ATF2, activating transcription factor 2, 1386

N. diseases: 122; N. variants: 17
Disease: Hepatitis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0019158
Disease: Hepatitis
Hepatitis 		0.010 Biomarker group BEFREE The up-regulation of HMGB1 was thought to be modified by dual channels: in the transcriptional level, it was regulated by JNK1/JNK2-ATF2 axis; post-transcriptionally, it was regulated by the microRNA (miR)-200 family, especially miR-429. miR-429 liver conditional knockout mice (miR-429<sup>Δhep</sup>), fed either a normal diet or an HFD, showed severe liver inflammation and dysfunction, accompanied by greater expression of HMGB1. 29298863 2018