Venous Thromboembolism
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Altered levels of factor (F)VIII, prothrombin, or antithrombin have been associated with an increased risk for venous thromboembolism (VTE).
|
30408635 |
2018 |
Venous Thromboembolism
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Hypothyroidism leads to a higher incidence of acquired von Willebrand's syndrome and with increasing levels of free thyroxine, levels of fibrinogen, factor VIII and von Willebrand factor, amongst others, increase gradually, to the extent that they may lead to symptomatic venous thromboembolism in patients with hyperthyroidism.
|
29573126 |
2018 |
Venous Thromboembolism
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Results The HR for VTE with lower eGFR was 1.13 (95% confidence interval [CI] 1.02-1.25), and VTE risk was attenuated by 23% (95% CI 5-100) by D-dimer, by 100% (95% CI 50-100) by factor VIII, and by 15% (95% CI 2-84) by C-reactive protein.
|
29984467 |
2018 |
Venous Thromboembolism
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
The goal of this study was to examine how plasma levels of factor V, VIII, XIIIa, von Willebrand factor antigen (vWF:Ag), fibrinogen, thrombomodulin evolve from the point of diagnosis of acute VTE to the end of standard treatment period.
|
28868636 |
2018 |
Venous Thromboembolism
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Factor VIII is an essential cofactor in the coagulation cascade and a strong risk factor for VTE in general.
|
30081388 |
2018 |
Venous Thromboembolism
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Plasma factor VIII levels were significantly higher in VTE patients than in healthy controls (251% vs. 99%, p<0.01).
|
23403259 |
2013 |
Venous Thromboembolism
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
The presence of genetic thrombophilic polymorphisms among patients with MM was superimposable to that of normal controls and was associated with a twofold increase in the relative risk of VTE. aAPCR and elevated factor VIII levels were frequent, albeit transient, alterations and were not associated with a significant increase in the risk of VTE.
|
20192986 |
2010 |
Venous Thromboembolism
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Increased levels of factor VIII (odds ratio [OR], 3.1; 95% confidence interval [CI], 1.6-6.0), von Willebrand factor (OR, 2.8; 95% CI, 1.4-5.4), non-O blood group (OR, 2.1; 95% CI, 1.3-3.4), and thrombophilia (OR, 3.4; 95% CI, 1.6-7.1) emerged as independent risk factors for venous thromboembolism.
|
19398413 |
2009 |
Venous Thromboembolism
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
A negative D-dimer result, non-elevated factor VIII level and non-elevated thrombin generation after discontinuation of anticoagulant treatment, female sex and distal location might be useful in determining a low risk of recurrence in patients with VTE.
|
19624456 |
2009 |
Venous Thromboembolism
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
The A1 and B alleles of the ABO blood system have been associated with high levels of both factor VIII and von Willebrand factor and with a predisposition to venous thromboembolism (VTE).
|
19786939 |
2009 |
Venous Thromboembolism
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Association of ADAMDEC1 haplotype with high factor VIII levels in venous thromboembolism.
|
18449420 |
2008 |
Venous Thromboembolism
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Low-density lipoprotein receptor-related protein 1 polymorphism 663 C > T affects clotting factor VIII activity and increases the risk of venous thromboembolism.
|
17155964 |
2007 |
Venous Thromboembolism
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
High factor VIII levels in venous thromboembolism show linkage to imprinted loci on chromosomes 5 and 11.
|
15353485 |
2005 |
Venous Thromboembolism
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
The ABO blood group genotype and factor VIII levels as independent risk factors for venous thromboembolism.
|
15735796 |
2005 |
Venous Thromboembolism
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Adjusted for age, sex, other concomitant thrombophilic disorders and exogenous risk factors, the odds ratio for venous thromboembolism were 2.7 (0.8-8.7) for high factor VIII:C levels and 1.8 (0.6-5.3) for high TAFI levels.
|
12368162 |
2002 |
Venous Thromboembolism
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Familial clustering of high factor VIII levels in patients with venous thromboembolism.
|
11156867 |
2001 |
Venous Thromboembolism
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
High factor VIII levels increase the risk of venous thromboembolism, but the mechanisms that cause high factor VIII levels are unclear.
|
11722428 |
2001 |
Venous Thromboembolism
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
We concluded that high factor VIII:C levels, probably in the effect of vWF, play a determinant role in worsening the APC-resistance phenotype and represent a common additional risk factor for VTE in heterozygous carriers of the factor V Leiden mutation.
|
10695766 |
1999 |
Venous Thromboembolism
|
0.100 |
GeneticVariation
|
phenotype |
BEFREE |
Here we have analysed 125 consecutive patients with incidental or recurrent venous thromboembolism for the presence of mutations at the cleavage sites for APC at amino acid positions Arg336 and Arg562 of factor VIII.
|
8616046 |
1996 |