PPARGC1B, PPARG coactivator 1 beta, 133522

N. diseases: 102; N. variants: 16
Disease: Left ventricular diastolic dysfunction ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1273070
Disease: Left ventricular diastolic dysfunction
Left ventricular diastolic dysfunction 		0.010 AlteredExpression disease BEFREE Increased adipose cell size, hepatic fat deposition, malondialdehyde (MDA) content and NEFA level, down-regulation of IRS1, IRS2, PI3K, Akt, p-Akt, Glut2 and PGC1ɑ expression concomitant with up-regulation of mTOR, GSK3β, TNF-ɑ, FOXO1, p-mTOR and p-p70S6K expression in the liver tissue, as well as hypertension and left ventricular diastolic dysfunction were observed in HFC-fed minipigs. 30686655 2019