|
Irritable Bowel Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
<b>Abbreviations</b>: 5-HT: 5-hydroxytryptamine/serotonin; BDNF: brain-derived neurotrophic factor; CRF: corticotrophin-releasing factor; EC: enterochromaffin; ENS: enteric nervous system; GI: gastrointestinal; GPCR: G-protein-coupled receptor; IBS (-D): irritable bowel syndrome (diarrhea predominant); LRP5/6: low-density lipoprotein receptor-related protein 5/6; MAPK: mitogen-activated protein kinase; NGF: nerve growth factor; NMS: neonatal-maternal separation; PI3K: phosphoinositode3-kinase; PLCγ: phospholipase c, gamma subtype; TrkA: tropomyosin receptor kinase A.
|
31272268 |
2019 |
|
Diarrhea
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
<b>Abbreviations</b>: 5-HT: 5-hydroxytryptamine/serotonin; BDNF: brain-derived neurotrophic factor; CRF: corticotrophin-releasing factor; EC: enterochromaffin; ENS: enteric nervous system; GI: gastrointestinal; GPCR: G-protein-coupled receptor; IBS (-D): irritable bowel syndrome (diarrhea predominant); LRP5/6: low-density lipoprotein receptor-related protein 5/6; MAPK: mitogen-activated protein kinase; NGF: nerve growth factor; NMS: neonatal-maternal separation; PI3K: phosphoinositode3-kinase; PLCγ: phospholipase c, gamma subtype; TrkA: tropomyosin receptor kinase A.
|
31272268 |
2019 |
|
Regular astigmatism - corneal
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
<b>Abbreviations:</b> ICRS: intrastromal corneal ring segments; UDVA: uncorrected distance visual acuity; CDVA: corrected distance visual acuity; logMAR: logarithm of minimum angle of resolution; SE: spherical equivalent; IOP: intra-ocular pressure; Km: mean keratometry; CA: corneal astigmatism; WTR: with-the-rule; ATR: against-the-rule; OBL: oblique; SB: symmetric bow-tie; AB: asymmetric bow-tie; IS: inferior steepening; SRAX: skewed radial axis; Q: asphericity (<i>Q</i>-value); CCT: central corneal thickness; CTP: corneal thinnest point; ORA: ocular response analyzer; CH: corneal hysteresis; CRF: corneal resistance factor; HOAs: higher-orders aberrations; RMS: root mean square; SD: standard deviation; CI: confidence interval.
|
30868919 |
2019 |
|
Medullary carcinoma of thyroid
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
(1) This first comparison between somatostatin receptor status in vivo and ex vivo in MTC shows a marked positive octreoscan despite absent SSTR 2 expression, and (2) this is the first report of a discrepancy between immunostaining and gene transcription for POMC and CRH.
|
12053094 |
2002 |
|
Epilepsy, Frontal Lobe
|
0.010 |
GeneticVariation
|
disease |
LHGDN |
Frontal lobe epilepsy and mutations of the corticotropin-releasing hormone gene.
|
16222669 |
2005 |
|
Autosomal Dominant Nocturnal Frontal Lobe Epilepsy
|
0.330 |
GeneticVariation
|
disease |
BEFREE |
Autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE; MIM 600513) has been associated with mutations in the genes coding for the alfa-4 (CHRNA4), beta-2 (CHRNB2), and alpha-2 (CHRNA2) subunits of the neuronal nicotinic acetylcholine receptor (nAChR) and for the corticotropin-releasing hormone (CRH).
|
17900292 |
2008 |
|
Hyperactive behavior
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Hyperactivity of corticotropin-releasing factor (CRF) neurons in the paraventricular nucleus (PVN) of the hypothalamus is a prominent feature in depression and may be important in the etiology of this disease.
|
18427561 |
2008 |
|
Alcoholic Intoxication, Chronic
|
0.390 |
Biomarker
|
disease |
PSYGENET |
Alcohol dependence is associated with increased corticotropin releasing factor (CRF) influence on CeA GABA release and CRF type 1 receptor (CRF(1)) antagonists prevent the excessive alcohol consumption associated with dependence.
|
23220399 |
2013 |
|
Stress, Psychological
|
0.100 |
Biomarker
|
disease |
BEFREE |
Psychological stress-derived CRF can breach the established endotoxin tolerance in the intestinal mucosa.
|
23840363 |
2013 |
|
Chest Pain
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Chest pain after intravenous corticotropin-releasing hormone.
|
2563132 |
1989 |
|
Hyperactive behavior
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
Hyperactivity of the hypothalamic-pituitary-adrenal axis (HPA) and impairment of the central corticotropin-releasing factor (CRF) system are factors in the pathogenesis of depression.
|
28429110 |
2017 |
|
Addison Disease
|
0.060 |
Biomarker
|
disease |
BEFREE |
Addison's disease concomitant with corticotropin deficiency and pituitary CRH resistance - a case report.
|
28819949 |
2017 |
|
Endometriosis
|
0.050 |
Biomarker
|
disease |
BEFREE |
Endometriosis increased CRH and GR only in the vesicles of endo-NE, and this increase was dampened in the endo-EE.
|
29137551 |
2018 |
|
Secondary Adrenal Insufficiency
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Central adrenal insufficiency (CAI) is a life-threatening condition caused by either pituitary disease (secondary adrenal insufficiency) or impaired hypothalamic function with inadequate CRH production (tertiary adrenal insufficiency).
|
30086867 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Neoplasms associated with CS exhibit strong immunoreactivity for both hormones, suggesting that CRH probably plays a role in the pathogenesis of CS.
|
30502716 |
2019 |
|
Rheumatoid Arthritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
CRH mRNA was up-regulated in the synovial tissue in rheumatoid arthritis (RA), psoriatic arthritis (PsA), and sarcoid arthritis, but not in normal synovium.
|
11315917 |
2001 |
|
Arthritis, Psoriatic
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
CRH mRNA was up-regulated in the synovial tissue in rheumatoid arthritis (RA), psoriatic arthritis (PsA), and sarcoid arthritis, but not in normal synovium.
|
11315917 |
2001 |
|
Sarcoid arthritis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
CRH mRNA was up-regulated in the synovial tissue in rheumatoid arthritis (RA), psoriatic arthritis (PsA), and sarcoid arthritis, but not in normal synovium.
|
11315917 |
2001 |
|
Anxiety Disorders
|
0.400 |
Biomarker
|
group |
CTD_human |
CRF elicited a wide range of behaviors, which fell into three broad categories: anxiety-like, depressive-like, and externally oriented.
|
12438692 |
2002 |
|
Unipolar Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
CRH, stress, and major depression: a psychobiological interplay.
|
15196881 |
2004 |
|
Seizures
|
0.320 |
Biomarker
|
phenotype |
CTD_human |
Corticotropin-releasing hormone-induced electrographic and behavioral seizures originate in the amygdala.
|
1596084 |
1992 |
|
Mental Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
CRF overproduction has been implicated in affective disorders, such as depression and anorexia nervosa, and may lead to Cushing's syndrome.
|
1597149 |
1992 |
|
Depressive disorder
|
0.600 |
Biomarker
|
disease |
BEFREE |
CRF overproduction has been implicated in affective disorders, such as depression and anorexia nervosa, and may lead to Cushing's syndrome.
|
1597149 |
1992 |
|
Depressed mood
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
CRF overproduction has been implicated in affective disorders, such as depression and anorexia nervosa, and may lead to Cushing's syndrome.
|
1597149 |
1992 |
|
Anorexia Nervosa
|
0.040 |
Biomarker
|
disease |
BEFREE |
CRF overproduction has been implicated in affective disorders, such as depression and anorexia nervosa, and may lead to Cushing's syndrome.
|
1597149 |
1992 |