cervical cancer
|
0.100 |
Biomarker
|
disease |
BEFREE |
Human Leukocyte Antigen (HLA) Class II -DRB1 and -DQB1 Alleles and the Association with Cervical Cancer in HIV/HPV Co-Infected Women in South Africa.
|
31258717 |
2019 |
cervical cancer
|
0.100 |
Biomarker
|
disease |
BEFREE |
HLA-B*15 showed a negative association with HPV-16-positive CaCx (0.1, 0.01), whereas DRB1*04 exhibited protection to both HPV-16-positive CaCx and persistent HPV-16 infection (0.3, 0.0001 and 0.1, 0.0002, respectively).
|
31800372 |
2019 |
cervical cancer
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Further, protective associations were evidenced for alleles B*35 and DRB1*10 and haplotypes A*11-B*35 and DRB1*10-DQB1*0501 with cervical cancer in South India.
|
27268619 |
2016 |
cervical cancer
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Human leukocyte antigen class II DRB1*1302 allele protects against cervical cancer: At which step of multistage carcinogenesis?
|
26235935 |
2015 |
cervical cancer
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Variation in LD between the classic HLA loci, rs9272143 and rs67841474 between populations may explain the different associations of HLA-B*07 and DRB1*1501-DQB1*0602 with cervical cancer between studies.
|
24520070 |
2014 |
cervical cancer
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Among the 25 specific alleles, six (DRB1*0301, *0403,*0404, *0803, *1312 and *1502) were associated with an increased risk cervical cancer in all studies.
|
24551099 |
2014 |
cervical cancer
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Haplotype analysis highlighted the significant association of HLA- DRB1*07:01-DQB1*02:02 and HLA DRB1*10:01-DQB1*05:01 with cervical cancer, while HLA-DRB1*14:04-DQB1*05:03 and DRB1*15:01-DQB1*06:01 conferred decreased risk for cervical cancer.
|
25673541 |
2014 |
cervical cancer
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We also confirmed previously reported associations of B*0702 and DRB1*1501-DQB1*0602 with susceptibility to and DRB1*1301-DQA1*0103-DQB1*0603 with protection against cervical cancer.
|
23482656 |
2013 |
cervical cancer
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Consistent associations across other studies in women with CC and infected by HPV16 were observed for HLA-DRB1*15 (OR, 3.9; 95% CI, 1.6-10.2) and the haplotype DRB1*15 DQB1*0602 (OR, 4.1; 95% CI, 1.4-12.7) compared with control women.
|
19820376 |
2009 |
cervical cancer
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The DRB1*13 allele/DRB1*13-DQB1*06 haplotype was strongly protective against risk to HPV infection (p(c) < 0.002) as well as cervical cancer (p(c) 0.01).
|
19272325 |
2009 |
cervical cancer
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In a similar fashion, the occurrence of DRB1 *13-DQB1 *06 (OR, 0.17; 95% CI, 0.04-0.80) haplotype was significantly lower in the study patients compared with the controls and may confer a decreased risk of CC among Han race population in the Guangdong Province of China.
|
19027490 |
2008 |
cervical cancer
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results indicate that HLA-DPB1*1301 may confer susceptibility to cervical cancer, and the haplotypes DRB1*150101-DQB1*0602 and DRB1*070101-DQB1*0201 may contribute to the resistance to the development of cervical cancer among Chinese women.
|
17349874 |
2007 |
cervical cancer
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
It was found that there was no significant association between DRB1-DQB1 haplotype and HPV16 prototype-positive cervical cancers.
|
17311339 |
2007 |
cervical cancer
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The strongest class II effects are coming from the DQB1 and DRB1 loci, but the DPB1 locus also contributes to the susceptibility to cervical cancer.
|
15238505 |
2004 |
cervical cancer
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We have examined the association of variation at the DRB1 and DQB1 loci with HPV16 infection and risk of development of cervical cancer by analysis of 440 cases diagnosed with cervical cancer in situ and 476 age-matched controls in a retrospective case-control study.
|
11519043 |
2001 |
cervical cancer
|
0.100 |
Biomarker
|
disease |
BEFREE |
In previous studies, the HLA class II haplotype HLA DRB1*0401-DQB1*0301 was shown to correlate with susceptibility to HPV infection, CIN and cervical cancer while DRB1*0101-DQB1*0501 indicated protection.
|
11562779 |
2001 |
cervical cancer
|
0.100 |
Biomarker
|
disease |
BEFREE |
Observations from this study confirm earlier findings of a negative association between DRB1*13 and cervical cancer and suggest that specific DRB1-DQB1 haplotype combinations, rather than individual DQB1*03 alleles, increase the risk for cervical cancer.
|
11588129 |
2001 |
cervical cancer
|
0.100 |
Biomarker
|
disease |
BEFREE |
In contrast, DRB1*1501 alone and in combination with DQB1*0602 was not significantly elevated in cancers overall, but did show some excess in HPV16-positive cancers (2P = 0.05), associated with HPV16-positive cervical cancers.
|
10755413 |
2000 |