Disease: Folic Acid Deficiency ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0016412
Disease: Folic Acid Deficiency
Folic Acid Deficiency 		0.010 Biomarker disease BEFREE Under folate deficiency, ALDH2 knockdown cells exhibited a 37% lower ratio of [<sup>14</sup>C]-formate to [<sup>3</sup>H]-hypoxanthine (<i>P</i> < 0.001) compared with wild-type HepG2 cells, indicating decreased use of exogenous formate, or increased endogenous formate synthesis, for de novo purine biosynthesis.<b>Conclusions:</b> In HepG2 cells, ADH5 is a source of formate for de novo purine biosynthesis, especially during folate deficiency when folate-dependent formate production is limited. 28228507 2017