|
Malignant neoplasm of lung
|
0.190 |
GeneticVariation
|
disease |
BEFREE |
As a result, 15 SNPs on or near 12 genes and one miRNA with strong evidence of association with lung cancer risk were identified, including TERT (rs2736098), CHRNA3 (rs1051730), AGPHD1 (rs8034191), CLPTM1L (rs401681 and rs402710), BAT3 (rs3117582), TRNAA (rs4324798), ERCC2 (Lys751Gln), miR-146a2 (rs2910164), CYP1B1 (Arg48Gly), GSTM1 (null/present), SOD2 (C47T), IL-10 (-592C/A and -819C/T), and TP53 (intron 6).
|
29110844 |
2017 |
|
Malignant neoplasm of lung
|
0.190 |
GeneticVariation
|
disease |
BEFREE |
In summary, CHRNA3 rs1051730 (G > A) and AGPHD1 rs8034191 (A > G) were more susceptible to lung cancers than noncarriers.
|
27072204 |
2016 |
|
Malignant neoplasm of lung
|
0.190 |
GeneticVariation
|
disease |
BEFREE |
Meta-analysis of the association between the rs8034191 polymorphism in AGPHD1 and lung cancer risk.
|
25854352 |
2015 |
|
Malignant neoplasm of lung
|
0.190 |
GeneticVariation
|
disease |
BEFREE |
Genetic association between AGPHD1 variant and lung cancer risk.
|
25074529 |
2014 |
|
Malignant neoplasm of lung
|
0.190 |
GeneticVariation
|
disease |
GWASDB |
Influence of common genetic variation on lung cancer risk: meta-analysis of 14 900 cases and 29 485 controls.
|
22899653 |
2012 |
|
Malignant neoplasm of lung
|
0.190 |
GeneticVariation
|
disease |
BEFREE |
Our findings demonstrated that CHRNA3 gene rs1051730-A allele and AGPHD1 gene rs8034191-T allele might be risk-conferring factors for the development of lung cancer in Caucasians, but not in East-Asians.
|
22701590 |
2012 |
|
Malignant neoplasm of lung
|
0.190 |
GeneticVariation
|
disease |
BEFREE |
In a nested case-control study comparing 746 lung cancer cases to 1,477 controls, all of whom were non-Hispanic white smokers in the β-Carotene and Retinol Efficacy Trial, we examined whether lung cancer risk is associated with single nucleotide polymorphisms (SNPs) tagging the AGPHD1, CHRNA5, CHRNA3, and CHRNB4 genes and whether such risk is modified by diet and other characteristics.
|
21229299 |
2011 |
|
Malignant neoplasm of lung
|
0.190 |
Biomarker
|
disease |
BEFREE |
Three single nucleotide polymorphisms (SNPs) of CHRNA3, CHRNA5 and LOC123688 increase lung cancer risk.
|
19733931 |
2010 |
|
Malignant neoplasm of lung
|
0.190 |
GeneticVariation
|
disease |
BEFREE |
Associations of SNPs in LOC123688 (rs10519203; odds ratio [OR] = 1.60, 95% confidence interval [CI] = 1.25 to 2.05, P = .00016), CHRNA5 (rs2036527; OR = 1.67, 95% CI = 1.26 to 2.21, P = .00031), and CHRNA3 (rs1051730; OR = 1.81, 95% CI = 1.26 to 2.59, P = .00137) genes with lung cancer risk reached Bonferroni-corrected levels of statistical significance (all statistical tests were two-sided).
|
20554942 |
2010 |
|
Malignant neoplasm of lung
|
0.190 |
GeneticVariation
|
disease |
GWASDB |
Deciphering the impact of common genetic variation on lung cancer risk: a genome-wide association study.
|
19654303 |
2009 |
|
Malignant neoplasm of lung
|
0.190 |
Biomarker
|
disease |
BEFREE |
We identified associations between common sequence variants at 15q24-25.1 (that spanned LOC123688 [a hypothetical gene], PSMA4, CHRNA3, CHRNA5, and CHRNB4) and lung cancer.
|
18780872 |
2008 |
|
Malignant neoplasm of lung
|
0.190 |
GeneticVariation
|
disease |
GWASDB |
Familial aggregation of common sequence variants on 15q24-25.1 in lung cancer.
|
18780872 |
2008 |
|
Malignant neoplasm of lung
|
0.190 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1.
|
18385676 |
2008 |
|
Malignant neoplasm of lung
|
0.190 |
GeneticVariation
|
disease |
GWASDB |
Lung cancer susceptibility locus at 5p15.33.
|
18978790 |
2008 |
|
Malignant neoplasm of lung
|
0.190 |
GeneticVariation
|
disease |
GWASDB |
Common 5p15.33 and 6p21.33 variants influence lung cancer risk.
|
18978787 |
2008 |
|
Malignant neoplasm of lung
|
0.190 |
GeneticVariation
|
disease |
GWASDB |
A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25.
|
18385738 |
2008 |