PPARGC1B, PPARG coactivator 1 beta, 133522

N. diseases: 102; N. variants: 16
Disease: Viral myocarditis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0276138
Disease: Viral myocarditis
Viral myocarditis 		0.010 AlteredExpression disease BEFREE In conclusion, we provide evidence that acute VM is associated with extensive cardiac metabolic remodelling and our data support a mechanism whereby cytokines secreted primarily from infiltrating leukocytes activate NF-κB signalling in cardiomyocytes thereby inhibiting the transcriptional activity of the PGC-1 network and consequently modulating myocardial energy metabolism. 29730342 2018