|
Asthma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Chemokine signaling through CCR3 is a key regulatory pathway for eosinophil recruitment into tissues associated with allergic inflammation and asthma.
|
29778505 |
2019 |
|
Asthma
|
0.400 |
Biomarker
|
disease |
BEFREE |
CCR3 is the cognate receptor for major human eosinophil chemoattractants from the eotaxin family of proteins that are elevated in asthma and correlate with disease severity.
|
29423947 |
2018 |
|
Asthma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The eotaxin receptor CCR3 was expressed at high levels on submucosal endothelial cells in patients and a murine model of asthma.
|
26810221 |
2016 |
|
Asthma
|
0.400 |
Biomarker
|
disease |
BEFREE |
A CCL chemokine-derived peptide (CDIP-2) exerts anti-inflammatory activity via CCR1, CCR2 and CCR3 chemokine receptors: Implications as a potential therapeutic treatment of asthma.
|
24560857 |
2014 |
|
Asthma
|
0.400 |
GeneticVariation
|
disease |
GWASDB |
Association between ORMDL3, IL1RL1 and a deletion on chromosome 17q21 with asthma risk in Australia.
|
21150878 |
2011 |
|
Asthma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Chemokines ligands of CCR3 including eotaxin/CC chemokine ligand 11 (CCL11) may contribute to the pathogenesis of asthma.
|
20214667 |
2010 |
|
Asthma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Therefore, we decided to analyze the regulation of CCR3 by IFN-gamma in asthmatics and to characterize the dependence of this process on immunoglobulin E (IgE) levels.
|
18849613 |
2009 |
|
Asthma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
CCL26-targeted siRNA treatment of alveolar type II cells decreases expression of CCR3-binding chemokines and reduces eosinophil migration: implications in asthma therapy.
|
19203252 |
2009 |
|
Asthma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
But, we observed that the A-384G polymorphism of Eotaxin 1 gene and T51C polymorphism of CCR3 gene are not associated with asthma.
|
17845580 |
2007 |
|
Asthma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Inhalation of IL-5 significantly decreased CD34(+)/IL-5Ralpha mRNA(+) cells within the bronchial mucosa and the percentage of CD34(+) cells that were CCR3(+) within the bone marrow of atopic asthmatic, but not control, volunteers.
|
17581195 |
2007 |
|
Asthma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Although polymorphisms in CCR3 were not associated with asthma susceptibility, the CCR3 haplotype ht2 showed a negative gene dose effect on the eosinophil count (P = .003-.009).
|
17983872 |
2007 |
|
Asthma
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
But, we observed that the A-384G polymorphism of Eotaxin 1 gene and T51C polymorphism of CCR3 gene are not associated with asthma.
|
17845580 |
2007 |
|
Asthma
|
0.400 |
Biomarker
|
disease |
RGD |
Topical inhibition of CCR3 expression, using an AS-ODN, could represent a novel approach for the treatment of asthma.
|
16978084 |
2006 |
|
Asthma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Epithelial immunostaining for CCR3 was stronger in bronchial biopsies of asthmatics displaying marked inflammatory changes than in nondiseased samples.
|
16920975 |
2006 |
|
Asthma
|
0.400 |
Biomarker
|
disease |
BEFREE |
The mean percentage of CD4 + CCR3 + cells in asthma patients was significantly higher but that of CD4 + CCR5 + cells was lower when compared with those in healthy subjects respectively.
|
17361521 |
2006 |
|
Asthma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
These results may suggest that eotaxin could be involved in the increased smooth muscle mass observed in asthmatics through the activation of CCR3.
|
16081847 |
2005 |
|
Asthma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Chemokine (C-C motif) ligand 24 (CCL24, eotaxin-2) is a CC chemokine that recruits and activates cells bearing the CC chemokine receptor 3, which play a major role in asthma.
|
15744457 |
2005 |
|
Asthma
|
0.400 |
Biomarker
|
disease |
BEFREE |
In contrast, spleens of sensitized and challenged Tg mice contained increased numbers of CD4(+)CCR3(+) cells producing more Th2-type cytokines (IL-4, IL-5, and IL-13), which were associated with increased airway hyperreactivity.
|
12874248 |
2003 |
|
Asthma
|
0.400 |
Biomarker
|
disease |
BEFREE |
We have now detected CCR3 immunoreactivity on epithelial cells in biopsies of patients with asthma and other respiratory diseases.
|
11160184 |
2001 |
|
Asthma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, a significant association between asthma and CCR3 T51C polymorphism localized on chromosome 3p21 was found.
|
11307756 |
2001 |
|
Asthma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In conclusions, through the modification of the expression of CCR-3 in peripheral blood leukocytes from atopic asthmatics, IFN-gamma could exert a beneficial effect in patients with asthma, regulating the migration of some inflammatory cells involved in the pathogenesis of the disease.
|
11699731 |
2001 |
|
Asthma
|
0.400 |
Biomarker
|
disease |
BEFREE |
The purpose of this study was to enumerate CD34(+) cell numbers in blood and bone marrow from atopic asthmatics and control subjects and to test the hypothesis that there is an increased bone marrow pool of CCR3(+) eosinophils in patients with atopic asthma, as compared with control subjects.
|
9893192 |
1999 |
|
Asthma
|
0.400 |
Biomarker
|
disease |
BEFREE |
We examined the expression of eotaxin, eotaxin-2, RANTES, monocyte chemoattractant protein-3 (MCP-3), MCP-4, and CCR3 in the bronchial mucosa from atopic (AA) and nonatopic (intrinsic; NAA) asthmatics and compared our findings with atopic (AC) and nonatopic nonasthmatic controls (NC).
|
10570327 |
1999 |