|
Hepatitis C
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
This study suggests the lack of association of SDF-1 3'A, MCP-1 (-2518), CCR5-Delta32 polymorphisms with death and HCC occurrence in cirrhotic HCV-infected patients.
|
18205260 |
2008 |
|
Hepatitis C
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Considering the number of Δ32 allele carriers and non-carriers, no statistically significant differences (p > 0.05) between the groups were observed, suggesting that the CCR5Δ32 variant does not influence the susceptibility to HCV infection, HCV/HIV co-infection, or HCV-related diseases in individuals from southern Brazil.
|
29408489 |
2018 |
|
Hepatitis C
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Expression of CCR5 was detectable in areas of inflammation and fibrogenesis in liver biopsies of patients with HCV/HIV co-infection.
|
19736361 |
2010 |
|
Hepatitis C
|
0.400 |
Biomarker
|
disease |
BEFREE |
We evaluated the effect of CCR5 blockade or knockdown on HCV replication in Huh7.5JFH1 cells.
|
31661521 |
2019 |
|
Hepatitis C
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
The increased prevalence of CCR5-Delta32 homozygosity associated with increased viral loads in patients with chronic hepatitis C suggests that the CCR5-Delta32 mutation may be an adverse host factor in hepatitis C.
|
12055576 |
2002 |
|
Hepatitis C
|
0.400 |
Biomarker
|
disease |
BEFREE |
Six single nucleotide polymorphisms and a 32 bp deletion in the genes coding for CCR3, CCR2 and CCR5 (which are all located in a cluster on chromosome 3) were investigated in 465 consecutively recruited patients infected with HCV and 370 matched controls.
|
15086398 |
2004 |
|
Hepatitis C
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our review indicated no consistent evidence of increased risk of susceptibility to hepatitis C virus infection or multiple sclerosis among individuals with CCR5-delta32 mutation, and suggested treatment with a CCR5 inhibitor is unlikely to have related adverse effects.
|
17503665 |
2007 |
|
Hepatitis C
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, we found no increased frequency of the CCR5 Delta32 polymorphism in two independent cohorts of patients with HCV infection but without hemophilia as the main risk factor for infection.
|
14673528 |
2004 |
|
Hepatitis C
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A total of 283 women, all exposed to HCV genotype 1b from a single donor, and including those who had spontaneously cleared the virus and those chronically infected, were genotyped for CCR2, CCR5, and RANTES polymorphisms.
|
15863470 |
2005 |
|
Hepatitis C
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Here, we analysed proliferation, IFN-gamma and IL-4 secretion (ELISpot) induced by the HCV antigens core, NS3, NS4, and NS5a in 21 anti-HCV-positive haemophiliac patients in relationship to their CCR5 genotypes (CCR5 wildtype n = 10, CCR5-Delta32 heterozygous n = 5 and CCR5-Delta32 homozygous n = 6).
|
19811439 |
2009 |
|
Hepatitis C
|
0.400 |
Biomarker
|
disease |
BEFREE |
Although best recognized for its function as a major co-receptor for cell entry of HIV, CC chemokine receptor 5 (CCR5) has also been implicated in the pathogenesis of HCV infection.
|
23936229 |
2013 |
|
Hepatitis C
|
0.400 |
Biomarker
|
disease |
BEFREE |
This proviral effect of HIV and gp120 on HCV replication is neutralized by antibodies to CCR5 or CXCR4.
|
18325393 |
2008 |
|
Hepatitis C
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our results do not support the hypothesis that the CCR5-Delta32 mutant allele is a risk factor for hepatitis C virus infection.
|
15802968 |
2005 |
|
Hepatitis C
|
0.400 |
Biomarker
|
disease |
CTD_human |
|
|
|
|
Hepatitis C
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
An elevated frequency of the CCR5-Delta32 mutation in German patients with hepatitis C with viremia has been reported.
|
16721228 |
2006 |
|
Hepatitis C
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Here, we determine the influence of copy number variation on the susceptibility and disease severity in hepatitis C virus (HCV) infection, investigating copy number variants (CNVs) of the chemokine CCL3L1 gene, which encodes a potent CCR5 ligand.
|
20044164 |
2010 |
|
Hepatitis C
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The results of logistic regression analysis showed that the distribution of CCR5 gene polymorphism in the case group was statistically different from that in the control group (P<0.05), which had a statistical correlation with the renal damage due to HCV-related cryoglobulinemia (P<0.05).
|
30214525 |
2018 |
|
Hepatitis C
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The increased prevalence of CCR5-Delta32 homozygosity associated with increased viral loads in patients with chronic hepatitis C suggests that the CCR5-Delta32 mutation may be an adverse host factor in hepatitis C.
|
12055576 |
2002 |
|
Hepatitis C
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We explored a possible link between a CCR5 32-base deletion (CCR5delta32), resulting in the expression of a non-functioning receptor, and clinical outcomes of HCV infection.
|
25191700 |
2014 |
|
Hepatitis C
|
0.400 |
Biomarker
|
disease |
BEFREE |
The role of CC chemokine receptor 5 (CCR5) and its ligand CCL5 on the pathogenesis of HIV infection has been well studied but not for HCV infection.
|
27304910 |
2016 |
|
Hepatitis C
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our results seem to indicate that the CCR5-Delta 32 and CCR2-V64I polymorphisms are not related to the response to HCV infection, histological damage and outcome of infection in our cohort of Spanish HCV patients.
|
15230854 |
2004 |
|
Hepatitis C
|
0.400 |
Biomarker
|
disease |
BEFREE |
Polymorphisms in genes encoding for the chemokines stromal cell-derived factor-1 (SDF-1)/CXCL12, monocyte chemotactic protein-1 (MCP-1)/CCL2, or for the chemokine receptors, CC chemokine receptor 5 (CCR5) or CC chemokine receptor 2 (CCR2) have been associated with the progression of hepatitis C virus-related liver injury and with various cancer development.
|
17413295 |
2007 |
|
Hepatitis C
|
0.400 |
Biomarker
|
disease |
BEFREE |
These observations argue strongly against a role of CCR5 for susceptibility to HCV infection or response to combination therapy.
|
12865070 |
2003 |
|
Hepatitis C
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A low viral load, hepatitis C virus (HCV) serotype 2 and CCR5 59029G/G were significantly associated with a higher probability of a sustained response (p < 0.01, p < 0.05, p < 0.05, respectively).
|
15192276 |
2004 |
|
Hepatitis C
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Response rates to interferon-alpha monotherapy are reduced in hepatitis C virus (HCV)-infected patients carrying the CCR5-Delta32 mutation.
|
12873822 |
2003 |