Degenerative polyarthritis
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
The latter SNP was subsequently found to be associated with hip OA whereas COMP expression appeared responsive to the OA pathophysiology in cartilage.
|
25057126 |
2014 |
Degenerative polyarthritis
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Inhibition of ADAMTSs markedly increased the production of COL2A1, ACAN and COMP in chondrocytes isolated from the early stage of OA.
|
26162802 |
2015 |
Degenerative polyarthritis
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
In this study, we found that combined detection of serum CS846 and COMP levels can be used for diagnosis and monitoring of OA progression.
|
30208927 |
2018 |
Degenerative polyarthritis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The results indicate that COMP is the disease susceptibility gene and the c.2152C>T mutation in exon 18 could cause early-onset OA phenotypes in this kindred, which is compatible with a previous report that this mutation also causes a mild form of multiple epiphyseal dysplasia (MED).
|
21834907 |
2011 |
Degenerative polyarthritis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Cartilage oligomeric matrix protein is involved in human limb development and in the pathogenesis of osteoarthritis.
|
16542502 |
2006 |
Degenerative polyarthritis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Our results indicate that genetic polymorphisms affecting knee OA vary between populations (Japanese versus Caucasian) and sexes and indicate a role for ASPN, COMP, FRZB, and COL2A1 in Caucasians.
|
17195216 |
2007 |
Degenerative polyarthritis
|
0.500 |
Biomarker
|
disease |
BEFREE |
In multivariate analysis, COMP (OR 1.24, 95% CI 1.06 to 1.46), resistin (OR 1.26, 95% CI 1.07 to 1.48), MCP-1 (OR 1.10, 95% CI 0.07 to 1.48) and NGF (OR<0.001, 95% CI <0.001 to 0.25) were found to be independently associated with PsA versus OA.
|
30910989 |
2019 |
Degenerative polyarthritis
|
0.500 |
Biomarker
|
disease |
BEFREE |
COMP is a well-accepted biomarker for osteoarthritis but increased COMP levels do not necessarily correlate with inflammation.
|
25111190 |
2015 |
Degenerative polyarthritis
|
0.500 |
GeneticVariation
|
disease |
LHGDN |
An association between COMP and OA has been shown, yet the precise factors governing serum levels of COMP remain unclear.
|
16802351 |
2006 |
Degenerative polyarthritis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Both neuropeptides decreased ADAMTS-4, -5, -7 and -12 expressions, aggrecanase activity, glycosaminoglycans (GAG), and cartilage oligomeric matrix protein (COMP) degradation after stimulation with fibronectin fragments (Fn-fs) in OA-SF.
|
26818776 |
2016 |
Degenerative polyarthritis
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Synovium and cartilage from patients with osteoarthritis or rheumatoid arthritis were analyzed for expression of cartilage oligomeric matrix protein.
|
10376735 |
1999 |
Degenerative polyarthritis
|
0.500 |
Biomarker
|
disease |
BEFREE |
This complex between lubricin and the cartilage protein COMP can be identified in the SF of patients with arthritis conditions including osteoarthritis (OA) and rheumatoid arthritis (RA).
|
28373131 |
2017 |
Degenerative polyarthritis
|
0.500 |
Biomarker
|
disease |
BEFREE |
An association between COMP and OA has been shown, yet the precise factors governing serum levels of COMP remain unclear.
|
16802351 |
2006 |
Degenerative polyarthritis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Three neopeptides belonging to Clusterin and one from Cartilage Oligomeric Matrix Protein showed a disease-dependent decrease specifically in hip OA, whereas two from Prolargin (PRELP) and one from Cartilage Intermediate Layer Protein 1 were significantly increased in samples from knee OA.
|
31352363 |
2019 |
Degenerative polyarthritis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Mean lnHA, lnCOMP, and lnhs-CRP were significantly higher in the hand OA group, compared with the non-hand OA or control group.
|
18291686 |
2008 |
Degenerative polyarthritis
|
0.500 |
Biomarker
|
disease |
BEFREE |
The elevated levels of matrix metalloproteinases‑13 and two bio‑markers for the diagnosis and progression of OA, such as the cartilage oligomeric matrix protein and C‑telopeptide of type II collagen, were markedly ameliorated by MF administration in MIA‑induced OA rats.
|
29067461 |
2017 |
Degenerative polyarthritis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Disulfide bound complexes of lubricin and cartilage oligomeric matrix protein (COMP) have recently been identified in arthritic synovial fluid suggesting they may be lost from the cartilage surface in osteoarthritis and inflammatory arthritis.
|
29030641 |
2017 |
Degenerative polyarthritis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Additionally, biomarkers of OA such as MMP-9, COMP, and CTX-II decreased in the monosodium iodoacetate (MIA)-induced rat OA model by MFSCC treatment.
|
31575035 |
2019 |
Degenerative polyarthritis
|
0.500 |
AlteredExpression
|
disease |
LHGDN |
Cartilage oligomeric matrix protein is involved in human limb development and in the pathogenesis of osteoarthritis.
|
16542502 |
2006 |
Degenerative polyarthritis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Our results demonstrate that serum concentrations of PIIANP, HA, COMP, and C2C have substantial heritable components, and using these biomarkers, several genetic loci potentially contributing to the genetic diversity of OA were identified.
|
20187133 |
2010 |
Degenerative polyarthritis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Our results could contribute to the development of disease-modifying OA drugs targeting ADAMTS-7 and -12 for the prevention of extracellular matrix components degradation like COMP.
|
30903650 |
2019 |
Degenerative polyarthritis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We have previously shown that the mutations p.R116W and p.C299S, associated with MED and SEMD, respectively, cause retention of matrilin-3 within the endoplasmic reticulum of primary chondrocytes, while the mutation associated with osteoarthritis, p.T298M, does not hinder secretion.
|
20077500 |
2010 |
Degenerative polyarthritis
|
0.500 |
Biomarker
|
disease |
BEFREE |
We found strong evidence for the presence of IgG isotype autoantibodies against the cartilage extracellular matrix proteins TSP-4, COMP and CLEC3A in OA.
|
30001809 |
2018 |
Degenerative polyarthritis
|
0.500 |
Biomarker
|
disease |
BEFREE |
In addition, the elevated levels of matrix metalloproteinases-13 and two biomarkers for diagnosis and progression of OA, such as cartilage oligomeric matrix protein and C-telopeptide of type II collagen, were markedly ameliorated by SF administration.
|
28507472 |
2017 |
Degenerative polyarthritis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Therefore, we examined immunohistochemically the extracellular distribution of collagen II and the main perifibrillar adapter proteins-collagen IX, decorin, cartilage oligomeric matrix protein (COMP), and matrilin-3-in human samples of healthy (n=4) and OA (n=42) knee joint cartilage.
|
28846474 |
2017 |