CNR1, cannabinoid receptor 1, 1268

N. diseases: 393; N. variants: 21
Disease: Cognition Disorders ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0009241
Disease: Cognition Disorders
Cognition Disorders 		0.040 Biomarker group BEFREE Our results identify CB1R as a novel druggable target potentially relevant for the improvement of cognitive deficits associated with Down syndrome. 30685352 2019
CUI: C0009241
Disease: Cognition Disorders
Cognition Disorders 		0.040 Biomarker group BEFREE Cannabinoid CB1 receptors (CB<sub>1</sub>R) and serotonergic 2A receptors (5HT<sub>2A</sub>R) form heteromers in the brain of mice where they mediate the cognitive deficits produced by delta-9-tetrahydrocannabinol. 29294249 2018
CUI: C0009241
Disease: Cognition Disorders
Cognition Disorders 		0.040 AlteredExpression group BEFREE Studies from preclinical animal models indicate that sustained activation of CB1 receptor signaling is a major contributing factor for the onset of cognitive deficits associated to chronic cannabis use, in particular within the working memory and decision-making domains. 28414051 2017
CUI: C0009241
Disease: Cognition Disorders
Cognition Disorders 		0.040 GeneticVariation group BEFREE Cannabinoid receptor 1 gene polymorphisms and marijuana misuse interactions on white matter and cognitive deficits in schizophrenia. 21420833 2011