MSI2, musashi RNA binding protein 2, 124540

N. diseases: 80; N. variants: 13
Disease: Blast Phase ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0005699
Disease: Blast Phase
Blast Phase 		0.030 Biomarker disease BEFREE As an upstream regulator of BCAT1 expression, we identified Musashi2 (MSI2), an oncogenic RNA binding protein that is required for blast crisis CML. 28514443 2017
CUI: C0005699
Disease: Blast Phase
Blast Phase 		0.030 AlteredExpression disease BEFREE Genetic loss of MSI2 leads to down-regulation of the FLT3 receptor in both AML and BC-CML cells and concomitant impairment of clonogenic growth potential. 28107692 2017
CUI: C0005699
Disease: Blast Phase
Blast Phase 		0.030 AlteredExpression disease BEFREE Notably, loss of Msi2 restores Numb expression and significantly impairs the development and propagation of blast crisis CML in vitro and in vivo. 20639863 2010