|
Blood Protein Measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genomic atlas of the human plasma proteome.
|
29875488 |
2018 |
|
Blood Protein Measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Co-regulatory networks of human serum proteins link genetics to disease.
|
30072576 |
2018 |
|
Malignant Neoplasms
|
0.050 |
AlteredExpression
|
group |
BEFREE |
Furthermore, immunotherapy clinical trials comprising over 600 patients across 6 cancer types revealed elevated levels of the LRRC15+ CAF signature correlated with poor response to anti-PD-L1 therapy.
|
31699795 |
2020 |
|
Primary malignant neoplasm
|
0.050 |
AlteredExpression
|
group |
BEFREE |
Furthermore, immunotherapy clinical trials comprising over 600 patients across 6 cancer types revealed elevated levels of the LRRC15+ CAF signature correlated with poor response to anti-PD-L1 therapy.
|
31699795 |
2020 |
|
Malignant Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
In summary, these findings validate LRRC15 as a novel therapeutic target in multiple solid tumor indications and support the ongoing clinical development of the LRRC15-targeted ADC ABBV-085.<b>Significance:</b> These findings identify LRRC15 as a new marker of cancer-associated fibroblasts and cancers of mesenchymal origin and provide preclinical evidence for the efficacy of an antibody-drug conjugate targeting the tumor stroma.<i>Cancer Res; 78(14); 4059-72.©2018 AACR</i>.
|
29764866 |
2018 |
|
Malignant Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
The tumor antigen 15-leucine-rich repeat containing membrane protein (LRRC15) is a transmembrane protein demonstrated to play important roles in cancer.
|
29523191 |
2018 |
|
Primary malignant neoplasm
|
0.050 |
Biomarker
|
group |
BEFREE |
In summary, these findings validate LRRC15 as a novel therapeutic target in multiple solid tumor indications and support the ongoing clinical development of the LRRC15-targeted ADC ABBV-085.<b>Significance:</b> These findings identify LRRC15 as a new marker of cancer-associated fibroblasts and cancers of mesenchymal origin and provide preclinical evidence for the efficacy of an antibody-drug conjugate targeting the tumor stroma.<i>Cancer Res; 78(14); 4059-72.©2018 AACR</i>.
|
29764866 |
2018 |
|
Primary malignant neoplasm
|
0.050 |
Biomarker
|
group |
BEFREE |
The tumor antigen 15-leucine-rich repeat containing membrane protein (LRRC15) is a transmembrane protein demonstrated to play important roles in cancer.
|
29523191 |
2018 |
|
Malignant Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
Tumor antigen LRRC15 impedes adenoviral infection: implications for virus-based cancer therapy.
|
18385238 |
2008 |
|
Primary malignant neoplasm
|
0.050 |
Biomarker
|
group |
BEFREE |
Tumor antigen LRRC15 impedes adenoviral infection: implications for virus-based cancer therapy.
|
18385238 |
2008 |
|
Malignant Neoplasms
|
0.050 |
AlteredExpression
|
group |
BEFREE |
Here, we used cDNA subtractive hybridization to identify an endogenous gene, LRRC15, which is specifically up-regulated after inducible expression of EWS-WT1(+KTS) in cancer cell lines, and is expressed within primary DSRCT cells.
|
12923058 |
2003 |
|
Primary malignant neoplasm
|
0.050 |
AlteredExpression
|
group |
BEFREE |
Here, we used cDNA subtractive hybridization to identify an endogenous gene, LRRC15, which is specifically up-regulated after inducible expression of EWS-WT1(+KTS) in cancer cell lines, and is expressed within primary DSRCT cells.
|
12923058 |
2003 |
|
Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
These LRRC15+ CAFs surround tumor islets and are absent from normal pancreatic tissue.
|
31699795 |
2020 |
|
Neoplasm Metastasis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Immunohistochemistry and mouse xenograft studies were performed to confirm the role of LRRC15 in promoting metastasis.
|
31204077 |
2019 |
|
Tumor Progression
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Increased expression of LRRC15 in BMets was confirmed by immunohistochemistry and knockdown of LRRC15 significantly inhibited tumor progression in mice.
|
31204077 |
2019 |
|
Degenerative polyarthritis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Myristoylated alanine rich protein kinase C substrate (<i>MARCKS</i>), epiregulin (<i>EREG</i>), leucine rich repeat containing 15 (<i>LRRC15</i>), and phosphodiesterase 3A (<i>PDE3A</i>) expression patterns were similar among related OA cartilage, subchondral bone and synovial tissue arrays in Gene Expression Omnibus database.
|
30544699 |
2018 |
|
Solid Neoplasm
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
LRRC15 was expressed on stromal fibroblasts in many solid tumors (e.g., breast, head and neck, lung, pancreatic) as well as directly on a subset of cancer cells of mesenchymal origin (e.g., sarcoma, melanoma, glioblastoma).
|
29764866 |
2018 |
|
Sarcoma
|
0.010 |
AlteredExpression
|
group |
BEFREE |
LRRC15 was expressed on stromal fibroblasts in many solid tumors (e.g., breast, head and neck, lung, pancreatic) as well as directly on a subset of cancer cells of mesenchymal origin (e.g., sarcoma, melanoma, glioblastoma).
|
29764866 |
2018 |
|
Malignant neoplasm of soft tissue
|
0.010 |
AlteredExpression
|
group |
BEFREE |
LRRC15 was expressed on stromal fibroblasts in many solid tumors (e.g., breast, head and neck, lung, pancreatic) as well as directly on a subset of cancer cells of mesenchymal origin (e.g., sarcoma, melanoma, glioblastoma).
|
29764866 |
2018 |
|
Fetal Growth Retardation
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
Placental development, which can affect the development of multiple fetal organs and induce IUGR, is a hypermethylated cluster consisting of four significantly changed genes, including syncytin b (Synb), Lrrc15, Met, and Tex19.1.
|
28604758 |
2017 |
|
Adenoviral infections
|
0.010 |
Biomarker
|
group |
BEFREE |
LRRC15, however, does not impede p53 function per se but impedes adenoviral infection.
|
18385238 |
2008 |
|
Infection
|
0.010 |
Biomarker
|
group |
LHGDN |
Tumor antigen LRRC15 impedes adenoviral infection: implications for virus-based cancer therapy.
|
18385238 |
2008 |
|
Alzheimer's Disease
|
0.010 |
Biomarker
|
disease |
LHGDN |
Lib, transcriptionally induced in senile plaque-associated astrocytes, promotes glial migration through extracellular matrix.
|
16098915 |
2005 |