|
Cardiovascular Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
This review will provide an overview of current knowledge about the physiological roles of Uro-II, UCN and AM in the cardiovascular system and their implications in cardiovascular diseases.
|
30481494 |
2019 |
|
Cardiovascular Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Elevated plasma levels of the vasodilating hormone adrenomedullin (ADM) predict cardiovascular disease and have been associated with hypertension and obesity.
|
30540625 |
2019 |
|
Cardiovascular Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
The AM-RAMP system may thus have therapeutic potential for the treatment of cardiovascular diseases.
|
29689347 |
2019 |
|
Cardiovascular Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Adrenomedullin is a prognostic biomarker in several cardiovascular diseases and was recently shown to associate with hemodynamic instability in patients with septic shock.
|
28050899 |
2017 |
|
Cardiovascular Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Single nucleotide polymorphisms of the ADM gene are associated with blood pressure variability, and elevated levels of plasma midregional proadrenomedullin (MR-pro-ADM) are associated with cardiovascular diseases.
|
25053723 |
2014 |
|
Cardiovascular Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Elevated plasma adrenomedullin (ADM) levels are associated with cardiovascular diseases.
|
23088295 |
2013 |
|
Cardiovascular Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Adrenomedullin (AM) is a peptide involved both in the pathogenesis of cardiovascular diseases and in circulatory homeostasis.
|
18097473 |
2008 |
|
Cardiovascular Diseases
|
0.100 |
AlteredExpression
|
group |
LHGDN |
Specifically, we find that certain conditions, such as pregnancy, cardiovascular disease, and sepsis, are associated with robust and dynamic changes in the expression of AM and AM receptor proteins, which together represent an elegant mechanism for altering the physiological responsiveness or function of AM.
|
17053041 |
2007 |
|
Cardiovascular Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
These findings suggest that AM plays a role in the development of or response to cardiovascular disease.
|
16616959 |
2006 |
|
Cardiovascular Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
These findings have raised the possibility that decreased expression of adrenomedullin by tumor necrosis factor-alpha may be related to the increased risk of hypertension and other cardiovascular diseases in obese subjects.
|
15808915 |
2005 |
|
Cardiovascular Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
In particular, CGRP has potent activity in the cerebral circulation, which is possibly relevant to the pathology of migraine, whilst vascular sources of AM contribute to dysfunction in cardiovascular disease.
|
15269340 |
2004 |
|
Cardiovascular Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Variations of human adrenomedullin gene and its relation to cardiovascular diseases.
|
12630823 |
2003 |
|
Cardiovascular Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Therefore, in this review we will focus on the structure of AM and its gene, distribution, receptor, and the physiological and pathological roles of AM in cardiovascular disease.
|
11921351 |
2002 |
|
Cardiovascular Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The actions of adrenomedullin and the activation of this peptide in cardiovascular disease suggest it may have an important pathophysiologic role in heart failure.
|
11305974 |
2001 |
|
Cardiovascular Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
These findings provide new insights into the role of AM in renovascular hypertension and may have significance in therapeutic applications in cardiovascular diseases.
|
11352835 |
2001 |
|
Cardiovascular Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Adrenomedullin (AM), a potent vasodilator peptide, has natriuretic effects, and its plasma concentration is elevated in cardiovascular diseases.
|
11254908 |
2001 |
|
Cardiovascular Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Biological and clinical roles of adrenomedullin in circulation control and cardiovascular diseases.
|
10386225 |
1999 |