|
Schizophrenia
|
0.180 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study of schizophrenia in Ashkenazi Jews.
|
26198764 |
2015 |
|
Schizophrenia
|
0.180 |
GeneticVariation
|
disease |
BEFREE |
A previous genome-wide association study (GWAS) of schizophrenia conducted in the Swedish population demonstrated a significant association of rs6878284, which is located in the SLCO6A1 gene, with schizophrenia.
|
26861727 |
2016 |
|
Schizophrenia
|
0.180 |
GeneticVariation
|
disease |
BEFREE |
Thus, here we studied Glutathione S-transferase (GST) A1 polymorphism and diffusion tensor imaging-mean diffusivity (MD) data on deep grey matter brain structures in 56 patients with Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revised (DSM-IV-TR) schizophrenia.
|
22959778 |
2013 |
|
Schizophrenia
|
0.180 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association analysis identifies 13 new risk loci for schizophrenia.
|
23974872 |
2013 |
|
Schizophrenia
|
0.180 |
GeneticVariation
|
disease |
BEFREE |
These results suggest that GST gene polymorphisms do not confer increased susceptibility to TD in patients with schizophrenia but TD severity might be related with GST-P1 variants.
|
19051221 |
2009 |
|
Schizophrenia
|
0.180 |
Biomarker
|
disease |
BEFREE |
In order to address some of these shortcomings, we have analyzed a broader set of oxidative stress biomarkers in our exploratory study, including urinary 8-iso-prostaglandin F2α (8-iso-PGF2α), 8-OH-2-deoyxguanosine (8-OH-2-dG), and blood levels of malondialdehyde (MDA), superoxide dismutase (SOD) and glutathione S-transferase (GST) in acutely ill drug-naïve first episode patients with schizophrenia (n = 22), major depression (n = 18), and controls (n = 43).
|
27913877 |
2018 |
|
Schizophrenia
|
0.180 |
GeneticVariation
|
disease |
BEFREE |
The association between polymorphisms of glutathione-related enzyme (GST) genes and the risk of schizophrenia has been investigated in many published studies.
|
26295386 |
2015 |
|
Schizophrenia
|
0.180 |
Biomarker
|
disease |
BEFREE |
Therefore, GST genes may exemplify molecular connectors between ATDILI and SCZ.
|
26046920 |
2015 |
|
Schizophrenia
|
0.180 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, among the few relatively common CNVs observed in patients and controls, the combined analysis of gene copy number genotypes at two glutathione S-transferase (GST) genes, GSTM1 (glutathione S-transferase mu 1) (1p13.3) and GSTT2 (glutathione S-transferase theta 2) (22q11.23), showed a statistically significant association of non-null genotypes at both loci with an additive effect for increased vulnerability to schizophrenia (odds ratio of 1.92; P=0.0008).
|
19528963 |
2010 |
|
Schizophrenia
|
0.180 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association analysis identifies 13 new risk loci for schizophrenia.
|
23974872 |
2013 |
|
Schizophrenia
|
0.180 |
GeneticVariation
|
disease |
BEFREE |
We found that the combination of the absence of GSTM1 gene with the of the GSTM1 gene with the polymorphism GSTA1*B/*B, and the presence of the GSTT1 gene, represents a risk factor for schizophrenia, indicating that the combination of different GST polymorphisms has a role in the predisposition to schizophrenia, probably affecting the capacity of the cell to detoxify the oxidized metabolites of catecholamines.
|
21093063 |
2011 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The assay made it possible to distinguish individuals with zero, one, and two copies and thereby to investigate whether the GST genes influenced susceptibility to asthma in a dose-dependent manner.
|
15300848 |
2004 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
There are limited studies on the role of interaction between exposure to ambient air pollution and glutathione-S-transferase (GST) P1 on the risk of asthma/wheezing among children, which provided suggestive, but inconclusive results.
|
23357926 |
2013 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Several studies have shown that the GSTP1 geneis involved in the pathogenesis of asthma and a gene-gene interaction may occur within the GST gene superfamily.
|
17643058 |
2007 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Because ozone produces oxidative stress, increased airway TNF, and inflammation, the associations of the -308 TNF polymorphism with asthma may vary by ozone exposure and variants of oxidant defense genes glutathione-S-transferase (GST) M1 and GSTP1.
|
16456144 |
2006 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The results show a potential association between the GST genes and asthma.
|
20374258 |
2010 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
It has been suggested that the genetically determined deficiency of glutathione S transferase (GST) enzymes involved in the detoxification of environmental tobacco smoke (ETS) components may contribute to the development of asthma.
|
15223862 |
2004 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We studied T cell responses to four glutathione S transferase (GST)-fused mite antigens prepared in our laboratory using peripheral blood lymphocytes from mite-sensitive patients with bronchial asthma.
|
9158099 |
1997 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The aim of the present study was to investigate the role of polymorphisms in the GSTT1, GSTM1 and GSTP1 genes and asthma susceptibility in Egyptian children, and to analyze their effect on GST activity and lung function.
|
22326267 |
2012 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Glutathione S-transferase (GST) M1 may play a role in asthma and wheezing occurrence among those exposed to tobacco smoke, as it functions in pathways involved in asthma pathogenesis such as xenobiotic metabolism and antioxidant defenses.
|
12186820 |
2002 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
People with a polymorphism at the GSTP 1 locus, which codes for GST, one of a family of pulmonary antioxidants, have higher rates of asthma.
|
16340710 |
2005 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results suggest that the GST-T1 null genotype and increased oxidative stress may play a role in the asthma pathogenesis in children.
|
20134034 |
2009 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To investigate the association of GST gene polymorphisms and its enzyme activity with the risk of asthma in Hong Kong Chinese adults.
|
17651144 |
2007 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
BHR was assessed at baseline by methacholine challenge and defined as a fall of > or =20% in forced expiratory volume in 1 s. Independent effects of GST polymorphisms and BHR on new onset of asthma after 11 years of follow-up were estimated by multiple logistic regression analysis, adjusting for relevant baseline measures.
|
18057098 |
2008 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Multiple logistic regressions were performed to assess the association between GST polymorphisms and incense burning frequency on asthma and wheeze, after adjusting for potential confounders.
|
21109554 |
2011 |