COMT, catechol-O-methyltransferase, 1312

N. diseases: 622; N. variants: 47
Disease: Low Back Pain ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0024031
Disease: Low Back Pain
Low Back Pain 		0.030 Biomarker phenotype BEFREE In this study, we assessed the correlation between 8 genetic polymorphisms (VDR, COL11, MMP1, MMP9, IL-1α, IL-1RN, OPRM1, COMT) and pain recovery in patients with low back pain (LBP) and lumbar radicular pain (LRP). 28471875 2017
CUI: C0024031
Disease: Low Back Pain
Low Back Pain 		0.030 GeneticVariation phenotype BEFREE We conclude that the functional COMT Val158Met SNP contributes to long lasting low back pain, sciatica and disability after lumbar disc herniation. 22337560 2012
CUI: C0024031
Disease: Low Back Pain
Low Back Pain 		0.030 GeneticVariation phenotype BEFREE This study examines the association between COMT polymorphisms and 7-11 year change in Oswestry Disability Index (ODI) and Visual Analog Score (VAS) for LBP as clinical outcome variables in patients treated with surgical instrumented lumbar fusion or cognitive intervention and exercise. 22612913 2012