|
Dengue Fever
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The sequences of infections which produced a higher risk of dengue fever upon secondary infection are: DEN1 followed by DEN2; DEN1 followed by DEN4; DEN2 followed by DEN3; and DEN4 followed by DEN3.
|
31253823 |
2019 |
|
Dengue Fever
|
0.100 |
Biomarker
|
disease |
BEFREE |
Dengue is one of the most important and widespread viral infection comprises 4 related serotypes (DEN-1, 2, 3, and 4).
|
29247706 |
2018 |
|
Dengue Fever
|
0.100 |
Biomarker
|
disease |
BEFREE |
Several other vaccine approaches have been developed including live attenuated chimeric dengue vaccines (DENVax and LAV Delta 30), DEN protein subunit V180 vaccine (DEN1-80E) and DENV DNA vaccines.
|
28281864 |
2017 |
|
Dengue Fever
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
There are five dengue viruses, called serotypes (DEN-1, DEN-2, DEN-3, DEN-4, and DEN-5), which belong to the Flaviviridae family and are transmitted to humans through infected mosquito bites, with the main vector the Aedes aegypti mosquito (Linnaeus, 1762).Studies performed with Ae. aegypti, aimed at their identification and analysis of their population structure, are fundamental to improve understanding of the epidemiology of dengue, as well for the definition of strategic actions that reduce the transmission of this disease.
|
28560571 |
2017 |
|
Dengue Fever
|
0.100 |
Biomarker
|
disease |
BEFREE |
The DENV assay results, in agreement with the serological tests and sequencing analysis, showed that the pathogen resulting in the DF explosion in Guangdong in 2006 belonged to DEN-1.
|
19018028 |
2008 |
|
Dengue Fever
|
0.100 |
Biomarker
|
disease |
BEFREE |
The competitor provides a suitable internal control useful to quantify viral RNA from all four dengue virus (DEN 1-4) serotypes.
|
18597860 |
2008 |
|
Dengue Fever
|
0.100 |
Biomarker
|
disease |
BEFREE |
The results show that 45 people were positive for dengue-specific IgM (27 males and 18 females), while RT-PCR detected dengue viral RNA in 12 patients, 3 identified as DEN-1 and 9 as DEN-2.
|
17642533 |
2007 |
|
Dengue Fever
|
0.100 |
Biomarker
|
disease |
BEFREE |
Predominance of DEN-1 in 1998 and DEN-3 re-introduction and predominance in 2001-2003 coincided with outbreaks.
|
17160279 |
2006 |
|
Dengue Fever
|
0.100 |
Biomarker
|
disease |
BEFREE |
To find fast and reliable methods to diagnose dengue in the early phase of the disease, patient acute-phase sera were investigated for the presence of dengue-specific immunoglobulin M (IgM) antibodies by enzyme-linked immunosorbent assay (ELISA) and also for dengue serotype (DEN-1 to DEN-4)-specific RNA by different PCR assays.
|
15956408 |
2005 |
|
Dengue Fever
|
0.100 |
Biomarker
|
disease |
BEFREE |
In 2001, an autochthonous case of dual viremia, resulting from naturally acquired dengue virus DEN-1 and DEN-2 infections was detected during the dengue outbreak that occurred in Barretos, a city with about 105,000 inhabitants in the North region of São Paulo State.
|
12751316 |
2003 |
|
Dengue Fever
|
0.100 |
Biomarker
|
disease |
BEFREE |
Conversely, HLA-B*51 was associated with the development of DHF in patients with secondary infections, and HLA-B*52 was associated with DF in patients with secondary DEN-1 and DEN-2 infections.
|
12472660 |
2002 |
|
Dengue Fever
|
0.100 |
Biomarker
|
disease |
BEFREE |
When sera were tested for plaque-reduction neutralizing antibodies to DEN 1-4 viruses, nearly 85% had antibodies to two or more DEN serotypes.
|
11561700 |
2001 |
|
Dengue Fever
|
0.100 |
Biomarker
|
disease |
BEFREE |
Using a serotype-specific monoclonal antibody (MAb) of dengue virus type 1 (DEN-1), 15F3-1, we identified the B-cell epitope of DEN-1 from a random peptide library displayed on phage.
|
11230414 |
2001 |
|
Dengue Fever
|
0.100 |
Biomarker
|
disease |
BEFREE |
During the observation period, primary dengue infection rates were DEN 1 = 4.8%, DEN 2 = 7.7%, DEN 3 = 4.2%, and DEN 4 = 3.4%, while two or more dengue infections occurred in 6.7% of the study population.
|
10497982 |
1999 |
|
Dengue Fever
|
0.100 |
Biomarker
|
disease |
BEFREE |
A split decomposition analysis of dengue (DEN) virus gene sequences revealed extensive networked evolution, indicative of recombination, among DEN-1 strains but not within serotypes DEN-2, DEN-3, or DEN-4.
|
10331266 |
1999 |
|
Dengue Fever
|
0.100 |
Biomarker
|
disease |
BEFREE |
Maximum nucleotide sequence variation was 6.9% and 4.9% for DEN-1 and DEN-4 viruses, respectively.
|
9049396 |
1995 |
|
Dengue Fever
|
0.100 |
Biomarker
|
disease |
BEFREE |
Four recombinant vaccinia viruses expressing different portions of the dengue type 1 virus (DEN-1) genome (C-prM-E-NS1-NS2A-NS2B; prM-E; prM-E-NS1-NS2A-NS2B; or NS1-NS2A) were constructed in order to establish the most immunogenic configuration of DEN-1 proteins.
|
8165861 |
1994 |
|
Severe Dengue
|
0.030 |
Biomarker
|
disease |
BEFREE |
These results indicate that DEN-1 and DEN-3 induce DHF in both primary and secondary infections, and suggest that DEN-2 and DEN-4 in Thailand are less likely to cause DHF in primary infections.
|
15962557 |
2005 |
|
Severe Dengue
|
0.030 |
Biomarker
|
disease |
BEFREE |
The recent severe DEN-1 epidemic in French Polynesia in 2001, with an incidence rate of 16% and more than 45% of the cases with dengue hemorrhagic fever/dengue shock syndrome among 1,400 hospitalized children and eight fatalities, led us to study this new circulating strain.
|
15516646 |
2004 |
|
Severe Dengue
|
0.030 |
Biomarker
|
disease |
BEFREE |
Conversely, HLA-B*51 was associated with the development of DHF in patients with secondary infections, and HLA-B*52 was associated with DF in patients with secondary DEN-1 and DEN-2 infections.
|
12472660 |
2002 |
|
Liver carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
These findings may be important in tumorigenesis, as we find decreased NEDP1 levels in hepatocellular carcinoma with concomitant accumulation of NEDD8 conjugates.
|
31577950 |
2019 |
|
Virus Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Dengue is one of the most important and widespread viral infection comprises 4 related serotypes (DEN-1, 2, 3, and 4).
|
29247706 |
2018 |
|
Malignant neoplasm of lung
|
0.010 |
Biomarker
|
disease |
BEFREE |
The replication efficiency of DENV in lung cancer cells from high to low is: DEN-2 (dengue virus type-2), DEN-3, DEN-4 and DEN-1.
|
17416433 |
2007 |
|
Carcinoma of lung
|
0.010 |
Biomarker
|
disease |
BEFREE |
The replication efficiency of DENV in lung cancer cells from high to low is: DEN-2 (dengue virus type-2), DEN-3, DEN-4 and DEN-1.
|
17416433 |
2007 |
|
Primary malignant neoplasm of lung
|
0.010 |
Biomarker
|
disease |
BEFREE |
The replication efficiency of DENV in lung cancer cells from high to low is: DEN-2 (dengue virus type-2), DEN-3, DEN-4 and DEN-1.
|
17416433 |
2007 |