|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Microvessels assessed by immunostaining endothelial cells for factor VIII were counted on a 400x field in the most active areas of neovascularization within the tumor.
|
8757190 |
1996 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Immunohistochemically, one neoplasm showed focal positivity for S-100 protein but was uniformly negative for cytokeratin (AE1/AE3), factor VIII, and CD31.
|
9149016 |
1997 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Tumor microvessel density (MDV), the essential factor of microenvironment and proliferating cell nucleus antigen (PCNA), indexes as tumor cell proliferating in its microenvironment are also analyzed by immunohistochemical methods using antibodies against endothelial protein factor VIII related antigen (F8RA) and antibody PC-10.
|
9894772 |
1998 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Immunohistochemistry analysis indicated that the expression of VEGF and number of capillaries (factor VIII assay) were approximately 3-fold greater in SF188/V+ tumors compared to SF188/V- tumors.
|
9872603 |
1998 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
No differences were observed between the vascular endothelial cells expressing PECAM-1 and factor VIII in serial sections of control and mIFN-gamma-treated tumors.
|
11029496 |
2000 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Histological and immunohistochemical studies of AdVmIL-12-treated tumors showed extensive inhibition of neovascularization and a marked decrease in factor VIII-stained endothelial cells.
|
11103813 |
2000 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The expression of factor VIII, an angiogenesis marker, in tumor sections was increased in tumors derived from PC3-15LOS cells and decreased in those from PC3-15LOAS cells compared with tumors from parental or Zeo cells.
|
11698337 |
2001 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Mice fed various COX blocking agents also showed a decline in tumor size.
|
11313976 |
2001 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Immunocytochemical staining for factor VIII detected a 3.5-fold increase in microvessel density of the primary tumors produced by PSV-VEGF-2 cells when compared with that of the primary tumors developed from the control pSV-R37 cells.
|
11389060 |
2001 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Moreover, maspin-positive cases showed a significant decrease in tumor vessels positively stained with anti-factor VIII-related antigen antibody.
|
11485832 |
2001 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Expression of beta-galactosidase co-localized with that of Factor VIII in tumor sections.
|
12464651 |
2002 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Factor VIII expression was measured by immunohistochemistry in tumor samples.
|
12231546 |
2002 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
These results suggest an involvement of COX-2 in the control of tumor-dependent angiogenesis and growth in certain pancreatic cancers and provide the rational for inhibition of the COX pathway as an effective therapeutic approach for pancreatic tumors.
|
12533667 |
2003 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
To cast light on the role(s) of COX enzymes in the development and progression of colorectal cancers and to determine the incidence of COX-2 overexpression, the expression levels of COX-1 and COX-2 proteins using Western blot analysis in tumor tissues and adjacent normal tissues obtained from 44 Thai patients with colorectal cancer.
|
15075004 |
2004 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Genotype-phenotype correlations are well documented for overall NF2 disease severity but have not been definitively evaluated for specific types of non-VIII nerve tumors.
|
15190457 |
2004 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Although the biological function of CA-RPs is unknown, overexpression of CA-RP VIII has been reported in certain tumor types.
|
15942747 |
2005 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Transfection with stefin A showed a dramatic reduction of factor VIII staining in the tumors of xenograft mice.
|
16361563 |
2005 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Micro vessel density was analyzed in Factor VIII-stained tumor sections by the immunohistochemical SP method.
|
16830360 |
2006 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We assessed treatment efficacy by survival analysis or measuring growth, respectively.In the i.p. model, on day 120, three of eight animals treated with this novel triple therapy consisting of Ad.H/F, gemcitabine, and Ad.COX*MK were alive and tumor free.
|
16928822 |
2006 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
These results, coupled with the inhibition of the cell proliferation by electroporation of melanoma cells with cPLA(2) or COX-2 antibodies, demonstrate that a possible correlation between PLA(2)-COX expression and tumor cell proliferation in the melanocytic system does exist.
|
18722548 |
2008 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Immunohistochemical (IHC) staining for EGFR and factor VIII-related antigen was undertaken to detect the microvessel density and VEGF expression in tumor tissue in xenograft nude mice.
|
18803351 |
2008 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Multicolor immunohistofluorescence staining confirmed the COX-expression profiles in organotypic 3D cultures and the COX-2 dominance in OSCC tumors.
|
19278989 |
2009 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Finally, anti-CXCR2 Ab significantly reduced tumor volume (p < 0.05), Ki-67 proliferation index (p = 0.043) and Factor VIII(+) microvessel density (p = 0.004) in an orthotopic nude mouse PaCa model.
|
19431209 |
2009 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Patients with nonsense/frameshift mutations have a younger age of diagnosis and a higher prevalence/proportion of meningiomas (p = 0.002, p = 0.014), spinal tumours (p = 0.004, p = 0.004) and non-VIII cranial nerve tumours (p = 0.006, p = 0.003).
|
19968670 |
2010 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We clarified the role of tumor-associated macrophages (TAMs) and their downstream factor milk-fat globule-epidermal growth factor-VIII (MFG-E8) in the regulation of CSC activities.
|
21746895 |
2011 |