|
Pneumonia
|
0.010 |
Biomarker
|
disease |
BEFREE |
The aim of this study was to investigate the contribution of IL-17RE/IL-17C to pulmonary inflammation in a mouse model of acute <i>Streptococcus pneumoniae</i> pneumonia.
|
31481409 |
2019 |
|
Infectious Lung Disorder
|
0.010 |
Biomarker
|
group |
BEFREE |
Numbers of neutrophils were significantly reduced in lungs of mice deficient for IL-17C 24 h after infection with <i>S. pneumoniae</i> These data indicate that the IL-17C/IL-17RE axis promotes the recruitment of neutrophils without affecting the recovery of alveolar macrophages in the acute phase of <i>S. pneumoniae</i> lung infection.
|
31481409 |
2019 |
|
Pneumonitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
The aim of this study was to investigate the contribution of IL-17RE/IL-17C to pulmonary inflammation in a mouse model of acute <i>Streptococcus pneumoniae</i> pneumonia.
|
31481409 |
2019 |
|
Autoimmune Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Targeting the IL-17C/IL-17RE pathway may present an intriguing therapeutic strategy for T<sub>H</sub>17-induced autoimmune disorders.
|
29483158 |
2018 |
|
Dermatitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
In support of that, IL-17C was demonstrated to contribute to development of T cell-dependent imiquimod-induced psoriatic dermatitis and T cell-independent dextran sodium sulfate-induced acute colitis using mice deficient in IL-17C and/or IL-17RE, which is a component of the receptor for IL-17C.
|
30356086 |
2018 |
|
Kidney Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Our findings indicate that IL-17C promotes T<sub>H</sub>17 cell responses and immune-mediated kidney disease <i>via</i> IL-17RE expressed on CD4<sup>+</sup> T<sub>H</sub>17 cells.
|
29483158 |
2018 |
|
Idiopathic crescentic glomerulonephritis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Finally, IL-17RE was highly expressed by CD4<sup>+</sup> T<sub>H</sub>17 cells, and loss of this expression prevented the T<sub>H</sub>17 responses and subsequent tissue injury in crescentic GN.
|
29483158 |
2018 |
|
Acute colitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
In support of that, IL-17C was demonstrated to contribute to development of T cell-dependent imiquimod-induced psoriatic dermatitis and T cell-independent dextran sodium sulfate-induced acute colitis using mice deficient in IL-17C and/or IL-17RE, which is a component of the receptor for IL-17C.
|
30356086 |
2018 |
|
Hepatitis
|
0.010 |
Biomarker
|
group |
BEFREE |
In this study, we demonstrated the functional importance of the IL-17C/IL-17RE axis in Con A-induced hepatitis.
|
27956525 |
2017 |
|
Hepatitis A
|
0.010 |
Biomarker
|
disease |
BEFREE |
In this study, we demonstrated the functional importance of the IL-17C/IL-17RE axis in Con A-induced hepatitis.
|
27956525 |
2017 |
|
Autoimmune Chronic Hepatitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
To our knowledge, our findings thus for the first time defined the indispensable role of IL-17C/IL-17RE in autoimmune hepatitis; this axis may serve as a novel drug target for the treatment of this disease.
|
27956525 |
2017 |
|
Autoimmune hepatitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
To our knowledge, our findings thus for the first time defined the indispensable role of IL-17C/IL-17RE in autoimmune hepatitis; this axis may serve as a novel drug target for the treatment of this disease.
|
27956525 |
2017 |
|
Celiac Disease
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Children with untreated CD had diminished levels of IL-17RE, IL-23R, RORc, STAT6, CCL22, NFATC2, IL-18, CD4, CD247, and matrix metalloproteinase (MMP)9 but had elevated levels of MMP3, IL-17, interferon-γ (IFN-γ) and CD8A, compared to references.
|
24325470 |
2014 |
|
Anemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, IL17RE rs708567 GA and hHbS rs334 AT individuals were associated with protection from uncomplicated malaria and anaemia respectively in this study.
|
24312262 |
2013 |
|
Malaria
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, IL17RE rs708567 GA and hHbS rs334 AT individuals were associated with protection from uncomplicated malaria and anaemia respectively in this study.
|
24312262 |
2013 |
|
Sickle Cell Trait
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, IL17RE rs708567 GA and hHbS rs334 AT individuals were associated with protection from uncomplicated malaria and anaemia respectively in this study.
|
24312262 |
2013 |