Mental Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
Gross anatomical abnormalities (volume changes of the third ventricle, the hypothalamus, and its nuclei) and alterations at the cellular level (loss of neurons, increased or decreased expression of hypothalamic peptides such as oxytocin, vasopressin, corticotropin-releasing hormone, and other regulatory factors as well as of enzymes involved in neurotransmitter and neuropeptide metabolism) have been reported in schizophrenia and/or depression.
|
29767278 |
2019 |
Mental Depression
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Hypothalamic insulin and glucagon-like peptide-1 levels in an animal model of depression and their effect on corticotropin-releasing hormone promoter gene activity in a hypothalamic cell line.
|
30831439 |
2019 |
Mental Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
Dysregulation of the corticotropin-releasing hormone (CRH) system has been implicated in stress-related psychopathologies such as depression and anxiety.
|
31619956 |
2019 |
Mental Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
Studying the network of CRF and immune responses will help to enhance our understanding of the pathogenesis of depression.
|
31312123 |
2019 |
Mental Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
TC-IBS showed a pronounced depression phenotype with increased corticotropin-releasing hormone receptor (CRHR)1 and CRHR2 expression at the frontal cortex and increased serum ACTH concentration.
|
31570003 |
2019 |
Mental Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
Corticotropin-releasing factor binds with high affinity to CRF receptor 1 (CRFR1) and is implicated in stress-related mood disorders such as anxiety and depression.
|
30499109 |
2019 |
Mental Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
Specifically described are sex differences in receptors for the stress neuropeptide, corticotropin-releasing factor (CRF), that render the locus coeruleus arousal system of females more vulnerable to stress and less adaptable to CRF hypersecretion, a condition found in patients with PTSD and depression.
|
30022063 |
2019 |
Mental Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
Corticotropin-releasing hormone (CRH), produced by MCs, has been found in microglial cells where it regulates immune cells and contributes to the pathogenesis of neurodegenerative diseases including depression.
|
29907890 |
2018 |
Mental Depression
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
In the present study, we demonstrated that chronic FS stress (CFSS) could activate corticotropin-releasing factor (CRF)/CRF receptor type 1 (CRFR1) signaling in the BLA, and blockade of CRF/CRFR1 signaling by intra-BLA injection of NBI27914 (NBI), a selective CRFR1 antagonist, could prevent the CFSS-induced depressive-like behaviors in rats, indicating that activation of CRF/CRFR1 signaling in the BLA is required for CFSS-induced depression.
|
29080675 |
2018 |
Mental Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
The following search items were used: "hypothalamic-pituitary-adrenal" OR "HPA" OR "cortisol" OR "corticotropin releasing hormone" OR "corticotropin releasing factor" OR "glucocorticoid*" OR "adrenocorticotropic hormone" OR "ACTH" AND "atypical depression" OR "non-atypical depression" OR "melancholic depression" OR "non-melancholic depression" OR "endogenous depression" OR "endogenomorphic depression" OR "non-endogenous depression".
|
29150144 |
2018 |
Mental Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
Preclinical studies have shown that dysregulation of the corticotropin releasing factor (CRF) neurotransmission has been implicated in stress-related psychopathologies such as depression and anxiety, and may affect alcohol consumption.
|
29118713 |
2017 |
Mental Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
Serotonin, norepinephrine, dopamine, and trace amines, such as the "endogenous amphetamine" phenylethylamine, are increased in brain, which leads to changes in neuroplasticity by e.g. increased neurotrophic growth factors and translates to reduced stress-induced hypersecretion of corticotropin releasing factor (CRF) and positive testing in animal studies of depression.
|
28655495 |
2017 |
Mental Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
Both cortisol and CRH have behavioral effects, and hypothalamic CRH hypersecretion has been associated with chronic states of anxiety and depression.
|
28500827 |
2017 |
Mental Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
These findings suggest that the augmented glutamatergic and synaptic signaling might be a potential mechanism underlying CRH over-activation in the hypothalamic PVN and contribute to CUS-induced depression-like behaviors in rats.
|
28735061 |
2017 |
Mental Depression
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
The aim of our study was to assess the influence of SN003, a CRF<sub>1</sub> receptor blocker, on the activity of imipramine and fluoxetine in the forced swim test (FST) in rats which presented some signs of depression.
|
28429110 |
2017 |
Mental Depression
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
i) Compared to control subjects, the amount of hypocretin-immunoreactivity (ir) was significantly increased in female but not in male depression patients; ii) hypothalamic hypocretin-ir showed a clear diurnal fluctuation, which was absent in depression; iii) male depressive patients who had committed suicide showed significantly increased ACC Hcrt-receptor-2-mRNA expression compared to male controls; and iv) female but not male CUMS rats showed a highly significant positive correlation between the mRNA levels of corticotropin-releasing hormone and prepro-hypocretin in the hypothalamus, and a significantly increased Hcrt-receptor-1-mRNA expression in the frontal cortex compared to female control rats.
|
28377228 |
2017 |
Mental Depression
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Early life stress (ELS) is associated with increased vulnerability for depression, changes to the corticotropin-releasing hormone (CRH) system and structural and functional changes in hippocampus.
|
28461011 |
2017 |
Mental Depression
|
0.600 |
Biomarker
|
disease |
BEFREE |
Clinical application of DEX/CRH test and multi-channel NIRS in patients with depression.
|
27582123 |
2016 |
Mental Depression
|
0.600 |
Biomarker
|
disease |
PSYGENET |
Correlation analysis indicated that the alteration of multiple CRF-controlling receptors is highly correlated with depression-related behaviors of rats in the forced swimming test.
|
25578258 |
2015 |
Mental Depression
|
0.600 |
Biomarker
|
disease |
PSYGENET |
The corticotropin releasing hormone (CRH) and the CRH receptor 1 (CRHR1) have been implicated in the link between early life adversity and adult anxiety and depression, with rodent studies identifying the very early postnatal period as highly susceptible to this programming.
|
24630468 |
2014 |
Mental Depression
|
0.600 |
Biomarker
|
disease |
PSYGENET |
Sensitizing effect of early adversity on depressive reactions to later proximal stress: Moderation by polymorphisms in serotonin transporter and corticotropin releasing hormone receptor genes in a 20-year longitudinal study.
|
25422958 |
2014 |
Mental Depression
|
0.600 |
Biomarker
|
disease |
PSYGENET |
Because dysregulation of CRH expression occurs in stress-related disorders including depression, a full understanding of the complex regulation of this gene is important in both health and disease.
|
23768074 |
2014 |
Mental Depression
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Association of glucocorticoid and type 1 corticotropin-releasing hormone receptors gene variants and risk for depression during pregnancy and post-partum.
|
23726670 |
2013 |
Mental Depression
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, 5-HT2CR signaling enhancement and the subsequent activation of the CRF neuron were involved in novelty-induced hypophagia in aged mice, and the 5-HT2CR antagonists offer a promising therapeutic option for depression.
|
23583320 |
2013 |
Mental Depression
|
0.600 |
Biomarker
|
disease |
PSYGENET |
Association of glucocorticoid and type 1 corticotropin-releasing hormone receptors gene variants and risk for depression during pregnancy and post-partum.
|
23726670 |
2013 |