Parkinson Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
It is proposed that in PD, binding of Cu(II) ions to ceruloplasmin is reduced and free copper ions coordinate with low molecular weight ligands.
|
31733982 |
2020 |
Parkinson Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Second, Chelex 100 treatment revealed that pPD ceruloplasmin compared with ceruloplasmin of healthy individuals displayed smaller content of labile copper atoms.
|
29203265 |
2018 |
Parkinson Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Ceruloplasmin in Parkinson's disease and the nonmotor symptoms.
|
29733522 |
2018 |
Parkinson Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Previous studies showed that CP deficiency contributes to Parkinson's disease by increasing iron accumulation and oxidative stress in the substantia nigra.
|
28874056 |
2018 |
Parkinson Disease
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We have previously demonstrated that reduced serum ceruloplasmin level exacerbates nigral iron deposition in Parkinson's disease, although the underlying cause of the low serum ceruloplasmin level in Parkinson's disease remains unknown.
|
30243884 |
2018 |
Parkinson Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Serum Ceruloplasmin and Striatal Dopamine Transporter Density in Parkinson Disease: Comparison With 123I-FP-CIT SPECT.
|
28632695 |
2017 |
Parkinson Disease
|
0.400 |
Biomarker
|
disease |
CTD_human |
High-density comparative genomic hybridization microarrays were also used to detect large-scale copy-number variations in CP and an additional 47 genes involved in PD and/or copper/iron metabolism.
|
25758665 |
2015 |
Parkinson Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
High-density comparative genomic hybridization microarrays were also used to detect large-scale copy-number variations in CP and an additional 47 genes involved in PD and/or copper/iron metabolism.
|
25758665 |
2015 |
Parkinson Disease
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
MiR-133b expression was correlated with the ceruloplasmin level in patients with PD, whereas no correlation was found between miR-133b and disease severity or motor phenotype.
|
25218846 |
2014 |
Parkinson Disease
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
These findings suggest that nigral iron deposition, correlating with decreased serum ceruloplasmin levels, is a risk factor in Parkinson's disease across multiple motor phenotypic expressions.
|
22288465 |
2012 |
Parkinson Disease
|
0.400 |
AlteredExpression
|
disease |
LHGDN |
A significantly decreased ferroxidase activity was found in PD, HD and AD, agreeing with findings of iron deposition in these entities, while free copper was found to be increased in CSF and appeared to be a good biomarker of PD.
|
18307039 |
2008 |
Parkinson Disease
|
0.400 |
Biomarker
|
disease |
CTD_human |
Mode of onset and duration of PD showed no relationship to ceruloplasmin.
|
19159062 |
2008 |
Parkinson Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Screening of genes involved in brain iron metabolism showed a significant association of some sequence variations of the ceruloplasmin gene with PD.
|
16755382 |
2006 |
Parkinson Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Moreover, variations in the ceruloplasmin gene were found to be associated with PD or SN hyperechogenicity.
|
16464747 |
2006 |
Parkinson Disease
|
0.400 |
AlteredExpression
|
disease |
LHGDN |
Our studies indicate that altered activity of ceruloplasmin may present a vulnerability factor for iron induced oxidative stress in PD.
|
16150804 |
2005 |
Parkinson Disease
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Our studies indicate that altered activity of ceruloplasmin may present a vulnerability factor for iron induced oxidative stress in PD.
|
16150804 |
2005 |
Parkinson Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Immunohistochemistry of PD midbrains was performed to examine the presence of Cp in Lewy bodies.
|
15557511 |
2004 |
Parkinson Disease
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In 1987, Miyajima et al. first characterized an autosomal recessive, adult-onset neurodegenerative disorder resembling Parkinson's disease associated with near-absent circulating serum ceruloplasmin levels.
|
15105274 |
2004 |
Parkinson Disease
|
0.400 |
Biomarker
|
disease |
LHGDN |
Immunohistochemistry of PD midbrains was performed to examine the presence of Cp in Lewy bodies.
|
15557511 |
2004 |