CCR3, C-C motif chemokine receptor 3, 1232

N. diseases: 149; N. variants: 16
Disease: HIV-1 infection ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C2363741
Disease: HIV-1 infection
HIV-1 infection 		0.050 AlteredExpression disease BEFREE Our results support the hypothesis that opioids play a significant role in the susceptibility of the CNS to HIV-1 infection and subsequent encephalopathy by inhibiting local production of HIV-1-protective chemokines (IL-8 and macrophage-inflammatory protein-1beta) and enhancing expression of HIV-1 entry coreceptor genes (CCR3, CCR5, and CXCR2) within the CNS. 12244149 2002
CUI: C2363741
Disease: HIV-1 infection
HIV-1 infection 		0.050 AlteredExpression disease BEFREE Incubation of basophils with Tat protein upregulates the surface expression of the CCR3 receptor, a co-receptor of HIV-1 infection. 11292016 2001
CUI: C2363741
Disease: HIV-1 infection
HIV-1 infection 		0.050 Biomarker disease BEFREE Monoclonal antibodies (MAb) to CD4, CXCR4, CCR5, and CCR3 were tested for their ability to block VSV(HIV-1) infection of syncytiotrophoblast cells. 11468721 2001
CUI: C2363741
Disease: HIV-1 infection
HIV-1 infection 		0.050 Biomarker disease BEFREE Thus, CCR5, not CCR3, is an essential receptor for HIV-1 infection of monocytes. 9525662 1998
CUI: C2363741
Disease: HIV-1 infection
HIV-1 infection 		0.050 Biomarker disease BEFREE The CCR3 ligand, eotaxin, and an anti-CCR3 antibody inhibited HIV-1 infection of microglia, as did MIP-1beta, which is a CCR5 ligand. 9024664 1997