Impaired cognition
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In addition, PDE4 inhibitors can also directly enhance network plasticity and attenuate degenerative processes and cognitive dysfunction by increasing activity of the canonical cAMP/phosphokinase-A/cAMP Responsive Element Binding protein (cAMP/PKA/CREB) plasticity pathway.
|
31660837 |
2020 |
Impaired cognition
|
0.100 |
Biomarker
|
disease |
BEFREE |
GW9508 ameliorates cognitive impairment via the cAMP-CREB and JNK pathways in APPswe/PS1dE9 mouse model of Alzheimer's disease.
|
31809762 |
2020 |
Impaired cognition
|
0.100 |
Biomarker
|
disease |
BEFREE |
A more thorough understanding of systemic dysregulation of CREB in AD will facilitate the search for a biomarker of cognitive function in AD, and also aid in the understanding of the mechanisms underlying cognitive decline in AD.
|
30641141 |
2019 |
Impaired cognition
|
0.100 |
Biomarker
|
disease |
BEFREE |
Overall, PTS protects neurons against Aβ-induced neurotoxicity and cognitive dysfunction through regulating the PDE4A-CREB-BDNF pathway.
|
31737188 |
2019 |
Impaired cognition
|
0.100 |
Biomarker
|
disease |
BEFREE |
The key findings of the present study demonstrated that CREB1 gene silencing results in aggravated VD that occurs as a result of inhibiting the PKA-CREB signaling pathway, thus exasperating cognitive dysfunction.
|
30134805 |
2018 |
Impaired cognition
|
0.100 |
Biomarker
|
disease |
BEFREE |
Importantly, hippocampal cyclic adenosine monophosphate (cAMP), p-PKA, p-CREB and BDNF levels were significantly increased in the APP/PS1 mice after RJ treatment, indicating that the cAMP/PKA/CREB/BDNF pathway might be related to the ameliorative effect of RJ on cognitive decline.
|
30687079 |
2018 |
Impaired cognition
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Administration of rolipram improved the memory deficits with concomitant recovery of cAMP and phosphorylated CREB levels, suggesting that reduced cAMP/CREB signaling in the DG leads to cognitive impairment in MPTP-treated mice.
|
28456375 |
2017 |
Impaired cognition
|
0.100 |
Biomarker
|
disease |
BEFREE |
Taken together, our data demonstrated that the reversal effect of FFPM on cognitive deficits in APP/PS1 transgenic mice might be related to stimulation of the cAMP/PKA/CREB/BDNF pathway and anti-inflammatory effects.
|
28065587 |
2017 |
Impaired cognition
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Preliminary investigation of the influence of CREB1 gene polymorphisms on cognitive dysfunction in Chinese patients with major depression.
|
23844928 |
2014 |
Impaired cognition
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Extremely low frequency electromagnetic field exposure causes cognitive impairment associated with alteration of the glutamate level, MAPK pathway activation and decreased CREB phosphorylation in mice hippocampus: reversal by procyanidins extracted from the lotus seedpod.
|
25066354 |
2014 |
Impaired cognition
|
0.100 |
Biomarker
|
disease |
BEFREE |
We also discuss the development of novel therapeutic strategies based on CREB targeting to ameliorate cognitive decline in aging and cognitive disorders.
|
21476939 |
2011 |
Impaired cognition
|
0.100 |
Biomarker
|
disease |
BEFREE |
Finally, we will discuss novel therapeutic approaches targeted to CBP/CREB function for treating the cognitive dysfunction of RTS and other neurological disorders.
|
16786226 |
2006 |