COMT, catechol-O-methyltransferase, 1312

N. diseases: 622; N. variants: 47
Disease: Headache ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0018681
Disease: Headache
Headache 		0.040 GeneticVariation phenotype BEFREE Intriguingly, in migraine patients, the COMT rs4680 polymorphism influenced headache response to triptans in the opposite direction. 23773341 2013
CUI: C0018681
Disease: Headache
Headache 		0.040 GeneticVariation phenotype BEFREE The literature on inverted-U effects in the PFC suggests that catechol-O-methyltransferase (COMT) Met versus Val polymorphisms may predict excess dopaminergic effects, including headache and introversion in Met/Met subjects, but therapeutic effects in Val/Val subjects, while dopamine transporter polymorphisms may predict motor side effects. 22689336 2013
CUI: C0018681
Disease: Headache
Headache 		0.040 AlteredExpression phenotype BEFREE Hence, in neuropathic and cancer pains, COMT activity is meaningless but in some chronic musculoskeletal pain conditions and migraine or headache low COMT activity appears to increase incidence and symptoms. 21095465 2010
CUI: C0018681
Disease: Headache
Headache 		0.040 GeneticVariation phenotype BEFREE The association between headache and Val158Met polymorphism in the catechol-O-methyltransferase gene: the HUNT Study. 16688411 2006