|
Inflammation
|
0.310 |
Biomarker
|
phenotype |
LHGDN |
These data are the first to show both a functional and an essential role for BLT1 in allergen-mediated CD8+ T(EFF) recruitment into the lung and development of AHR and airway inflammation.
|
15814727 |
2005 |
|
Inflammation
|
0.310 |
Biomarker
|
phenotype |
CTD_human |
Targeted disruption of the leukotriene B(4) receptor in mice reveals its role in inflammation and platelet-activating factor-induced anaphylaxis.
|
10934231 |
2000 |
|
Liver diseases
|
0.300 |
Biomarker
|
group |
CTD_human |
Blood gene expression markers to detect and distinguish target organ toxicity.
|
19784758 |
2010 |
|
Liver Dysfunction
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Blood gene expression markers to detect and distinguish target organ toxicity.
|
19784758 |
2010 |
|
anaphylaxis
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Targeted disruption of the leukotriene B(4) receptor in mice reveals its role in inflammation and platelet-activating factor-induced anaphylaxis.
|
10934231 |
2000 |
|
Nephrosclerosis
|
0.200 |
Biomarker
|
disease |
CTD_mouse |
Role of the high-affinity leukotriene B4 receptor signaling in fibrosis after unilateral ureteral obstruction in mice.
|
30818366 |
2019 |
|
Hepatitis, Toxic
|
0.200 |
Biomarker
|
disease |
CTD_mouse |
Dioxin-induced increase in leukotriene B4 biosynthesis through the aryl hydrocarbon receptor and its relevance to hepatotoxicity owing to neutrophil infiltration.
|
28487374 |
2017 |
|
Drug-Induced Liver Disease
|
0.200 |
Biomarker
|
phenotype |
CTD_mouse |
Dioxin-induced increase in leukotriene B4 biosynthesis through the aryl hydrocarbon receptor and its relevance to hepatotoxicity owing to neutrophil infiltration.
|
28487374 |
2017 |
|
Hepatitis, Drug-Induced
|
0.200 |
Biomarker
|
disease |
CTD_mouse |
Dioxin-induced increase in leukotriene B4 biosynthesis through the aryl hydrocarbon receptor and its relevance to hepatotoxicity owing to neutrophil infiltration.
|
28487374 |
2017 |
|
Drug-Induced Acute Liver Injury
|
0.200 |
Biomarker
|
disease |
CTD_mouse |
Dioxin-induced increase in leukotriene B4 biosynthesis through the aryl hydrocarbon receptor and its relevance to hepatotoxicity owing to neutrophil infiltration.
|
28487374 |
2017 |
|
Chemical and Drug Induced Liver Injury
|
0.200 |
Biomarker
|
disease |
CTD_mouse |
Dioxin-induced increase in leukotriene B4 biosynthesis through the aryl hydrocarbon receptor and its relevance to hepatotoxicity owing to neutrophil infiltration.
|
28487374 |
2017 |
|
Chemically-Induced Liver Toxicity
|
0.200 |
Biomarker
|
disease |
CTD_mouse |
Dioxin-induced increase in leukotriene B4 biosynthesis through the aryl hydrocarbon receptor and its relevance to hepatotoxicity owing to neutrophil infiltration.
|
28487374 |
2017 |
|
Carotid Artery Diseases
|
0.200 |
Biomarker
|
group |
RGD |
Leukotriene B4 signaling through NF-kappaB-dependent BLT1 receptors on vascular smooth muscle cells in atherosclerosis and intimal hyperplasia.
|
16293697 |
2005 |
|
Asthma
|
0.080 |
Biomarker
|
disease |
BEFREE |
The importance of the LTB4-BLT1 pathway in asthma pathogenesis has extensive experimental support and findings, albeit limited, from clinical samples.
|
29042028 |
2017 |
|
Asthma
|
0.080 |
Biomarker
|
disease |
BEFREE |
Expression of BLT1 was confirmed in type 1 helper T cells, type 2 helper T cells, type 17 helper T cells, effector CD8(+) T cells, dendritic cells and osteoclasts in addition to granulocytes, eosinophils and macrophages, and BLT1-deficient mice showed greatly reduced phenotypes in models of various inflammatory diseases, such as peritonitis, bronchial asthma, rheumatoid arthritis, atherosclerosis and osteoporosis.
|
25480980 |
2015 |
|
Asthma
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
Six LTB4R single nucleotide polymorphisms (SNPs) were genotyped in 370 Caucasian asthma families and 299 Adult Asthma Individuals (n=1877 total) and were evaluated for association with asthma and severity (BTS) outcome measures using Family Based Association Test, linear regression and chi square.
|
23167751 |
2012 |
|
Asthma
|
0.080 |
Biomarker
|
disease |
BEFREE |
Both BLT(1) and BLT(2) were higher in asthmatics compared to healthy controls, while CysLT(1) and CysLT(2) did not differ.
|
21596548 |
2011 |
|
Asthma
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
These data suggest that polymorphisms spanning ALOX5AP, LTA4H and the LTB4R locus are not major determinants of baseline lung function in smokers, but provide tentative evidence for LTA4H rs1978331C (intron 11) in determining baseline FEV1 and FEV1/FVC ratio in Caucasian Smokers in addition to our previously identified role in asthma susceptibility.
|
22206291 |
2011 |
|
Asthma
|
0.080 |
Biomarker
|
disease |
BEFREE |
Unlike BLT1, a high-affinity receptor for LTB(4), no clear physiological function has yet been identified for BLT2, especially with regard to the pathogenesis of asthma.
|
19448154 |
2010 |
|
Asthma
|
0.080 |
Biomarker
|
disease |
LHGDN |
The leukotriene B4-BLT1 pathway is an important target for the treatment of bronchial asthma.
|
17075244 |
2006 |
|
Asthma
|
0.080 |
Biomarker
|
disease |
BEFREE |
Although rare in the peripheral blood of healthy individuals, BLT1(+) T cells are markedly increased in frequency in the peripheral blood in response to acute Epstein-Barr virus (EBV) infection and moderately increased in the airways of asymptomatic allergic asthmatics.
|
16179368 |
2006 |
|
Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
In this study, we wanted to investigate the impact of human umbilical cord-derived MSCs (hUC-MSCs) on tumor growth in humanized mice generated by the human adoptive transfer of PBMCs or the cotransplantation of hematopoietic stem cells and human thymic tissue (human BLT [Hu-BLT]).
|
31578272 |
2019 |
|
Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
Super-charged NK cells inhibit growth and progression of stem-like/poorly differentiated oral tumors <i>in vivo</i> in humanized BLT mice; effect on tumor differentiation and response to chemotherapeutic drugs.
|
29721395 |
2018 |
|
Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
Several in vivo mouse models including humanized-BLT mice have been used to study the biology and significance of NK cells in selection/differentiation of stem-like tumors within the context of a reconstituted human immune system.
|
29653339 |
2018 |
|
Neoplasms
|
0.060 |
Biomarker
|
group |
BEFREE |
Diesel exhaust particle promotes tumor lung metastasis via the induction of BLT1-mediated neutrophilic lung inflammation.
|
29884308 |
2018 |