COMT, catechol-O-methyltransferase, 1312

N. diseases: 622; N. variants: 47
Disease: Metabolic Syndrome X ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.030 Biomarker disease BEFREE This study aimed at determining the prevalence and influence of COMT on MetS among a population undergoing long-term clozapine treatment. 24448899 2014
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.030 PosttranslationalModification disease BEFREE This study examined the correlation between COMT promoter methylation and metabolic syndrome in schizophrenia patients receiving atypical antipsychotic (AAP) therapy. 22391769 2013
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.030 GeneticVariation disease BEFREE From this work, genetic variation within both the methylenetetrahydrofolate reductase (MTHFR) gene and the catechol-O-methyltransferase (COMT) gene has been associated with an increased risk of metabolic syndrome in schizophrenia patients treated with AAPs. 23341251 2013