|
Neoplasm Metastasis
|
0.300 |
AlteredExpression
|
phenotype |
BEFREE |
The expression levels of CLDN3 and CLDN7 were reported to be associated with distant metastasis and serve as potential predictors of poor prognosis.
|
31115553 |
2019 |
|
Neoplasm Metastasis
|
0.300 |
Biomarker
|
phenotype |
BEFREE |
This study demonstrated that DOCK1 mediates growth and motility through down-regulated claudin-1 expression via the RRP1BDNMTclaudin-1 pathway and that claudin-1 serves as an important effector in DOCK1-mediated cancer progression and metastasis in claudin-low breast cancer cells.
|
31717460 |
2019 |
|
Neoplasm Metastasis
|
0.300 |
Biomarker
|
phenotype |
BEFREE |
Overall, the results from the present study indicated that downregulating claudin-1 expression promoted the apoptosis of gallbladder cancer cells and inhibited cell invasion, indicating that claudin-1 may be involved in the recurrence and metastasis of gallbladder cancer.
|
30675228 |
2019 |
|
Neoplasm Metastasis
|
0.300 |
AlteredExpression
|
phenotype |
BEFREE |
Claudin-7 downregulation may promote the invasion and metastasis of CRC by regulating EMT.
|
30528239 |
2019 |
|
Neoplasm Metastasis
|
0.300 |
Biomarker
|
phenotype |
BEFREE |
Mouse model experiments were performed to confirm the effects of CLDN7 on tumor growth and metastasis in vivo.
|
30428910 |
2018 |
|
Neoplasm Metastasis
|
0.300 |
Biomarker
|
phenotype |
BEFREE |
Antrodia camphorata inhibits metastasis and epithelial-to-mesenchymal transition via the modulation of claudin-1 and Wnt/β-catenin signaling pathways in human colon cancer cells.
|
28688953 |
2017 |
|
Neoplasm Metastasis
|
0.300 |
AlteredExpression
|
phenotype |
BEFREE |
When E-cadherin was overexpressed in PC3-TxR and DU145-TxR cells, the expression of Vimentin and Claudin-1 was down-regulated, and tumor cell migration and invasion were inhibited.
|
28356132 |
2017 |
|
Neoplasm Metastasis
|
0.300 |
Biomarker
|
phenotype |
BEFREE |
Furthermore, knockdown of CLDN7 dramatically inhibited the metastasis and invasion of CNE2 cells suggesting that CLDN7 could act as a biomarker for NPC metastasis.Cycling hypoxia could induce significant changes in CLDN1 and CLDN7 expression in NPC cells.
|
28055967 |
2017 |
|
Neoplasm Metastasis
|
0.300 |
AlteredExpression
|
phenotype |
BEFREE |
In 68 TNBCs, we identified high Ki67 labeling index (LI) and the combination of CLDN4 high/CLDN7 low expression as independent predictors of axillary nodal metastasis (P = 0.019; OR, 4.36; 95%CI, 1.28-14.90 and P = 0.007; OR, 5.33; 95%CI, 1.58-17.90).
|
28699235 |
2017 |
|
Neoplasm Metastasis
|
0.300 |
Biomarker
|
phenotype |
BEFREE |
Lastly, WB showed that Claudin 1, Claudin 4, and Claudin 7 were closely related to tumour growth and metastasis.
|
28376864 |
2017 |
|
Neoplasm Metastasis
|
0.300 |
Biomarker
|
phenotype |
BEFREE |
Claudin-1 enhances tumor proliferation and metastasis by regulating cell anoikis in gastric cancer.
|
25544763 |
2015 |
|
Neoplasm Metastasis
|
0.300 |
AlteredExpression
|
phenotype |
BEFREE |
High expression of claudin-1 might induce the generation of tumor lymphatic vessels, which increases metastasis in the lymph node.
|
26436506 |
2015 |
|
Neoplasm Metastasis
|
0.300 |
Biomarker
|
phenotype |
BEFREE |
The importance of claudin-7 palmitoylation on membrane subdomain localization and metastasis-promoting activities.
|
26054340 |
2015 |
|
Neoplasm Metastasis
|
0.300 |
AlteredExpression
|
phenotype |
BEFREE |
CLAUDIN-1 immuno-staining showed loss of membrane expression and increased nuclear CLAUDIN-1 localization in FTC metastases.
|
26219679 |
2015 |
|
Neoplasm Metastasis
|
0.300 |
AlteredExpression
|
phenotype |
BEFREE |
Thus, our data suggest that miR-155 plays an important role in promoting CRC cell migration and invasion, at least in part through the regulation of claudin-1 expression and controlling metastasis in CRC.
|
23588589 |
2013 |
|
Neoplasm Metastasis
|
0.300 |
AlteredExpression
|
phenotype |
BEFREE |
These results suggest that loss of claudin-7 expression is associated closely with invasion and lymph metastasis and is an unfavorable prognostic factor in patients with OSCC.
|
23229436 |
2013 |
|
Neoplasm Metastasis
|
0.300 |
Biomarker
|
phenotype |
RGD |
EpCAM-associated claudin-7 supports lymphatic spread and drug resistance in rat pancreatic cancer.
|
23390083 |
2013 |
|
Neoplasm Metastasis
|
0.300 |
Biomarker
|
phenotype |
BEFREE |
Claudin-1 is a metastasis suppressor and correlates with clinical outcome in lung adenocarcinoma.
|
18787218 |
2009 |
|
Neoplasm Metastasis
|
0.300 |
AlteredExpression
|
phenotype |
LHGDN |
Our results suggested that a reduced expression of the claudin-7 gene might lead to venous invasion and liver metastasis in colorectal cancer.
|
18357381 |
2008 |
|
Neoplasm Metastasis
|
0.300 |
AlteredExpression
|
phenotype |
BEFREE |
Manipulation of claudin-1 levels in colon cancer cells showed a positive correlation between claudin-1 expression and tumor growth and metastasis.
|
17308096 |
2007 |
|
Neoplasm Metastasis
|
0.300 |
AlteredExpression
|
phenotype |
BEFREE |
Furthermore, we demonstrate that changes in claudin-1 expression have significant effects on growth of xenografted tumors and metastasis in athymic mice.
|
15965503 |
2005 |