|
Activated Protein C Resistance
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Its protective effect is mediated by reduced factor VIII levels and reduced activated protein C resistance.
|
30842582 |
2019 |
|
Activated Protein C Resistance
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The screening for thrombophilia included mutations of factor V Leiden (FVL), prothrombin (PTM) G20210A, methylene tetrahydrofolate reductase C677T-A1298C, the serum levels of antithrombin III, protein C, protein S, factor VIII and activated protein C resistance.
|
23358198 |
2013 |
|
Activated Protein C Resistance
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Activated protein C resistance has a stronger association with stroke than factor V Leiden and may be caused by other factors such as elevated factor VIII levels in the Asian Indian population apart from factor V Leiden itself.
|
19560187 |
2009 |
|
Activated Protein C Resistance
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Thrombophilia was suspected and the relative investigation revealed high levels of factor VIII procoagulant, which is frequent in hemodialysis patients, and resistance to activated protein C. Polymerase chain reaction detected that the patient was heterozygous for factor V Leiden, which is quite common in general population.
|
18387172 |
2008 |
|
Activated Protein C Resistance
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The factor VIII D1241E polymorphism is associated with decreased factor VIII activity and not with activated protein C resistance levels.
|
15735794 |
2005 |
|
Activated Protein C Resistance
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
All 11 cases had one or more familial thrombophilic coagulation disorder including one heterozygous for the G1691A factor V Leiden mutation, two with low free protein S, four with high factor VIII, three with resistance to activated protein C, three homozygous for the C677T methylenetetrahydrofolate reductase (MTHFR) mutation, two compound C677T-A1298C MTHFR heterozygotes, and three with hypofibrinolytic 4G4G homozygosity for the PAI-1 gene.
|
16015408 |
2005 |
|
Activated Protein C Resistance
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Comparing 23 RVO cases < or = age 55 and controls < or = age 55 (n = 44 for PCR, n = 40 for serologic measures), RAPC was present in 17% of cases vs 0% controls (p(f) = .026), high Factor VIII in 17% vs 0% (p(f) = .026), heterozygosity for the G1691A Factor V Leiden mutation in 13% vs 2% (p(f) = 0.11), and the 4G allele frequency of the PAI-1 gene 74% vs 39% (p = .0001).
|
16244763 |
2005 |
|
Activated Protein C Resistance
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Among the 124 FV Leiden negative subjects with a persistent APC resistance phenotype, 40 (32%) had a plasma factor VIII coagulant activity level above 150 IU/dl and eight (6.4%) were carriers of the G20210A prothrombin allele.
|
15257714 |
2004 |
|
Activated Protein C Resistance
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
After excluding subjects with FVL or elevated factor VIII levels, 4 subjects still had APC resistance.
|
12520697 |
2003 |
|
Activated Protein C Resistance
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
A new locus on chromosome 18 that influences normal variation in activated protein C resistance phenotype and factor VIII activity and its relation to thrombosis susceptibility.
|
12393556 |
2003 |
|
Activated Protein C Resistance
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Newly described abnormalities associated with thrombophilia include the syndrome of activated Protein C resistance (APCR), the prothrombin 20210A mutation, hyperhomocysteinemia, and elevated levels of coagulation factors VIII and XI.
|
12032428 |
2002 |
|
Activated Protein C Resistance
|
0.100 |
Biomarker
|
disease |
BEFREE |
Testing plasmas from normal volunteers who had received 1-deamino-8-D-arginine vasopressin (DDAVP) also assessed the effect of elevated factor VIII on APCR.
|
11414631 |
2001 |
|
Activated Protein C Resistance
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The relationship between APC resistance and factor V level was not observed in a factor VIII-independent model.
|
10739373 |
2000 |
|
Activated Protein C Resistance
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We adjusted for VIII:C levels, which appeared to affect our APC resistance test.
|
9949170 |
1999 |
|
Activated Protein C Resistance
|
0.100 |
Biomarker
|
disease |
BEFREE |
Mutation at either Arg336 or Arg562 in factor VIII is insufficient for complete resistance to activated protein C (APC)-mediated inactivation: implications for the APC resistance test.
|
9531040 |
1998 |
|
Activated Protein C Resistance
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Search for mutations in the genes for coagulation factors V and VIII with a possible predisposition to activated protein C resistance.
|
9134384 |
1997 |