Obesity
|
0.370 |
Biomarker
|
disease |
BEFREE |
Two strong positional candidates, the human peroxisome proliferator-activated receptor gamma coactivator 1 (PPARGC1) and cholecystokinin A receptor (CCKAR) with major roles in the development of obesity, are located in this region.
|
14740316 |
2004 |
Obesity
|
0.370 |
AlteredExpression
|
disease |
BEFREE |
We examined the expression of PGC-1, PPAR gamma, insulin receptor substrate-1 (IRS-1), glucose transporter isoform-4 (GLUT-4), and mitochondrial uncoupling protein-1 (UCP-1) in adipose tissue and skeletal muscle from non-obese, non-diabetic insulin-resistant, and insulin-sensitive individuals.
|
12565902 |
2003 |
Obesity
|
0.370 |
Biomarker
|
disease |
BEFREE |
These studies suggest functional differences of PPARGC1 haplotypes in human energy metabolism and support a role of PPARGC1 in obesity.
|
11916956 |
2002 |
Mammary Neoplasms
|
0.320 |
AlteredExpression
|
group |
BEFREE |
We initially assessed PGC-1β expression in complementary DNA (cDNA) from breast tumor of patients bearing luminal A, luminal B, and HER2-overexpressed and triple negative tumors.
|
26602383 |
2016 |
Mammary Neoplasms
|
0.320 |
Biomarker
|
group |
CTD_human |
Transcriptional control of the ERBB2 amplicon by ERRalpha and PGC-1beta promotes mammary gland tumorigenesis.
|
20961995 |
2010 |
Mammary Neoplasms
|
0.320 |
Biomarker
|
group |
LHGDN |
Associations of genetic variants in the estrogen receptor coactivators PPARGC1A, PPARGC1B and EP300 with familial breast cancer.
|
16704985 |
2006 |
Mammary Neoplasms, Human
|
0.300 |
Biomarker
|
disease |
CTD_human |
Transcriptional control of the ERBB2 amplicon by ERRalpha and PGC-1beta promotes mammary gland tumorigenesis.
|
20961995 |
2010 |
Mammary Carcinoma, Human
|
0.300 |
Biomarker
|
disease |
CTD_human |
Transcriptional control of the ERBB2 amplicon by ERRalpha and PGC-1beta promotes mammary gland tumorigenesis.
|
20961995 |
2010 |
Hyperlipidemia
|
0.300 |
Biomarker
|
disease |
CTD_human |
Hepatic PGC-1beta overexpression induces combined hyperlipidemia and modulates the response to PPARalpha activation.
|
17932310 |
2007 |
Lipidemias
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Hepatic PGC-1beta overexpression induces combined hyperlipidemia and modulates the response to PPARalpha activation.
|
17932310 |
2007 |
Sepsis
|
0.200 |
Biomarker
|
disease |
RGD |
Sepsis and glucocorticoids downregulate the expression of the nuclear cofactor PGC-1beta in skeletal muscle.
|
20647557 |
2010 |
Basal cell carcinoma
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Combined analysis of keratinocyte cancers identifies novel genome-wide loci.
|
31174203 |
2019 |
Basal Cell Neoplasm
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Combined analysis of keratinocyte cancers identifies novel genome-wide loci.
|
31174203 |
2019 |
Basal Cell Cancer
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Combined analysis of keratinocyte cancers identifies novel genome-wide loci.
|
31174203 |
2019 |
Melanosis
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study in Japanese females identifies fifteen novel skin-related trait associations.
|
29895819 |
2018 |
Cutaneous Melanoma
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways.
|
30429480 |
2018 |
Malignant melanoma of skin of upper limb
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways.
|
30429480 |
2018 |
Malignant melanoma of skin of lower limb
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways.
|
30429480 |
2018 |
Suntan
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genome-wide association study in 176,678 Europeans reveals genetic loci for tanning response to sun exposure.
|
29739929 |
2018 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Haplotype comparison analysis indicated that CTTCGGG and CTCTGGG haplotypes with the order of PPARG rs1801282 C>G, PPARG rs3856806 C>T, PPARGC1A rs8192678 C>T, PPARGC1A rs2970847 C>T, PPARGC1A rs3736265 G>A, PPARGC1B rs7732671 G>C and PPARGC1B rs17572019 G>A polymorphisms in gene position significantly increased the risk of T2DM.
|
28418876 |
2017 |
Vitiligo
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association studies of autoimmune vitiligo identify 23 new risk loci and highlight key pathways and regulatory variants.
|
27723757 |
2016 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.100 |
Biomarker
|
disease |
BEFREE |
Furthermore, our research pinpoints the role of several new T2D-associated genes (such as Srebf1 and Ppargc1) in the human population.
|
25758573 |
2014 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.100 |
Biomarker
|
disease |
BEFREE |
The effect of exercise on epigenetic modifications of PGC1: The impact on type 2 diabetes.
|
24703492 |
2014 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Genetic variation in the peroxisome proliferator-activated receptor (PPAR) and peroxisome proliferator-activated receptor gamma co-activator 1 (PGC1) gene families and type 2 diabetes.
|
24359475 |
2014 |
Low density lipoprotein cholesterol measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASDB |
Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.
|
23063622 |
2012 |