|
Carcinogenesis
|
0.090 |
AlteredExpression
|
phenotype |
BEFREE |
Similarly, cellular invasiveness, metastatic potential and prognosis are usually associated to claudin-4, -6, -7 and -9 expression in gastric carcinogenesis.
|
29031421 |
2018 |
|
Carcinogenesis
|
0.090 |
AlteredExpression
|
phenotype |
BEFREE |
However, the molecular mechanism of the upregulation of Claudin-4 and its role in lung tumorigenesis are unknown.
|
27424491 |
2016 |
|
Carcinogenesis
|
0.090 |
Biomarker
|
phenotype |
BEFREE |
For the in vivo tumorigenesis analysis, MCF-7 cells with or without claudin-4 silencing were transplanted into nude mice.
|
26058359 |
2015 |
|
Carcinogenesis
|
0.090 |
Biomarker
|
phenotype |
BEFREE |
Derepression of CLDN3 and CLDN4 during ovarian tumorigenesis is associated with loss of repressive histone modifications.
|
20053926 |
2010 |
|
Carcinogenesis
|
0.090 |
Biomarker
|
phenotype |
BEFREE |
In addition to potential new diagnostic markers (NEFM, CLDN4, PEROX2), the results point to genes that may be involved in the tumorigenesis (BEX1, TMEPAI, FOSL1, RAB32), and in the processes of invasion, progression and metastasis (MME, STAT3, DCBLD2) of NETs.
|
18827820 |
2008 |
|
Carcinogenesis
|
0.090 |
AlteredExpression
|
phenotype |
BEFREE |
To clarify the roles of claudins in endometrial tumorigenesis, we determined levels of protein and messengerRNA (mRNA) expression of claudin-3 and claudin-4 in human endometrial tissue (proliferative phase [PE, n= 25]; secretory phase [SE, n= 25]; simple hyperplasia [SH, n= 20]; complex hyperplasia [CH, n= 12]; atypical hyperplasia [AH, n= 15]; endometrioid adenocarcinoma [EEC, n= 30]) using immunohistochemistry, western blotting, and real-time polymerase chain reaction, respectively.
|
17291259 |
2007 |
|
Carcinogenesis
|
0.090 |
Biomarker
|
phenotype |
BEFREE |
Recent studies have suggested that claudin-1 (CLDN1) plays an important role in invasion and metastasis and claudin-4 (CLDN4) has a particular role in mammary glandular cell differentiation and carcinogenesis.
|
17611630 |
2007 |
|
Carcinogenesis
|
0.090 |
Biomarker
|
phenotype |
BEFREE |
Because CLDN4 is elevated in a large fraction of ovarian cancer, the mechanism leading to deregulation may represent a general pathway in ovarian tumorigenesis and may lead to novel strategies for therapy and an overall better understanding of the biology of this disease.
|
16714763 |
2006 |
|
Carcinogenesis
|
0.090 |
AlteredExpression
|
phenotype |
BEFREE |
The loss of CLDN4 expression in areas of apocrine metaplasia and in the majority of grade 1 invasive carcinomas also suggests a particular role for this protein in mammary glandular cell differentiation and carcinogenesis.
|
15743508 |
2005 |