|
Pancreatitis
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
The mechanism by which CPA1 variants confer increased pancreatitis risk may involve misfolding-induced endoplasmic reticulum stress rather than elevated trypsin activity, as is seen with other genetic risk factors for this disease.
|
23955596 |
2013 |
|
Congenital Heart Defects
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Although this pathology usually is associated with genetic syndromes and other cardiac abnormalities, patients with CPA generally are asymptomatic.
|
23660850 |
2013 |
|
Hereditary pancreatitis
|
0.510 |
SusceptibilityMutation
|
disease |
ORPHANET |
Genetics of pancreatitis: the 2014 update.
|
24522117 |
2014 |
|
Adenoma
|
0.020 |
GeneticVariation
|
group |
BEFREE |
In addition, MT-3 immunohistochemistry was performed in non-pathological adrenal glands (NA: 19), idiopathic hyperaldosteronism (IHA: 10), APA (20), CPA (24), adjacent non-neoplastic adrenal glands of adenoma (AAG: 20), and adrenocortical carcinoma (ACC: 8).
|
24242700 |
2014 |
|
Pancreatitis
|
0.020 |
Biomarker
|
disease |
BEFREE |
In 2013, carboxypeptidase A1 (CPA1) was identified as a novel pancreatitis susceptibility gene.
|
24522117 |
2014 |
|
Conn Adenoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
The mRNA levels of MT-3 were first evaluated by quantitative RT-PCR (qPCR) in adrenocortical aldosterone-producing adenoma (APA: 11) and cortisol-producing adenoma (CPA: 14).
|
24242700 |
2014 |
|
Adrenocortical carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In addition, MT-3 immunohistochemistry was performed in non-pathological adrenal glands (NA: 19), idiopathic hyperaldosteronism (IHA: 10), APA (20), CPA (24), adjacent non-neoplastic adrenal glands of adenoma (AAG: 20), and adrenocortical carcinoma (ACC: 8).
|
24242700 |
2014 |
|
TROPICAL CALCIFIC PANCREATITIS
|
0.010 |
Biomarker
|
disease |
BEFREE |
Several studies have shown that, rather than mutations in trypsinogens, variants in serine protease inhibitor kazal type 1, cathepsin B, chymotrypsin C, cystic fibrosis transmembrane regulator, and carboxypeptidase A1, predict risk of TCP.
|
25516642 |
2014 |
|
Pancreatitis, Chronic
|
0.630 |
GeneticVariation
|
disease |
BEFREE |
Genetic alterations in the carboxypeptidase A1 gene (CPA1) are associated with early onset chronic pancreatitis (CP).
|
26316592 |
2015 |
|
Pancreatitis, Chronic
|
0.630 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
Genetic risk in chronic pancreatitis: the misfolding-dependent pathway.
|
28650851 |
2017 |
|
Pancreatitis, Chronic
|
0.630 |
Biomarker
|
disease |
BEFREE |
The best characterized misfolding variants in the highly expressed digestive proteases cationic trypsinogen (PRSS1) and carboxypeptidase A1 (CPA1) are strong, causative risk factors for chronic pancreatitis and may be associated with autosomal dominant hereditary pancreatitis.
|
28650851 |
2017 |
|
Hereditary pancreatitis
|
0.510 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
Genetic risk in chronic pancreatitis: the misfolding-dependent pathway.
|
28650851 |
2017 |
|
Polycystic Ovary Syndrome
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
When manually reviewing patient records for a sample of CPA/EE new users (n=200), the acne was recorded in 77% of women, hirsutism in 9.5% and polycystic ovary syndrome in 9.5%.
|
27769766 |
2017 |
|
Dehydration
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
The addition of protective compounds was also tested to improve survival of CPA-1 during the dehydration process.
|
28942462 |
2017 |
|
Aphakia, congenital primary
|
0.020 |
Biomarker
|
disease |
BEFREE |
A subset of 20 biopsy specimens was analyzed using digital imaging analysis (DIA) for the measurement of CPA (DIA-CPA).
|
28340131 |
2017 |
|
Aphakia, congenital primary
|
0.020 |
Biomarker
|
disease |
BEFREE |
Hypothermia induced by CPA was much greater than that caused by CGS21680 or IB-MECA indicating that A1AR activation is the major receptor-dependent pathway for adenosine-induced hypothermia under our experimental conditions.
|
27975140 |
2017 |
|
Meningioma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Meningioma involving internal auditory canal was only seen in one of the six patients with CPA meningioma.One tumor was totally ossified.
|
28247112 |
2017 |
|
Mycoses
|
0.010 |
Biomarker
|
group |
BEFREE |
The conspicuous presence of CPA and its numerous derivatives in <i>A. flavus</i> cultures raises concerns about the long-term and cumulative toxicological effects of these fungal secondary metabolites and their contributions to the entire <i>A. flavus</i> mycotoxin problem.
|
28098779 |
2017 |
|
Inflammatory pain
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
In addition, mechanical hyperalgesia was significantly reduced in the N6-cyclopentyladenosine (CPA) i.p. or i.m. and endomorphin (EM) i.p. groups.Neither EM i.m. nor EM i.p. exhibited any analgesic effect on thermal hyperalgesia.However, both CPA i.m. and CPA i.p. attenuated thermal hyperalgesia in the mouse inflammatory pain model.
|
29142219 |
2017 |
|
Adult Meningioma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Meningioma involving internal auditory canal was only seen in one of the six patients with CPA meningioma.One tumor was totally ossified.
|
28247112 |
2017 |
|
Idiopathic chronic pancreatitis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Herein we performed targeted next-generation sequencing of the CPA1 gene in 1,112 Han Chinese idiopathic chronic pancreatitis (ICP) patients-the largest ICP cohort so far analyzed in a single population-and 1,580 controls.
|
28497564 |
2017 |
|
Induced hypothermia (finding)
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Hypothermia induced by CPA was much greater than that caused by CGS21680 or IB-MECA indicating that A1AR activation is the major receptor-dependent pathway for adenosine-induced hypothermia under our experimental conditions.
|
27975140 |
2017 |
|
Meningioma, benign, no ICD-O subtype
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Meningioma involving internal auditory canal was only seen in one of the six patients with CPA meningioma.One tumor was totally ossified.
|
28247112 |
2017 |
|
Mechanical Allodynia
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
In addition, mechanical hyperalgesia was significantly reduced in the N6-cyclopentyladenosine (CPA) i.p. or i.m. and endomorphin (EM) i.p. groups.Neither EM i.m. nor EM i.p. exhibited any analgesic effect on thermal hyperalgesia.However, both CPA i.m. and CPA i.p. attenuated thermal hyperalgesia in the mouse inflammatory pain model.
|
29142219 |
2017 |
|
Nonalcoholic Steatohepatitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Sixty-five consecutive biopsy specimens from patients with mixed liver disease etiologies were assessed by three pathologists using the Ishak and nonalcoholic steatohepatitis Clinical Research Network (NASH CRN) scoring systems, and the fibrosis area (collagen proportionate area [CPA]) was estimated by visual inspection (visual-CPA).
|
28340131 |
2017 |