Blood Coagulation Disorders
|
0.100 |
Biomarker
|
group |
BEFREE |
Randomised and quasi-randomised controlled trials investigating the efficacy of DDAVP versus tranexamic acid or factor VIII or rFactor VII or fresh frozen plasma in preventing and treating congenital bleeding disorders during pregnancy were eligible.
|
30758840 |
2019 |
Blood Coagulation Disorders
|
0.100 |
Biomarker
|
group |
BEFREE |
Elevated fibrinogen, von Willebrand factor, and Factor VIII confer resistance to dilutional coagulopathy and activated protein C in normal pregnant women.
|
30916034 |
2019 |
Blood Coagulation Disorders
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Hemophilia A and B are rare inherited bleeding disorders resulting from deficiency of coagulation factors VIII and IX respectively.
|
30328141 |
2019 |
Blood Coagulation Disorders
|
0.100 |
Biomarker
|
group |
BEFREE |
Congenital hemophilia A, a relatively common and sometimes life-threatening bleeding disorder, is caused by inherited deficiency of clotting factor (F) VIII.
|
30612605 |
2019 |
Blood Coagulation Disorders
|
0.100 |
Biomarker
|
group |
BEFREE |
Individuals with the inherited bleeding disorder hemophilia have achieved tremendous advances in clinical outcomes through widespread implementation of prophylactic replacement with safe and efficacious factor VIII and IX.
|
29077262 |
2018 |
Blood Coagulation Disorders
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Hemophilia A (HA) is an X-linked bleeding disorder caused by heterogeneous mutations in the factor VIII gene ( F8).
|
28056528 |
2018 |
Blood Coagulation Disorders
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Hemophilia A and B are inherited bleeding disorders due to deficiencies of the clotting factors VIII and IX, respectively.
|
28550758 |
2017 |
Blood Coagulation Disorders
|
0.100 |
Biomarker
|
group |
BEFREE |
Phenotype 2 (factors V and VIII abnormalities) explained 17.0% and was associated with increased coagulopathy, blunt injury, and mortality.
|
27906868 |
2017 |
Blood Coagulation Disorders
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Deficiencies of blood coagulation factors VIII and IX (haemophilia A and haemophilia B) represent the most common inherited bleeding disorders with a wide range of causative mutations.
|
25255241 |
2015 |
Blood Coagulation Disorders
|
0.100 |
Biomarker
|
group |
BEFREE |
The immune response against therapeutic clotting factors VIII and IX (FVIII and FIX) is a major adverse event that can effectively thwart their effectiveness in correcting bleeding disorders.
|
24762281 |
2014 |
Blood Coagulation Disorders
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The intron 22 inversion of factor VIII gene (F8) causes 40-50 % of severe bleeding disorder of HA in all human populations.
|
24994666 |
2014 |
Blood Coagulation Disorders
|
0.100 |
Biomarker
|
group |
BEFREE |
Hemophilia A is a congenital, recessive, X-linked bleeding disorder that is managed with infusions of plasma-derived or recombinant factor (F) VIII.
|
24717090 |
2014 |
Blood Coagulation Disorders
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The type of factor VIII/IX mutation is a major determinant of the bleeding tendency as well as of the risk of inhibitor formation; thus, there is a biological plausibility behind the different clinical expression of these two forms of congenital hemophilia.
|
24014073 |
2013 |
Blood Coagulation Disorders
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Overexpression of factor VII ameliorates bleeding diathesis of factor VIII-deficient mice with inhibitors.
|
23566532 |
2013 |
Blood Coagulation Disorders
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Combined factor V and factor VIII deficiency (F5F8D) is a rare autosomal recessive coagulation disorder associated with plasma levels of coagulation factors V and VIII approximately 5% to 30% normal.
|
20460353 |
2011 |
Blood Coagulation Disorders
|
0.100 |
Biomarker
|
group |
BEFREE |
Seventy-nine patients had rare coagulation disorders including deficiency of factor VII (n = 26), factor X (n = 18), factor XIII (n = 9), factor I (n = 9), factor XI (n = 7), factor V (n = 4), combined factor VIII and factor V (n = 4), and combined factor X and factor VII (n = 2).
|
19710607 |
2009 |
Blood Coagulation Disorders
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Combined deficiency of factors V and VIII (F5F8D) is a bleeding disorder caused by mutations in LMAN1 or MCFD2.
|
18056485 |
2008 |
Blood Coagulation Disorders
|
0.100 |
Biomarker
|
group |
BEFREE |
Congenital deficiency of factor (F) VIII results in the inherited X-linked bleeding disorder hemophilia A.
|
16879218 |
2006 |
Blood Coagulation Disorders
|
0.100 |
Biomarker
|
group |
BEFREE |
Recent gene transfer trials for hemophilia A and B, bleeding disorders lacking either functional factor VIII or IX, respectively, have produced tantalizing results, suggesting that the potential to correct these bleeding disorders at a molecular level may be at hand.
|
12776156 |
2003 |
Blood Coagulation Disorders
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Hemophilia A is an X-linked severe bleeding disorder and is caused by mutations in the Factor VIII gene.
|
12884004 |
2003 |
Blood Coagulation Disorders
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Deficiencies of coagulation factors (other than factor VIII and factor IX) that cause a bleeding disorder are inherited as autosomal recessive traits and are generally rare, with prevalences in the general population varying between 1 : 500 000 and 1 : 2 000 000.
|
12010428 |
2002 |
Blood Coagulation Disorders
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Correction of the coagulation defect in hemophilia A mice through factor VIII expression in skin.
|
10779424 |
2000 |
Blood Coagulation Disorders
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Combined factor V-factor VIII deficiency (F5F8D) is a rare, autosomal recessive coagulation disorder in which the levels of both coagulation factors V and VIII are diminished.
|
10090934 |
1999 |
Blood Coagulation Disorders
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Combined factors V and VIII deficiency is an autosomal recessive bleeding disorder associated with plasma levels of coagulation factors V and VIII approximately 5% to 30% of normal.
|
10090935 |
1999 |
Blood Coagulation Disorders
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The structure explains, in part, mutations in the C2 region of factor VIII that lead to bleeding disorders in haemophilia A.
|
10586887 |
1999 |