Fibrosis, Liver
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
α7KO mice fed an AD showed significant upregulation of the Col1a1 gene encoding alpha-1 type I collagen, which is involved in liver fibrosis, and the Ccl2 gene encoding C-C motif chemokine ligand 2, a pro-inflammatory chemokine; α7KO mice fed an MCD had significant upregulation of the Col1a1 gene and the Tnf gene, an inflammatory cytokine.
|
30369082 |
2019 |
Fibrosis, Liver
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Here, the relationship between SM α-actin and type 1 collagen expression (COL1A1), a major extracellular matrix protein important in liver fibrosis, is investigated with the results demonstrating that knockout of SM α-actin leads to reduced liver fibrosis and COL1 expression.
|
31476284 |
2019 |
Fibrosis, Liver
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
COL1A1 can precisely control sTβRII expression to inhibit excessive bioactive TGF-β level and thus inhibit hepatic fibrosis but without inducing autoimmune responses.
|
29934723 |
2018 |
Fibrosis, Liver
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
It also effectively inhibited the expression of two representative collagen proteins (COL1A1 and α-SMA) on both the mRNA and protein levels and showed a high safety profile in vivo, indicating its great promise as an anti-liver fibrosis agent.
|
29976890 |
2018 |
Fibrosis, Liver
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The mRNA expression levels of markers of liver fibrosis [alpha-smooth muscle actin (α-SMA) and collagen 1A1 (Col1A1)] were analyzed by quantitative reverse transcription-polymerase chain reaction (RT-PCR).
|
30522100 |
2018 |
Fibrosis, Liver
|
0.400 |
Biomarker
|
disease |
BEFREE |
Finally, we experimentally confirmed a functional regulatory module containing 5 miRNAs (miR-130b-3p, miR-148a-3p, miR-345-5p, miR-378a-3p, and miR-422a) and 6 genes (COL6A1, COL6A2, COL6A3, PIK3R3, COL1A1, CCND2) associated with liver fibrosis.
|
28919164 |
2017 |
Fibrosis, Liver
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Compared with CCl<sub>4</sub> injection alone, CCl<sub>4</sub> plus LPS injection exaggerated liver fibrosis in mice, as demonstrated by increased Col1a1 (collagen, type I, α 1), Acta2, Tgfb and Timp1 mRNA expression, ACTA2/α-SMA and COL1A1 protein expression, and Sirius Red staining area, which could be attenuated by injection of an autophagy inhibitor.
|
29160747 |
2017 |
Fibrosis, Liver
|
0.400 |
Biomarker
|
disease |
BEFREE |
There was additionally a negative correlation between serum lincRNA-p21 level and the markers of liver fibrosis including α-SMA and Col1A1.
|
28107589 |
2017 |
Fibrosis, Liver
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In vitro analysis using LX2 HSC cells indicated that AT‑II can augment TGF‑β1 and collagen type I α1 mRNA expression via periostin expression, suggesting that the interaction between AT‑II and periostin may serve a role in liver fibrosis development.
|
28849131 |
2017 |
Fibrosis, Liver
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Infusion of Ang-(1-7) alleviated BDL-induced liver fibrosis and inhibited the expression of Col1A1 and the activation of NLRP3 inflammasome in hepatocytes.
|
27445100 |
2016 |
Fibrosis, Liver
|
0.400 |
Biomarker
|
disease |
CTD_human |
Gene Expression Patterns Associated With Histopathology in Toxic Liver Fibrosis.
|
26396155 |
2016 |
Fibrosis, Liver
|
0.400 |
Biomarker
|
disease |
CTD_human |
Ascorbic acid suppresses endotoxemia and NF-κB signaling cascade in alcoholic liver fibrosis in guinea pigs: a mechanistic approach.
|
24239723 |
2014 |
Fibrosis, Liver
|
0.400 |
Biomarker
|
disease |
CTD_human |
Precision-cut liver slices as a model for the early onset of liver fibrosis to test antifibrotic drugs.
|
24321339 |
2014 |
Fibrosis, Liver
|
0.400 |
Biomarker
|
disease |
CTD_human |
Cannabinoid receptor type I modulates alcohol-induced liver fibrosis.
|
21863215 |
2011 |