Degenerative polyarthritis
|
0.500 |
Biomarker
|
disease |
BEFREE |
In multivariate analysis, COMP (OR 1.24, 95% CI 1.06 to 1.46), resistin (OR 1.26, 95% CI 1.07 to 1.48), MCP-1 (OR 1.10, 95% CI 0.07 to 1.48) and NGF (OR<0.001, 95% CI <0.001 to 0.25) were found to be independently associated with PsA versus OA.
|
30910989 |
2019 |
Degenerative polyarthritis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Three neopeptides belonging to Clusterin and one from Cartilage Oligomeric Matrix Protein showed a disease-dependent decrease specifically in hip OA, whereas two from Prolargin (PRELP) and one from Cartilage Intermediate Layer Protein 1 were significantly increased in samples from knee OA.
|
31352363 |
2019 |
Degenerative polyarthritis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Additionally, biomarkers of OA such as MMP-9, COMP, and CTX-II decreased in the monosodium iodoacetate (MIA)-induced rat OA model by MFSCC treatment.
|
31575035 |
2019 |
Degenerative polyarthritis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Our results could contribute to the development of disease-modifying OA drugs targeting ADAMTS-7 and -12 for the prevention of extracellular matrix components degradation like COMP.
|
30903650 |
2019 |
Degenerative polyarthritis
|
0.500 |
Biomarker
|
disease |
BEFREE |
The production of COMP, CTX-II and osteopontin (OPN) were also inhibited in MIA-induced OA rats.
|
31342791 |
2019 |
Degenerative polyarthritis
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
IHC demonstrated that those with osteoarthritis, had greater expression of COMP in the prostate samples (mean 23.9% vs 5.84%, p<0.05) but not of Ki-67, CD31, or PSMA.
|
31413818 |
2019 |
Degenerative polyarthritis
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
In this study, we found that combined detection of serum CS846 and COMP levels can be used for diagnosis and monitoring of OA progression.
|
30208927 |
2018 |
Degenerative polyarthritis
|
0.500 |
Biomarker
|
disease |
BEFREE |
We found strong evidence for the presence of IgG isotype autoantibodies against the cartilage extracellular matrix proteins TSP-4, COMP and CLEC3A in OA.
|
30001809 |
2018 |
Degenerative polyarthritis
|
0.500 |
Biomarker
|
disease |
BEFREE |
The most exciting clinical application is the use of COMP as a biomarker for idiopathic pulmonary fibrosis and cartilage degeneration associated osteoarthritis and rheumatoid and, as a prognostic marker for joint injury.
|
29530484 |
2018 |
Degenerative polyarthritis
|
0.500 |
Biomarker
|
disease |
BEFREE |
This complex between lubricin and the cartilage protein COMP can be identified in the SF of patients with arthritis conditions including osteoarthritis (OA) and rheumatoid arthritis (RA).
|
28373131 |
2017 |
Degenerative polyarthritis
|
0.500 |
Biomarker
|
disease |
BEFREE |
The elevated levels of matrix metalloproteinases‑13 and two bio‑markers for the diagnosis and progression of OA, such as the cartilage oligomeric matrix protein and C‑telopeptide of type II collagen, were markedly ameliorated by MF administration in MIA‑induced OA rats.
|
29067461 |
2017 |
Degenerative polyarthritis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Disulfide bound complexes of lubricin and cartilage oligomeric matrix protein (COMP) have recently been identified in arthritic synovial fluid suggesting they may be lost from the cartilage surface in osteoarthritis and inflammatory arthritis.
|
29030641 |
2017 |
Degenerative polyarthritis
|
0.500 |
Biomarker
|
disease |
BEFREE |
In addition, the elevated levels of matrix metalloproteinases-13 and two biomarkers for diagnosis and progression of OA, such as cartilage oligomeric matrix protein and C-telopeptide of type II collagen, were markedly ameliorated by SF administration.
|
28507472 |
2017 |
Degenerative polyarthritis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Therefore, we examined immunohistochemically the extracellular distribution of collagen II and the main perifibrillar adapter proteins-collagen IX, decorin, cartilage oligomeric matrix protein (COMP), and matrilin-3-in human samples of healthy (n=4) and OA (n=42) knee joint cartilage.
|
28846474 |
2017 |
Degenerative polyarthritis
|
0.500 |
Biomarker
|
disease |
BEFREE |
For the COMP neoepitope the AT group showed the highest median value, followed by the ReA group, the OA group, and the RA group.
|
28473207 |
2017 |
Degenerative polyarthritis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We discovered two rare signals that strongly associate with osteoarthritis total hip replacement: a missense variant, c.1141G>C (p.Asp369His), in the COMP gene (allelic frequency = 0.026%, P = 4.0 × 10<sup>-12</sup>, odds ratio (OR) = 16.7) and a frameshift mutation, rs532464664 (p.Val330Glyfs*106), in the CHADL gene that associates through a recessive mode of inheritance (homozygote frequency = 0.15%, P = 4.5 × 10<sup>-18</sup>, OR = 7.71).
|
28319091 |
2017 |
Degenerative polyarthritis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Both neuropeptides decreased ADAMTS-4, -5, -7 and -12 expressions, aggrecanase activity, glycosaminoglycans (GAG), and cartilage oligomeric matrix protein (COMP) degradation after stimulation with fibronectin fragments (Fn-fs) in OA-SF.
|
26818776 |
2016 |
Degenerative polyarthritis
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Inhibition of ADAMTSs markedly increased the production of COL2A1, ACAN and COMP in chondrocytes isolated from the early stage of OA.
|
26162802 |
2015 |
Degenerative polyarthritis
|
0.500 |
Biomarker
|
disease |
BEFREE |
COMP is a well-accepted biomarker for osteoarthritis but increased COMP levels do not necessarily correlate with inflammation.
|
25111190 |
2015 |
Degenerative polyarthritis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Overexpression of ADAMTS-7 gene promotes the breakdown of cartilage oligomeric matrix protein (COMP) matrix and accelerates the progression of both surgically induced osteoarthritis and collagen-induced arthritis.
|
26696755 |
2015 |
Degenerative polyarthritis
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
The latter SNP was subsequently found to be associated with hip OA whereas COMP expression appeared responsive to the OA pathophysiology in cartilage.
|
25057126 |
2014 |
Degenerative polyarthritis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The results indicate that COMP is the disease susceptibility gene and the c.2152C>T mutation in exon 18 could cause early-onset OA phenotypes in this kindred, which is compatible with a previous report that this mutation also causes a mild form of multiple epiphyseal dysplasia (MED).
|
21834907 |
2011 |
Degenerative polyarthritis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Our results demonstrate that serum concentrations of PIIANP, HA, COMP, and C2C have substantial heritable components, and using these biomarkers, several genetic loci potentially contributing to the genetic diversity of OA were identified.
|
20187133 |
2010 |
Degenerative polyarthritis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We have previously shown that the mutations p.R116W and p.C299S, associated with MED and SEMD, respectively, cause retention of matrilin-3 within the endoplasmic reticulum of primary chondrocytes, while the mutation associated with osteoarthritis, p.T298M, does not hinder secretion.
|
20077500 |
2010 |
Degenerative polyarthritis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Mean lnHA, lnCOMP, and lnhs-CRP were significantly higher in the hand OA group, compared with the non-hand OA or control group.
|
18291686 |
2008 |