|
Abscess
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Both genetic deletion and topical pharmacological BLT1 antagonism restored inflammatory response and abscess formation, followed by a reduction in the bacterial load and lesion area in the diabetic mice.
|
30185672 |
2018 |
|
Abscess
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
We found that LTB4 is produced in areas near the abscess and BLT1 deficient mice are unable to form an abscess, elicit neutrophil chemotaxis, generation of neutrophil and monocyte chemokines, as well as reactive oxygen species-dependent bacterial clearance.
|
30102746 |
2018 |
|
Acute infectious disease
|
0.010 |
Biomarker
|
group |
BEFREE |
Here we characterize the phenotype and function of human peripheral blood BLT1(+) T cells in health and illustrate their involvement in asthma and acute infection.
|
16179368 |
2006 |
|
Acute pancreatitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Blockade of BLT1 by LY293111 attenuated the severity of AP, decreased neutrophil reverse transendothelial cell migration (rTEM) into the circulation and alleviated the severity of ALI.
|
29482159 |
2018 |
|
Adenocarcinoma
|
0.010 |
Biomarker
|
group |
BEFREE |
NIH:Swiss outbred and Apc(Min/+) mice were infected with CR (10(8) CFU); BLT1(-/-)Apc(Min/+) mice, azoxymethane (AOM)/dextran sodium sulfate (DSS)-treated mice and de-identified human adenocarcinoma samples were the models of colon cancer.
|
25486432 |
2015 |
|
Age related macular degeneration
|
0.010 |
Biomarker
|
disease |
BEFREE |
Here, we demonstrate that leukotriene B4 (LTB4) receptor 1 (BLT1) promotes laser-induced choroidal neovascularization (CNV) in a mouse model for wet-type AMD.
|
30232269 |
2018 |
|
Allergic sensitization
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Chimeric mice were established to evaluate the contribution of BLT1 expression in nonimmune cell to allergic sensitization.
|
30390302 |
2019 |
|
Alopecia
|
0.010 |
Biomarker
|
disease |
BEFREE |
<b>Results:</b> We showed imaging of infiltrating immunocytes in BLT mice that spontaneously developed a graft-versus-host-like condition, characterized by alopecia and blepharitis.
|
28209904 |
2017 |
|
anaphylaxis
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Targeted disruption of the leukotriene B(4) receptor in mice reveals its role in inflammation and platelet-activating factor-induced anaphylaxis.
|
10934231 |
2000 |
|
Aortic Aneurysm
|
0.010 |
Biomarker
|
disease |
BEFREE |
Inhibited aortic aneurysm formation in BLT1-deficient mice.
|
17579092 |
2007 |
|
Aortic aneurysm without mention of rupture NOS
|
0.010 |
Biomarker
|
disease |
BEFREE |
Inhibited aortic aneurysm formation in BLT1-deficient mice.
|
17579092 |
2007 |
|
Aortic Aneurysm, Abdominal
|
0.010 |
Biomarker
|
disease |
BEFREE |
Thus, we have shown that BLT1 contributes to the frequency and size of abdominal aortic aneurysms in mice and that BLT1 deletion in turn inhibits proinflammatory circuits and enzymes that modulate vessel wall integrity.
|
17579092 |
2007 |
|
Arteriosclerosis
|
0.040 |
Biomarker
|
disease |
BEFREE |
The effects of LTB4 in atherosclerosis are likely mediated through the high-affinity BLT-1 and the low-affinity BLT-2 receptors.
|
14656734 |
2004 |
|
Arteriosclerosis
|
0.040 |
Biomarker
|
disease |
BEFREE |
Mice deficient in leukotriene B<sub>4</sub> receptor1 (BLT1) are protected in inflammatory disease models of arthritis, asthma and atherosclerosis.
|
29209564 |
2017 |
|
Arteriosclerosis
|
0.040 |
Biomarker
|
disease |
BEFREE |
Expression of BLT1 was confirmed in type 1 helper T cells, type 2 helper T cells, type 17 helper T cells, effector CD8(+) T cells, dendritic cells and osteoclasts in addition to granulocytes, eosinophils and macrophages, and BLT1-deficient mice showed greatly reduced phenotypes in models of various inflammatory diseases, such as peritonitis, bronchial asthma, rheumatoid arthritis, atherosclerosis and osteoporosis.
|
25480980 |
2015 |
|
Arteriosclerosis
|
0.040 |
Biomarker
|
disease |
BEFREE |
These findings extend the role of BLT1 to a critical complication of vascular disease and underscore its potential as a target for intervention in modulating multiple pathologies related to atherosclerosis.
|
17579092 |
2007 |
|
Arthritis
|
0.040 |
Biomarker
|
disease |
BEFREE |
Studies in mouse models demonstrated an important role for the high-affinity leukotriene B(4) receptor BLT1 in arthritis, atherosclerosis, and asthma.
|
20656922 |
2010 |
|
Arthritis
|
0.040 |
Biomarker
|
disease |
BEFREE |
Many studies have implicated that blockade of leukotriene B4 (LTB<sub>4</sub>) and its high affinity receptor BLT1 dramatically suppress arthritis in animal models.
|
29042029 |
2017 |
|
Arthritis
|
0.040 |
Biomarker
|
disease |
BEFREE |
Compelling evidence suggests that this C5a/C5aR1-LTB<sub>4</sub>/BLT1 axis driving granulocyte recruitment in arthritis may represent a more generalizable biological principle critically regulating effector cell recruitment in other IgG autoantibody-induced diseases, such as in pemphigoid diseases.
|
29602515 |
2018 |
|
Arthritis
|
0.040 |
Biomarker
|
disease |
BEFREE |
Mice deficient in leukotriene B<sub>4</sub> receptor1 (BLT1) are protected in inflammatory disease models of arthritis, asthma and atherosclerosis.
|
29209564 |
2017 |
|
Asthma
|
0.080 |
Biomarker
|
disease |
BEFREE |
Both BLT(1) and BLT(2) were higher in asthmatics compared to healthy controls, while CysLT(1) and CysLT(2) did not differ.
|
21596548 |
2011 |
|
Asthma
|
0.080 |
Biomarker
|
disease |
LHGDN |
The leukotriene B4-BLT1 pathway is an important target for the treatment of bronchial asthma.
|
17075244 |
2006 |
|
Asthma
|
0.080 |
Biomarker
|
disease |
BEFREE |
The importance of the LTB4-BLT1 pathway in asthma pathogenesis has extensive experimental support and findings, albeit limited, from clinical samples.
|
29042028 |
2017 |
|
Asthma
|
0.080 |
Biomarker
|
disease |
BEFREE |
Unlike BLT1, a high-affinity receptor for LTB(4), no clear physiological function has yet been identified for BLT2, especially with regard to the pathogenesis of asthma.
|
19448154 |
2010 |
|
Asthma
|
0.080 |
Biomarker
|
disease |
BEFREE |
Although rare in the peripheral blood of healthy individuals, BLT1(+) T cells are markedly increased in frequency in the peripheral blood in response to acute Epstein-Barr virus (EBV) infection and moderately increased in the airways of asymptomatic allergic asthmatics.
|
16179368 |
2006 |