ADM, adrenomedullin, 133

N. diseases: 26; N. variants: 0
Source: CURATED ×
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0243026
Disease: Sepsis
Sepsis 		0.600 Biomarker disease CTD_human Role of cyclooxygenase in ventricular effects of adrenomedullin: is adrenomedullin a double-edged sword in sepsis? 14766677 2004
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia 		0.510 Biomarker phenotype CTD_human By activating specific receptors (likely AM2) and the PI3K/Akt/GSK3beta signaling pathway, AM could play a significant role in long-lasting heat hypersensitivity and inflammatory heat hyperalgesia. 17043245 2006
CUI: C0017658
Disease: Glomerulonephritis
Glomerulonephritis 		0.510 Biomarker disease CTD_human Renal AM level and its mRNA expression were increased in rats with GN compared with controls (Peptide Cortex: +69%; Medulla: +82%; mRNA Cortex: +25%). 15680492 2005
CUI: C0017658
Disease: Glomerulonephritis
Glomerulonephritis 		0.510 Biomarker disease CTD_human These results suggest that mycophenolate mofetil suppresses the renal damage in rats with autoimmune glomerulonephritis and renal adrenomedullin may participate in the pathophysiology of autoimmune glomerulonephritis. 15063164 2004
CUI: C0023893
Disease: Liver Cirrhosis, Experimental
Liver Cirrhosis, Experimental 		0.500 Biomarker disease CTD_human Local regulator adrenomedullin contributes to the circulatory disturbance in cirrhotic rats. 16610064 2006
CUI: C0023893
Disease: Liver Cirrhosis, Experimental
Liver Cirrhosis, Experimental 		0.500 Biomarker disease CTD_human Adrenomedullin contributes to vascular hyporeactivity in cirrhotic rats with ascites via a release of nitric oxide. 15370692 2004
CUI: C0036690
Disease: Septicemia
Septicemia 		0.400 Biomarker disease CTD_human Role of cyclooxygenase in ventricular effects of adrenomedullin: is adrenomedullin a double-edged sword in sepsis? 14766677 2004
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.330 Biomarker disease PSYGENET These findings suggest the possible role of ADM and SEPX1 as biomarkers of schizophrenia. 18081029 2008
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.330 Biomarker disease PSYGENET Our data support that ADM may be associated with the pathophysiology of schizophrenia, although the cause of the association needs further study. 15194870 2004
CUI: C2936719
Disease: Mechanical Allodynia
Mechanical Allodynia 		0.320 Biomarker phenotype CTD_human A role for adrenomedullin as a pain-related peptide in the rat. 17043245 2006
CUI: C0030193
Disease: Pain
Pain 		0.310 Biomarker phenotype CTD_human Taken together, our results demonstrate that AM acts as a pain-inducing peptide in the dorsal horn. 17043245 2006
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.300 Biomarker disease PSYGENET A whole genome expression analysis of peripheral blood mononuclear cells yielded 12 protein-coding genes (ADM, APBB3, CD160, CFD, CITED2, CTSZ, IER5, NFKBIZ, NR4A2, NUCKS1, SERTAD1, TNF) that were differentially expressed between 29 unmedicated depressed patients with a mood disorder (8 bipolar disorder, 21 major depressive disorder) and 24 healthy controls (HCs). 23064081 2013
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.300 Biomarker disease PSYGENET Cross-disorder genomewide analysis of schizophrenia, bipolar disorder, and depression. 20713499 2010
CUI: C0234230
Disease: Pain, Burning
Pain, Burning 		0.300 Biomarker phenotype CTD_human A role for adrenomedullin as a pain-related peptide in the rat. 17043245 2006
CUI: C0234238
Disease: Ache
Ache 		0.300 Biomarker phenotype CTD_human A role for adrenomedullin as a pain-related peptide in the rat. 17043245 2006
CUI: C0234254
Disease: Radiating pain
Radiating pain 		0.300 Biomarker phenotype CTD_human A role for adrenomedullin as a pain-related peptide in the rat. 17043245 2006
CUI: C0458247
Disease: Allodynia
Allodynia 		0.300 Biomarker phenotype CTD_human A role for adrenomedullin as a pain-related peptide in the rat. 17043245 2006
CUI: C0458257
Disease: Pain, Splitting
Pain, Splitting 		0.300 Biomarker phenotype CTD_human A role for adrenomedullin as a pain-related peptide in the rat. 17043245 2006
CUI: C0458259
Disease: Pain, Crushing
Pain, Crushing 		0.300 Biomarker phenotype CTD_human A role for adrenomedullin as a pain-related peptide in the rat. 17043245 2006
CUI: C0751211
Disease: Hyperalgesia, Primary
Hyperalgesia, Primary 		0.300 Biomarker phenotype CTD_human A role for adrenomedullin as a pain-related peptide in the rat. 17043245 2006
CUI: C0751212
Disease: Hyperalgesia, Secondary
Hyperalgesia, Secondary 		0.300 Biomarker phenotype CTD_human A role for adrenomedullin as a pain-related peptide in the rat. 17043245 2006
CUI: C0751213
Disease: Tactile Allodynia
Tactile Allodynia 		0.300 Biomarker phenotype CTD_human A role for adrenomedullin as a pain-related peptide in the rat. 17043245 2006
CUI: C0751214
Disease: Hyperalgesia, Thermal
Hyperalgesia, Thermal 		0.300 Biomarker phenotype CTD_human A role for adrenomedullin as a pain-related peptide in the rat. 17043245 2006
CUI: C0751407
Disease: Pain, Migratory
Pain, Migratory 		0.300 Biomarker phenotype CTD_human A role for adrenomedullin as a pain-related peptide in the rat. 17043245 2006
CUI: C0751408
Disease: Suffering, Physical
Suffering, Physical 		0.300 Biomarker phenotype CTD_human A role for adrenomedullin as a pain-related peptide in the rat. 17043245 2006