Depressive disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The present study aimed to clarify whether CNR1rs1049353, CNR1 AAT triplet repeat, and CNR2rs2501432 polymorphisms confer higher risk for depressive disorder.Literature from PubMed, Medline, Embase, Scopus, Cochrance Library, and Wanfang databases was searched (up to August 20, 2018).
|
31725603 |
2019 |
Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
However, serious adverse effects such as depression and suicidality led to the withdrawal of rimonabant (and almost all other CB1R antagonists/inverse agonists) from clinical trials worldwide in 2008.
|
31549358 |
2019 |
Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Because the psychotropic effects and abuse liability of cannabis prevent its therapeutic application in depression and anxiety states, we decided to investigate the effects of the combination of ineffective doses of cannabinoid CB1 receptor agonist arachidonylcyclopropylamide (ACPA) and β-carbolines on anxiety- and depression-related behaviors in male NMRI mice.
|
30797851 |
2019 |
Depressive disorder
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
These results indicate that rTMS can be used as an antidepressive therapy for juvenile depression at least partly mediated by increasing hippocampal 2-AG and CB1 receptor expression levels.
|
29987693 |
2018 |
Depressive disorder
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Pharmacological activation of cannabinoid receptor 1 (CB1R) or blockade of αCaMKII successfully restored LTD in the LHb in an animal model of depression.
|
28700932 |
2017 |
Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Although CB1R inhibition may cause adverse psychiatric effects including depression and anxiety, the investigation of the role of peripheral CB1R on weight loss and related metabolic parameters are urgently needed.
|
28492810 |
2017 |
Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Indeed, CB1 receptors are all distributed in depression associated neuroanatomical structures and neural circuits.
|
29441900 |
2017 |
Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
The first hypothesis is that deficient CB1R-mediated signaling results in symptoms that mimic those seen in depression.
|
24180398 |
2014 |
Depressive disorder
|
0.400 |
Biomarker
|
disease |
PSYGENET |
Rimonabant is a potent cannabinoid receptor1 (CB1) receptor antagonist with wide therapeutic use as an antiobesity drug that has been withdrawn due to side effects in the form of depression and suicidal attacks.
|
25371528 |
2014 |
Depressive disorder
|
0.400 |
Biomarker
|
disease |
PSYGENET |
The first hypothesis is that deficient CB1R-mediated signaling results in symptoms that mimic those seen in depression.
|
24180398 |
2014 |
Depressive disorder
|
0.400 |
Biomarker
|
disease |
PSYGENET |
Exposure to chronic mild stress (CMS), a model of depression, produces downregulation of the cannabinoid 1 (CB1) receptor in the hippocampus of male rats.
|
24035826 |
2013 |
Depressive disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Given the evidence for the role of the endocannabinoid system in the pathogenesis of depression as well as in the mediation of antidepressant drug effects, the aim of this study was to analyze genetic variability in the endocannabinoid system genes (CNR1, CNR2 and FAAH genes) and their role in clinical response (at week 4) and remission (at week 12) in SSRI (citalopram) treatment in a sample of 154 depressive outpatients, all of Spanish origin.
|
22826533 |
2012 |
Depressive disorder
|
0.400 |
Biomarker
|
disease |
PSYGENET |
Given the evidence for the role of the endocannabinoid system in the pathogenesis of depression as well as in the mediation of antidepressant drug effects, the aim of this study was to analyze genetic variability in the endocannabinoid system genes (CNR1, CNR2 and FAAH genes) and their role in clinical response (at week 4) and remission (at week 12) in SSRI (citalopram) treatment in a sample of 154 depressive outpatients, all of Spanish origin.
|
22826533 |
2012 |
Depressive disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
To examine whether a synonymous polymorphism, rs1049353, in exon 4 of the gene encoding the human endocannabinoid receptor (CNR1) moderates the effect of self-reported childhood physical abuse on lifetime anhedonia and depression and to replicate this interaction in an independent sample.
|
22393204 |
2012 |
Depressive disorder
|
0.400 |
Biomarker
|
disease |
PSYGENET |
In the NEWMOOD cohort polymorphisms of the genes of the serotonin transporter, 5-HT1A, 5-HT1B and 5-HT2A and endocannabinoid CB1 receptors, tryptophan hydroxylase, CREB1, BDNF and GIRK provide evidence for the involvement of these genes in the development of depression.
|
23269207 |
2012 |
Depressive disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, current depression scores significantly associated with CNR1 haplotypes but this effect diminished after covariation for recent life events, suggesting a gene x environment interaction.
|
19242408 |
2009 |
Depressive disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
This analysis provides preliminary support for a role of CNR1 gene variation in depression and anxiety, potentially mediated by subcortical hypo-responsiveness to social reward stimuli.
|
18579347 |
2008 |
Depressive disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
For this reason, we have investigated whether there is a genetic risk factor for depression in PD linked to the polymorphisms of CB1 receptor gene.
|
15668727 |
2005 |