohepatitis
|
0.380 |
Biomarker
|
disease |
BEFREE |
Mice lacking perilipin-2 (Plin2-null) are resistant to obesity, insulin resistance, and fatty liver induced by Western or high-fat diets.
|
29866659 |
2018 |
|
Steatohepatitis
|
0.380 |
AlteredExpression
|
disease |
BEFREE |
Mice generated through crossing of PLIN2-Tg mice and HSL-Tg mice showed cardiac-specific HSL overexpression and complete lack of steatosis.
|
28851734 |
2017 |
|
Steatohepatitis
|
0.380 |
Biomarker
|
disease |
CTD_human |
Involvement of Toll-like receptor 4 in acetaminophen hepatotoxicity.
|
16439473 |
2006 |
|
Fatty Liver
|
0.330 |
Biomarker
|
disease |
BEFREE |
Recent data indicate that Plin2 has an important function in cell metabolism and is involved in several human pathologies, including liver steatosis and Type II diabetes.
|
30288961 |
2019 |
|
Fatty Liver
|
0.330 |
Biomarker
|
disease |
BEFREE |
<i>In vivo</i> ceramide reduction by inhibition of <i>de novo</i> ceramide synthesis reduced PLIN2 and hepatic steatosis in alcohol-fed mice, but only <i>de novo</i> synthesis inhibition, not sphingomyelin hydrolysis, improved glucose tolerance and dyslipidemia.
|
28864659 |
2018 |
|
Fatty Liver
|
0.330 |
Biomarker
|
disease |
BEFREE |
Mice lacking perilipin-2 (Plin2-null) are resistant to obesity, insulin resistance, and fatty liver induced by Western or high-fat diets.
|
29866659 |
2018 |
|
Fatty Liver
|
0.330 |
Biomarker
|
disease |
CTD_human |
Involvement of Toll-like receptor 4 in acetaminophen hepatotoxicity.
|
16439473 |
2006 |
|
Liver Cirrhosis, Experimental
|
0.300 |
Biomarker
|
disease |
CTD_human |
Systems level analysis and identification of pathways and networks associated with liver fibrosis.
|
25380136 |
2014 |
|
Malignant neoplasm of stomach
|
0.300 |
Biomarker
|
disease |
CTD_human |
Methylation status of the 32 randomly selected and 16 potential tumor-related genes was analyzed in 10 primary gastric cancers, and 42 genes (ABHD9, ADFP, ALDH1A3, ANXA5, AREG, BDNF, BMP7, CAV1, CDH2, CLDN3, CTSL, EEF1A2, F2R, FADS1, FSD1, FST, FYN, GPR54, GREM1, IGFBP3, IGFBP7, IRS2, KISS1, MARK1, MLF1, MSX1, MTSS1, NT5E, PAX6, PLAGL1, PLAU, PPIC, RBP4, RORA, SCRN1, TBX3, TFAP2C, TNFSF9, ULBP2, WIF1, ZNF177 and ZNF559) were methylated in at least one primary gastric cancer.
|
16367923 |
2006 |
|
Stomach Neoplasms
|
0.300 |
Biomarker
|
group |
CTD_human |
Chemical genomic screening for methylation-silenced genes in gastric cancer cell lines using 5-aza-2'-deoxycytidine treatment and oligonucleotide microarray.
|
16367923 |
2006 |
|
Hereditary Diffuse Gastric Cancer
|
0.300 |
Biomarker
|
disease |
CTD_human |
Chemical genomic screening for methylation-silenced genes in gastric cancer cell lines using 5-aza-2'-deoxycytidine treatment and oligonucleotide microarray.
|
16367923 |
2006 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Urine PLIN-2 concentrations were roughly proportional to tumor size (Pearson coefficient 0.59).
|
31668633 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In summary, perilipin 1 is a promising marker for the differential diagnosis of liposarcomas from other soft tissue sarcomas, whereas perilipin 2 correlates negatively with tumor grade and may be therapeutically useful.
|
31125552 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Immunohistochemistry for CK10, p16, adipophilin and ki67 was performed on 7 cases of each type of tumor.
|
31584883 |
2019 |
|
Systolic Pressure
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Trans-ethnic association study of blood pressure determinants in over 750,000 individuals.
|
30578418 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Immunohistochemistry revealed a positive reaction for cytokeratin 1 (CK1) in tumor cells of Bowen disease and a negative reaction for CK1 in tumor cells with the sebaceous differentiation, whereas immunohistochemistry revealed no apparent adipophilin-positive granules in tumor nests of Bowen disease compared with the prominent staining of adipophilin in tumor nests with sebaceous differentiation.
|
29742561 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The immunoreactivity of adipophilin and gross cystic disease fluid protein (GCDFP)-15 was investigated to determine the origin of the tumor.
|
30178542 |
2018 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The expression and distribution of adipophilin were compared between WOS-positive and WOS-negative lesions and among tumors classified by histologic type and depth of invasion.
|
29307996 |
2017 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Furthermore, we found that CEBPA-mediated upregulation of PLIN2 expression promotes tumor growth via GSK3 and Wnt/β-catenin signaling <i>in vivo</i>.
|
28560057 |
2017 |