Mental Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
CRF overproduction has been implicated in affective disorders, such as depression and anorexia nervosa, and may lead to Cushing's syndrome.
|
1597149 |
1992 |
Mental Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
These data indicate that CRF receptor antagonists may be useful for the treatment of the disease states where CRF is elevated such as anxiety and depression, anorexia nervosa and stroke and that ligand inhibitors of CRF-BP may be used to elevate brain levels of 'free' urocortin and other CRF-related peptides.
|
9118350 |
1996 |
Mental Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
Abnormalities in CRH secretion have been documented in both the depression and manic phases of bipolar disorder (BPD).
|
9399692 |
1998 |
Mental Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
More refined analysis of the HPA system revealed that corticosteroid receptor (CR) signaling is impaired in major depression, resulting among other changes, in increased production and secretion of corticotropin-releasing hormone (CRH, also frequently abbreviated CRF) in various brain regions postulated to be involved in the causality of depression.
|
11027914 |
2000 |
Mental Depression
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Levels of corticotropin-releasing hormone are elevated in patients with depression and anxiety and are expected to be elevated in patients with congenital adrenal hyperplasia; it is unknown whether patients with 21-hydroxylase deficiency have an increased incidence of these psychiatric disorders.
|
11848730 |
2002 |
Mental Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
The Dex/CRH test is one of the most reliable neuroendocrine function tests for hypothalamic-pituitary-adrenocortical (HPA) system dysregulation in depression.
|
12147330 |
2002 |
Mental Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
These findings raise the possibility that the CRH and GABA(A) receptor subunit changes, or the disturbed coordination between these GABA(A) receptor subunits, contribute to depression and/or suicidality or are secondary to the illness/distress associated with it.
|
14960621 |
2004 |
Mental Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
Because both cortisol and CRH have behavioral effects, and hypothalamic CRH hypersecretion has been associated with chronic states of anxiety and depression, we performed endocrine and psychologic studies in consecutively admitted parents of patients with classic congenital adrenal hyperplasia due to 21-OH deficiency and parents of children with other chronic endocrine disorders.
|
15126546 |
2004 |
Mental Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
There are well-replicated, independent lines of evidence supporting a role for corticotropin-releasing hormone (CRH) in the pathophysiology of depression.
|
15365580 |
2004 |
Mental Depression
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Numerous reports suggest that alterations in CRF function contribute to the pathogenesis of depression.
|
16122764 |
2006 |
Mental Depression
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Early-life adversity, such as physical or sexual abuse during childhood, results in long-lasting changes in the CRF-mediated stress response and a greatly increased risk of depression in genetically predisposed persons.
|
16124836 |
2005 |
Mental Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
Corticotropin-releasing factor, vasopressin and receptor systems in depression and anxiety.
|
16733617 |
2006 |
Mental Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
Corticotropin-releasing hormone (CRH) has been implicated in the pathophysiology of anxiety disorders and depression.
|
16884458 |
2006 |
Mental Depression
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Child abuse and trauma alter the endogenous stress response, principally corticotropin-releasing hormone and its downstream effectors, suggesting that a gene x environment interaction at this locus may be important in depression.
|
18250257 |
2008 |
Mental Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
Indeed, animal studies have shown that vulnerability to depressive-like behaviors involve mechanisms similar to those associated with human depression (e.g., altered serotonin, corticotropin releasing hormone and their receptors, growth factors), and that the effects of stressors are influenced by previous stressor experiences, particularly those encountered early in life.
|
18423590 |
2008 |
Mental Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
Hyperactivity of corticotropin-releasing factor (CRF) neurons in the paraventricular nucleus (PVN) of the hypothalamus is a prominent feature in depression and may be important in the etiology of this disease.
|
18427561 |
2008 |
Mental Depression
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Variation in the corticotropin-releasing hormone receptor (CRHR1) gene has been shown to interact with early life stress to predict adult depression.
|
19596121 |
2009 |
Mental Depression
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
These results suggest that RAR-alpha might contribute to regulating the activity of CRH neurons in vivo, and the vulnerable character of the critical proteins in RA signaling pathways might provide novel targets for therapeutic strategies for depression.
|
19596122 |
2009 |
Mental Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
REST has many target genes, including corticotropin releasing hormone (CRH), brain-derived neurotrophic factor, serotonin 1A receptor, which are suggested to be involved in the pathophysiology of depression and the action of antidepressants.
|
19846118 |
2010 |
Mental Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
A concatenation of findings from preclinical and clinical studies support a preeminent function for the corticotropin-releasing factor (CRF) system in mediating the physiological response to external stressors and in the pathophysiology of anxiety and depression.
|
20010888 |
2010 |
Mental Depression
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Corticotropin-releasing factor (CRF) has a key role in the central stress response, and altered levels of this neuropeptide are linked to stress-related psychopathologies such as anxiety and depression.
|
20548294 |
2011 |
Mental Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
In the present study we investigate whether the two forms of dendritic cell nuclear protein-1 might act on corticotropin-releasing hormone, which plays a crucial role in the stress response and in the pathogenesis of depression.
|
20693543 |
2010 |
Mental Depression
|
0.600 |
Biomarker
|
disease |
RGD |
Alterations in the central CRF system of two different rat models of comorbid depression and functional gastrointestinal disorders.
|
20860876 |
2011 |
Mental Depression
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Recently, two studies have reported an interaction between childhood abuse and the TAT-haplotype of the CRH-Receptor Gene (CRHR1) connecting childhood adversities and genetic susceptibility to adult depression.
|
20957648 |
2010 |
Mental Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
In addition, elevated CRF in cerebrospinal fluid is observed in mood and anxiety disorder patients, suggesting that CRF is also being overproduced from extrahypothalamic sources such as the central amygdala (CeA) and overactivity of the amygdala in neuroimaging studies is a consistent finding in anxiety and depression patients.
|
21616602 |
2012 |