|
Hepatitis C
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Here, we investigated the relative genetic contributions of the CCR5Δ32 deletion and the IL28B rs12979860 polymorphisms to spontaneous clearance of hepatitis C in a single-source outbreak.
|
21703201 |
2011 |
|
Hepatitis C
|
0.400 |
Biomarker
|
disease |
BEFREE |
This fact provides the unique opportunity to study the role of the CCR5 receptor in chronic hepatitis C infection by comparing immune responses between HCV infected CCR5-Delta32 carriers and CCR5 wild-type patients.
|
15128728 |
2004 |
|
Hepatitis C
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We explored the influence of the major CCR5 promoter or coding region variants as haplotypes and genotypes in a cohort of 250 chronically infected HCV patients receiving combined interferon/ ribavirin therapy.
|
12403355 |
2002 |
|
Hepatitis C
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A recent study proposed a 32-base pair deletion in the CC-chemokine receptor 5 (CCR5) gene (CCR5-Δ32) interacting with the IL28B polymorphisms to influence spontaneous HCV clearance.
|
23594959 |
2014 |
|
Hepatitis C
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Here, we analysed proliferation, IFN-gamma and IL-4 secretion (ELISpot) induced by the HCV antigens core, NS3, NS4, and NS5a in 21 anti-HCV-positive haemophiliac patients in relationship to their CCR5 genotypes (CCR5 wildtype n = 10, CCR5-n32 heterozygous n = 5 and CCR5-n32 homozygous n = 6).
|
19172482 |
2009 |
|
Hepatitis C
|
0.400 |
Biomarker
|
disease |
BEFREE |
The 2007 workshop, held on 12-16 June, proved particularly notable for its exploration of resistance to two new antiretroviral classes, integrase inhibitors and CCR5 antagonists, as well as to agents that control hepatitis C virus (HCV) infection.
|
18505183 |
2008 |
|
Hepatitis C
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
Here, we analysed proliferation, IFN-gamma and IL-4 secretion (ELISpot) induced by the HCV antigens core, NS3, NS4, and NS5a in 21 anti-HCV-positive haemophiliac patients in relationship to their CCR5 genotypes (CCR5 wildtype n = 10, CCR5-n32 heterozygous n = 5 and CCR5-n32 homozygous n = 6).
|
19172482 |
2009 |
|
Hepatitis C
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We compared 220 schistosomiasis patients (S group) and 190 patients with HCV and schistosomiasis (HCV/S group) for the presence of the CCR5Δ32 mutation.
|
23515570 |
2013 |
|
Hepatitis C
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The HCV protective allele TT was associated with decreased likelihood of HIV-1 infection in male intravenous drug users [odds ratio (OR): 0.3; P = 0.006], and this association was not modified by the genotype of CCR5.
|
26372394 |
2015 |
|
West Nile Fever
|
0.360 |
Biomarker
|
disease |
BEFREE |
Thus, CCR5 deficiency is a strong and consistent risk factor for symptomatic WNV infection in the United States.
|
18179388 |
2008 |
|
West Nile Fever
|
0.360 |
Biomarker
|
disease |
CTD_human |
|
|
|
|
West Nile Fever
|
0.360 |
Biomarker
|
disease |
BEFREE |
Thus, CCR5 may function normally to limit disease due to WNV infection in humans.
|
20025530 |
2010 |
|
West Nile Fever
|
0.360 |
GeneticVariation
|
disease |
BEFREE |
Chemokine receptor 5 (CCR5) is hypothesized to drive the lymphocyte migration to central nervous system in flavivirus encephalitis, and the non-functional CCR5Δ32 genetic variant was identified as a risk factor of a West Nile virus infection and of tick-borne encephalitis (TBE).
|
26906062 |
2016 |
|
West Nile Fever
|
0.360 |
Biomarker
|
disease |
BEFREE |
CCR5: no longer a "good for nothing" gene--chemokine control of West Nile virus infection.
|
16753343 |
2006 |
|
West Nile Fever
|
0.360 |
Biomarker
|
disease |
BEFREE |
We conclude that CCR5 mediates resistance to symptomatic WNV infection.
|
16418398 |
2006 |
|
West Nile Fever
|
0.360 |
Biomarker
|
disease |
BEFREE |
A new study suggests a link between CCR5Delta32 (a common mutant allele of the chemokine and HIV receptor CCR5) and fatal WNV infection.
|
16750369 |
2006 |
|
Schizophrenia
|
0.330 |
GeneticVariation
|
disease |
BEFREE |
Alternatively, the CCR5 32-bp deletion allele may act as a modifier by delaying the onset of schizophrenia without affecting the disease susceptibility.
|
16513874 |
2006 |
|
Schizophrenia
|
0.330 |
Biomarker
|
disease |
PSYGENET |
Alternatively, the CCR5 32-bp deletion allele may act as a modifier by delaying the onset of schizophrenia without affecting the disease susceptibility.
|
16513874 |
2006 |
|
Schizophrenia
|
0.330 |
GeneticVariation
|
disease |
LHGDN |
The CCR5 32-bp deletion allele is rare in a Chinese population.
|
18295459 |
2008 |
|
Schizophrenia
|
0.330 |
GeneticVariation
|
disease |
BEFREE |
Conclusions Our findings suggest that CCR5-A55029G polymorphisms and CCR2-V64I WT: CCR5-A55029G A and CCR2-V64I 64I: CCR5-A55029G A haplotypes might have association with schizophrenia pathogenesis.
|
26906930 |
2016 |
|
Dermatitis, Atopic
|
0.300 |
Biomarker
|
disease |
CTD_human |
Peroxisome proliferator-activated receptor alpha regulates skin inflammation and humoral response in atopic dermatitis.
|
18249437 |
2008 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.300 |
Biomarker
|
disease |
RGD |
Immunoregulatory role of nitric oxide in Kilham rat virus-induced autoimmune diabetes in DR-BB rats.
|
15240727 |
2004 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
The frequencies of the CCR5-delta32 and SDF1-3'A (801G-->A in the 3' untranslated region) variants were similar in 208 unrelated Caucasian patients with type 1 diabetes and in 120 Caucasian control subjects.
|
11334429 |
2001 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
The PBMCs of patients with newly diagnosed but not with longstanding type 1 diabetes showed reduced expression of the Th1-associated chemokine receptors CCR5 (P < 0.001 vs. control subjects) and CXCR3 (P < 0.002 vs. control subjects).
|
12145160 |
2002 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
CCR5-Δ32 gene polymorphism is associated with retinopathy in patients with type 1 diabetes.
|
27619405 |
2017 |