|
Liver carcinoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
Heat shock protein 20 (HSPB6) regulates TNF-α-induced intracellular signaling pathway in human hepatocellular carcinoma cells.
|
25447820 |
2015 |
|
Liver carcinoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
With regard to hepatocellular carcinoma (HCC) cells, we previously reported that phosphorylated HSP20 plays a suppressive role in transforming growth factor (TGF)-α-induced cell migration and invasion.
|
28456666 |
2017 |
|
Liver carcinoma
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
These findings strongly suggest that HSP20 directly associates with PI3K and suppresses its activity in HCC, resulting in the inhibition of the AKT pathway, and subsequently decreasing the growth of HCC.
|
24223153 |
2013 |
|
Liver carcinoma
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
The aim of this study was to investigate the clinicopathological and immunohistochemical (including VEGF, Akt, HSP70, and HSP20 expression) factors that affect the overall and disease-free survival of HCC patients following surgical resection.
|
29318189 |
2017 |
|
Liver carcinoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
Therefore, in the present study, we investigated whether HSP20 is implicated in HCC cell migration and the invasion using human HCC-derived HuH7 cells.
|
27046040 |
2016 |
|
Neuromuscular inhibition
|
0.030 |
Biomarker
|
disease |
BEFREE |
Moreover, accumulating evidence has implicated HSPB6 as a key mediator of diverse vital physiological processes, such as smooth muscle relaxation, platelet aggregation.
|
29132139 |
2017 |
|
Neuromuscular inhibition
|
0.030 |
Biomarker
|
disease |
BEFREE |
Phosphorylation of the small heat shock protein, HSPB6, within its intrinsically disordered N-terminal domain activates its interaction with 14-3-3, ultimately triggering smooth muscle relaxation.
|
28089448 |
2017 |
|
Neuromuscular inhibition
|
0.030 |
Biomarker
|
disease |
BEFREE |
Recently, Hsp20 and its phosphorylation have been implicated in multiple physiological and pathophysiological processes including smooth muscle relaxation, platelet aggregation, exercise training, myocardial infarction, atherosclerosis, insulin resistance and Alzheimer's disease.
|
20869365 |
2011 |
|
Alzheimer's Disease
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Up-regulation of Hsp20 protein levels in response to amyloid fibril formation is considered a key protective response against the onset of Alzheimer's disease (AD).
|
24859569 |
2014 |
|
Alzheimer's Disease
|
0.020 |
Biomarker
|
disease |
BEFREE |
Recently, Hsp20 and its phosphorylation have been implicated in multiple physiological and pathophysiological processes including smooth muscle relaxation, platelet aggregation, exercise training, myocardial infarction, atherosclerosis, insulin resistance and Alzheimer's disease.
|
20869365 |
2011 |
|
Asthma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Heat shock protein 20 (HSP20), which is a member of the small heat shock protein family, is known to participate in many pathological processes, such as asthma, intimal hyperplasia, and insulin resistance.
|
25187324 |
2015 |
|
Colorectal Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Therefore, HSP20 may have value as a prognostic tumor marker and its overexpression might be a novel strategy for CRC therapy.
|
25187324 |
2015 |
|
Epilepsy
|
0.010 |
Biomarker
|
disease |
BEFREE |
In this investigation, we explored whether HspB6 played a positive effect on epilepsy with the involvement of the cyclic adenosine monophosphate-protein kinase A (cAMP-PKA) pathway.
|
30511325 |
2019 |
|
Multiple Sclerosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Western blotting revealed significantly higher levels of HSPB1, HSPB6 and HSPB8 in MS and control spinal cord compared to brain tissues.
|
30014472 |
2018 |
|
Myocardial Infarction
|
0.010 |
Biomarker
|
disease |
BEFREE |
Next, these mice were divided into three groups, namely Blank group (healthy mice), Model group (mouse models of myocardial infarction), and HSP20 group (mouse models of myocardial infarction transfected with lentivirus to overexpress HSP20).
|
31210321 |
2019 |
|
Neuroblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Using both conventional MTT end-point assays and novel real time measurement of cell impedance, we show that Hsp20 protects human neuroblastoma SH-SY5Y cells from the neurotoxic effects of Aβ.
|
24859569 |
2014 |
|
Subarachnoid Hemorrhage
|
0.010 |
Biomarker
|
disease |
BEFREE |
The most widely studied HSPs in SAH are HSP70, haeme oxygenase-1 (HO-1), HSP20 and HSP27.
|
31273911 |
2019 |
|
Cerebral Amyloid Angiopathy
|
0.010 |
Biomarker
|
disease |
BEFREE |
Small heat shock proteins Hsp20 and HspB2/B3 co-localize with Abeta deposition in senile plaques and cerebral amyloid angiopathy in Alzheimer's disease brains, respectively.
|
16635482 |
2006 |
|
Myocardial Ischemia
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
Therefore, phosphorylation of Hsp20 at serine 16 may represent a potential therapeutic target in ischemic heart disease.
|
19850943 |
2009 |
|
Senile Plaques
|
0.010 |
Biomarker
|
disease |
BEFREE |
Small heat shock proteins Hsp20 and HspB2/B3 co-localize with Abeta deposition in senile plaques and cerebral amyloid angiopathy in Alzheimer's disease brains, respectively.
|
16635482 |
2006 |
|
Impaired cognition
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, reducing hippocampal and cortical expression of HSP20 with an intracerebral injection of pSUPER hsp20 small interfering RNA significantly diminished the PE-induced overexpression of hippocampal and cortical BDNF and the TrkB ratio and also reversed the beneficial effect of PE in reducing neurotrauma and the cognitive deficits.
|
29574629 |
2018 |
|
Human papilloma virus infection
|
0.010 |
Biomarker
|
disease |
BEFREE |
The recombinant E7 and Hsp27 proteins showed higher efficiency than Hsp20 and Hp91 for detection of individuals exposed to HPV infections (p < 0.05).
|
30755156 |
2019 |
|
Central neuroblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Using both conventional MTT end-point assays and novel real time measurement of cell impedance, we show that Hsp20 protects human neuroblastoma SH-SY5Y cells from the neurotoxic effects of Aβ.
|
24859569 |
2014 |
|
Cardiomyopathy, Familial Idiopathic
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We identified a human mutant of HSPB6 (HSPB6<sup>S10F</sup>) exclusively present in dilated cardiomyopathy (DCM) patients.
|
29157081 |
2018 |
|
Childhood Neuroblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Using both conventional MTT end-point assays and novel real time measurement of cell impedance, we show that Hsp20 protects human neuroblastoma SH-SY5Y cells from the neurotoxic effects of Aβ.
|
24859569 |
2014 |