LTB4R, leukotriene B4 receptor, 1241

N. diseases: 107; N. variants: 0
Disease: Arthritis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0003864
Disease: Arthritis
Arthritis 		0.040 Biomarker disease BEFREE Compelling evidence suggests that this C5a/C5aR1-LTB<sub>4</sub>/BLT1 axis driving granulocyte recruitment in arthritis may represent a more generalizable biological principle critically regulating effector cell recruitment in other IgG autoantibody-induced diseases, such as in pemphigoid diseases. 29602515 2018
CUI: C0003864
Disease: Arthritis
Arthritis 		0.040 Biomarker disease BEFREE Many studies have implicated that blockade of leukotriene B4 (LTB<sub>4</sub>) and its high affinity receptor BLT1 dramatically suppress arthritis in animal models. 29042029 2017
CUI: C0003864
Disease: Arthritis
Arthritis 		0.040 Biomarker disease BEFREE Mice deficient in leukotriene B<sub>4</sub> receptor1 (BLT1) are protected in inflammatory disease models of arthritis, asthma and atherosclerosis. 29209564 2017
CUI: C0003864
Disease: Arthritis
Arthritis 		0.040 Biomarker disease BEFREE Studies in mouse models demonstrated an important role for the high-affinity leukotriene B(4) receptor BLT1 in arthritis, atherosclerosis, and asthma. 20656922 2010