|
Heart Diseases
|
0.320 |
Biomarker
|
group |
BEFREE |
This mini-review highlights exciting findings in animal models and human patients, with special emphasis on the potential salutary effects of Hsp20 in heart disease.
|
20869365 |
2011 |
|
Heart Diseases
|
0.320 |
Therapeutic
|
group |
CTD_human |
Heat shock protein 20 interacting with phosphorylated Akt reduces doxorubicin-triggered oxidative stress and cardiotoxicity.
|
18948619 |
2008 |
|
Heart Diseases
|
0.320 |
GeneticVariation
|
group |
BEFREE |
We identified a C59T substitution in the human Hsp20 gene in one patient and three individuals without heart disease.
|
18790732 |
2008 |
|
Drug toxicity
|
0.300 |
Therapeutic
|
group |
CTD_human |
Heat shock protein 20 interacting with phosphorylated Akt reduces doxorubicin-triggered oxidative stress and cardiotoxicity.
|
18948619 |
2008 |
|
Adverse reaction to drug
|
0.300 |
Therapeutic
|
group |
CTD_human |
Heat shock protein 20 interacting with phosphorylated Akt reduces doxorubicin-triggered oxidative stress and cardiotoxicity.
|
18948619 |
2008 |
|
Liver carcinoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
With regard to hepatocellular carcinoma (HCC) cells, we previously reported that phosphorylated HSP20 plays a suppressive role in transforming growth factor (TGF)-α-induced cell migration and invasion.
|
28456666 |
2017 |
|
Liver carcinoma
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
The aim of this study was to investigate the clinicopathological and immunohistochemical (including VEGF, Akt, HSP70, and HSP20 expression) factors that affect the overall and disease-free survival of HCC patients following surgical resection.
|
29318189 |
2017 |
|
Liver carcinoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
Therefore, in the present study, we investigated whether HSP20 is implicated in HCC cell migration and the invasion using human HCC-derived HuH7 cells.
|
27046040 |
2016 |
|
Liver carcinoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
Heat shock protein 20 (HSPB6) regulates TNF-α-induced intracellular signaling pathway in human hepatocellular carcinoma cells.
|
25447820 |
2015 |
|
Liver carcinoma
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
These findings strongly suggest that HSP20 directly associates with PI3K and suppresses its activity in HCC, resulting in the inhibition of the AKT pathway, and subsequently decreasing the growth of HCC.
|
24223153 |
2013 |
|
Neuromuscular inhibition
|
0.030 |
Biomarker
|
disease |
BEFREE |
Moreover, accumulating evidence has implicated HSPB6 as a key mediator of diverse vital physiological processes, such as smooth muscle relaxation, platelet aggregation.
|
29132139 |
2017 |
|
Neuromuscular inhibition
|
0.030 |
Biomarker
|
disease |
BEFREE |
Phosphorylation of the small heat shock protein, HSPB6, within its intrinsically disordered N-terminal domain activates its interaction with 14-3-3, ultimately triggering smooth muscle relaxation.
|
28089448 |
2017 |
|
Tumor Cell Invasion
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
With regard to hepatocellular carcinoma (HCC) cells, we previously reported that phosphorylated HSP20 plays a suppressive role in transforming growth factor (TGF)-α-induced cell migration and invasion.
|
28456666 |
2017 |
|
Tumor Cell Invasion
|
0.030 |
AlteredExpression
|
phenotype |
BEFREE |
Phospho-mimic-HSP20 overexpression reduced the migration and invasion compared with unphosphorylated HSP20 overexpression.
|
27046040 |
2016 |
|
Tumor Cell Invasion
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
Together, all this data support a role for Hsp20 in parasite invasion and gliding motility.
|
22902747 |
2012 |
|
Neuromuscular inhibition
|
0.030 |
Biomarker
|
disease |
BEFREE |
Recently, Hsp20 and its phosphorylation have been implicated in multiple physiological and pathophysiological processes including smooth muscle relaxation, platelet aggregation, exercise training, myocardial infarction, atherosclerosis, insulin resistance and Alzheimer's disease.
|
20869365 |
2011 |
|
Cardiomyopathy, Dilated
|
0.020 |
GeneticVariation
|
group |
BEFREE |
We identified a human mutant of HSPB6 (HSPB6<sup>S10F</sup>) exclusively present in dilated cardiomyopathy (DCM) patients.
|
29157081 |
2018 |
|
Cardiomyopathies
|
0.020 |
GeneticVariation
|
group |
BEFREE |
In this study, we investigated the functional significance of a novel human Hsp20 mutation (S10F) in peripartum cardiomyopathy.
|
29761889 |
2018 |
|
Cardiomyopathies
|
0.020 |
Biomarker
|
group |
BEFREE |
Furthermore, Ser10 appears to be crucial for the protective effects of HSPB6 and transversion of this amino acid to Phe contributes to cardiomyopathy.
|
29157081 |
2018 |
|
Alzheimer's Disease
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Up-regulation of Hsp20 protein levels in response to amyloid fibril formation is considered a key protective response against the onset of Alzheimer's disease (AD).
|
24859569 |
2014 |
|
Alzheimer's Disease
|
0.020 |
Biomarker
|
disease |
BEFREE |
Recently, Hsp20 and its phosphorylation have been implicated in multiple physiological and pathophysiological processes including smooth muscle relaxation, platelet aggregation, exercise training, myocardial infarction, atherosclerosis, insulin resistance and Alzheimer's disease.
|
20869365 |
2011 |
|
Cardiomyopathy, Dilated
|
0.020 |
GeneticVariation
|
group |
BEFREE |
To determine whether genetic variants exist in human Hsp20, which may modify these beneficial effects, we sequenced the coding region of the Hsp20 gene in 1347 patients suffering from dilated cardiomyopathy and 744 subjects with no heart disease.
|
18790732 |
2008 |
|
Epilepsy
|
0.010 |
Biomarker
|
disease |
BEFREE |
In this investigation, we explored whether HspB6 played a positive effect on epilepsy with the involvement of the cyclic adenosine monophosphate-protein kinase A (cAMP-PKA) pathway.
|
30511325 |
2019 |
|
Herpes Simplex Infections
|
0.010 |
Biomarker
|
group |
BEFREE |
Generally, Hsp20 was identified as a novel anti-HCV, anti-HSV and anti-HIV agent, but Hsp27 was efficient in the suppression of HSV infection.
|
31362669 |
2019 |
|
Myocardial Infarction
|
0.010 |
Biomarker
|
disease |
BEFREE |
Next, these mice were divided into three groups, namely Blank group (healthy mice), Model group (mouse models of myocardial infarction), and HSP20 group (mouse models of myocardial infarction transfected with lentivirus to overexpress HSP20).
|
31210321 |
2019 |