Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Therefore, patients with overexpressed IMP3 had a poorer prognosis (P<0.01); COX regression analysis revealed that the overexpression of IMP3, the tumor grade, tumor size and metastasis of GEP-NEN were each associated with the clinical outcomes.
|
28454409 |
2017 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Expression of beta-galactosidase co-localized with that of Factor VIII in tumor sections.
|
12464651 |
2002 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The expression of factor VIII, an angiogenesis marker, in tumor sections was increased in tumors derived from PC3-15LOS cells and decreased in those from PC3-15LOAS cells compared with tumors from parental or Zeo cells.
|
11698337 |
2001 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We clarified the role of tumor-associated macrophages (TAMs) and their downstream factor milk-fat globule-epidermal growth factor-VIII (MFG-E8) in the regulation of CSC activities.
|
21746895 |
2011 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Tumor microvessel density (MDV), the essential factor of microenvironment and proliferating cell nucleus antigen (PCNA), indexes as tumor cell proliferating in its microenvironment are also analyzed by immunohistochemical methods using antibodies against endothelial protein factor VIII related antigen (F8RA) and antibody PC-10.
|
9894772 |
1998 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
[(Prop-2-ynyl)-2-acetoxybenzoate]dicobalthexacarbonyl (Co-ASS), an organometallic derivative of the irreversible cyclooxygenase-1/2 (COX-1/2) inhibitor acetylsalicylic acid (ASS), demonstrated high growth-inhibitory potential against various tumor cell lines and inhibition of both COX isoenzymes.
|
29492489 |
2018 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The mass was severely compressing the brainstem as well as the cranial nerves V, VI, VII, and VIII while IV was encased by the tumor.
|
31162584 |
2020 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Increased microvessel formation coincident with high expression of Factor VIII and increased numbers of reticulocytes confirmed the angiogenic property of AKT/HCT-116 tumors.
|
24000138 |
2014 |
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Among the 79 patients who underwent laparoscopic hepatectomy, intercostal trocars were used in 14 patients for resection of tumors located in segment VII (4 nodules) or VIII (10 nodules).
|
27444836 |
2017 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Here, we examined the expression of p-STAT3 in the tumor tissues from 90 patients with newly diagnosed supratentorial GBM via immunohistochemical technique and evaluated the influences of its expression on progression-free survival (PFS) and overall survival (OS) using the Kaplan-Meier curve and COX proportional hazards regression model.
|
24652192 |
2014 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In the survival analysis, COX regression showed that T stage, plasma miRNA 106b and tumor miRNA 93 were significant risk factors for overall survival [HR: 0.400 (0.205-0.780); <i>P </i>= 0.007; HR: 0.371 (0.142-0.969), <i>P </i>= 0.043; 0.295 (0.134-0.650), <i>P </i>= 0.002].
|
31384175 |
2019 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The data on the prognostic importance of COX expression in these tumours is inconsistent and conflicting.
|
24950702 |
2014 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Although the biological function of CA-RPs is unknown, overexpression of CA-RP VIII has been reported in certain tumor types.
|
15942747 |
2005 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Although the diagnosis and treatment of eighth cranial nerve (VIII CN) schwannoma (acoustic neuroma) has improved over the years, no factors capable of predicting tumor growth have been identified as yet.
|
28430338 |
2017 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In an independent validation, patients with reduced COX protein expression prior to treatment exhibited favourable clinical outcomes to chemotherapy, whereas tumours with unchanged COX expression were chemoresistant.
|
23592244 |
2013 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Immunoperoxidase levels in the tumor were positive for factor VIII and CD31 and negative for S100, protein Melan-A, CD34, synaptophysin, chromogranin, desmin, muscle specific actin, ETFA (EMA), KRT20 (CK20), CDX2, TTF1, LNPEP (PLAP), inhibin, ?-fetoprotein, CD30, hepatocyte paraffin, and aberrant expression of cytokeratin 7 and pankeratin.
|
28441375 |
2017 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We wanted to assess the expression of CARPs VIII and XI in these tumors and study their association to different clinicopathological features and tumor-associated CAs II, IX and XII.
|
29792187 |
2018 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
COX regression multivariate analysis identified post auto-SCT treatment failure before 12 months (hazard ratio (HR) 3.37, CI 1.7-6.6, P value < 0.001), presence of B symptoms (HR 2.55, CI 1.4-4.6, P value 0.002), stages III-IV (HR 2.7, CI 1.5-4.9, P value 0.001), albumin < 4 g/dl (HR 1.76, CI 1.1-2.9, P value 0.027) and tumor > 5 cm (HR 1.1.9, CI 1.13-3.25, P value 0.015) as significant risk factors; P value < 0.001.
|
29484455 |
2018 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Immunohistochemistry analysis indicated that the expression of VEGF and number of capillaries (factor VIII assay) were approximately 3-fold greater in SF188/V+ tumors compared to SF188/V- tumors.
|
9872603 |
1998 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Patients with nonsense/frameshift mutations have a younger age of diagnosis and a higher prevalence/proportion of meningiomas (p = 0.002, p = 0.014), spinal tumours (p = 0.004, p = 0.004) and non-VIII cranial nerve tumours (p = 0.006, p = 0.003).
|
19968670 |
2010 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Many in vitro and in vivo studies on human and animal models have explained the mechanisms of the chemopreventive effect of COX inhibitors such as: induction of apoptosis, inhibition of neoplasia, angiogenesis suppression, induction of cell cycle inhibition and inhibition of the expression of peroxisome proliferator-activated receptors.
|
30897717 |
2019 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
To cast light on the role(s) of COX enzymes in the development and progression of colorectal cancers and to determine the incidence of COX-2 overexpression, the expression levels of COX-1 and COX-2 proteins using Western blot analysis in tumor tissues and adjacent normal tissues obtained from 44 Thai patients with colorectal cancer.
|
15075004 |
2004 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Multicolor immunohistofluorescence staining confirmed the COX-expression profiles in organotypic 3D cultures and the COX-2 dominance in OSCC tumors.
|
19278989 |
2009 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
These results, coupled with the inhibition of the cell proliferation by electroporation of melanoma cells with cPLA(2) or COX-2 antibodies, demonstrate that a possible correlation between PLA(2)-COX expression and tumor cell proliferation in the melanocytic system does exist.
|
18722548 |
2008 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The cyclooxygenase/prostaglandin (COX/PG) signaling pathway is of central importance in inflammation and neoplasia.
|
23624019 |
2013 |