|
Alcoholic Intoxication, Chronic
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations.
|
30940813 |
2019 |
|
Alcoholic Intoxication, Chronic
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The interactions of religious involvement with ADH1B-rs2066702, ADH1C-rs698, and ADH4-rs1042364 were significantly associated with maximum drinks and alcohol dependence symptoms.
|
27172571 |
2016 |
|
Alcoholic Intoxication, Chronic
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Rs1800759 (previously known to be associated to AD) and CpG cg12011299 (distance: 37 bp) are both located in alcohol dehydrogenase (ADH) 4 gene (ADH4) promoter region.
|
24889829 |
2014 |
|
Alcoholic Intoxication, Chronic
|
0.500 |
Biomarker
|
disease |
PSYGENET |
Rs1800759 (previously known to be associated to AD) and CpG cg12011299 (distance: 37 bp) are both located in alcohol dehydrogenase (ADH) 4 gene (ADH4) promoter region.
|
24889829 |
2014 |
|
Alcoholic Intoxication, Chronic
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study of alcohol dependence:significant findings in African- and European-Americans including novel risk loci.
|
24166409 |
2014 |
|
Alcoholic Intoxication, Chronic
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Linkage studies of alcoholism have implicated several chromosome regions, leading to the successful identification of susceptibility genes, including ADH4 and GABRA2 on chromosome 4.
|
24692236 |
2014 |
|
Alcoholic Intoxication, Chronic
|
0.500 |
Biomarker
|
disease |
PSYGENET |
A logistic regression analysis confirmed the association between ADH4 variants and alcohol dependence when sex, age, years of education, marital status and the allele genotype, haplotype and diplotype data of the six haplotype tag SNP were considered.
|
22044940 |
2012 |
|
Alcoholic Intoxication, Chronic
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
A logistic regression analysis confirmed the association between ADH4 variants and alcohol dependence when sex, age, years of education, marital status and the allele genotype, haplotype and diplotype data of the six haplotype tag SNP were considered.
|
22044940 |
2012 |
|
Alcoholic Intoxication, Chronic
|
0.500 |
Biomarker
|
disease |
PSYGENET |
This study confirms the significant relationship of ADH4 variants with AD and related phenotypes.
|
20626721 |
2011 |
|
Alcoholic Intoxication, Chronic
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
These results suggest that variants in the ADH1B and ADH4 genes may be protective against the development of some symptoms associated with alcohol dependence.
|
21635275 |
2011 |
|
Alcoholic Intoxication, Chronic
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The ADH4 SNP rs3762894 was associated with AD in Plains Indians.
|
21083667 |
2011 |
|
Alcoholic Intoxication, Chronic
|
0.500 |
Biomarker
|
disease |
PSYGENET |
These results suggest that variants in the ADH1B and ADH4 genes may be protective against the development of some symptoms associated with alcohol dependence.
|
21635275 |
2011 |
|
Alcoholic Intoxication, Chronic
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
This study confirms the significant relationship of ADH4 variants with AD and related phenotypes.
|
20626721 |
2011 |
|
Alcoholic Intoxication, Chronic
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Seven single nucleotide polymorphisms (SNPs) spanning the ADH4 gene were genotyped in 365 healthy controls (317 EAs and 48 AAs) and 561 subjects (400 EAs and 161 AAs) affected with alcohol dependence and/or drug dependence (436 with alcohol dependence; 356 with drug dependence).
|
16237392 |
2006 |
|
Alcoholic Intoxication, Chronic
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Haplotype tag SNPs were selected for the block in the ADH4 gene that provided evidence of association and subsequently used in association analysis; the haplotype was significantly associated with alcoholism (P=0.01) There was weaker evidence that variations in ADH1A and ADH1B might also play a role in modifying risk.
|
16571603 |
2006 |
|
Alcoholic Intoxication, Chronic
|
0.500 |
Biomarker
|
disease |
BEFREE |
These preliminary results suggest that ADH4 may play a role in the etiology of alcohol dependence.
|
15863808 |
2005 |
|
Alcoholic Intoxication, Chronic
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Transmission disequilibrium test, haplotype-based haplotype relative risk and genotype-based haplotype relative risk analyses all confirmed the association of the ADH4 markers with alcohol dependence and drug dependence.
|
16220108 |
2005 |
|
Alcoholic Intoxication, Chronic
|
0.500 |
Biomarker
|
disease |
BEFREE |
ADH(2), ADH(3), and CYP(450)2E1 Pst-I and Dra-I genetic variations are not related to alcoholism or susceptibility to alcoholic liver disease in our male population.ALDH(2) locus is monomorphic.
|
15519646 |
2004 |
|
Alcoholic Intoxication, Chronic
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The significant association between alcohol dehydrogenase (ADH)-2 genotype and alcohol-dependence risk, demonstrated in both Asian and non-Asian populations, suggests a link between the metabolism of alcohol (ethanol) and individual differences in susceptibility to dependence.
|
11584143 |
2001 |
|
Alcoholic Intoxication, Chronic
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The frequencies of the alleles ADH(2)2 and ADH(3)1, coding for the high-Vmax beta 2- and gamma 1-ADH respectively, and of the mutant ALDH(2)2 in the Oriental subjects with alcoholism or alcoholic cirrhosis are significantly lower than those in healthy controls.
|
8974324 |
1994 |