|
Irritable Bowel Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Plasma Corticotropin-Releasing Factor Receptors and B7-2⁺ Extracellular Vesicles in Blood Correlate with Irritable Bowel Syndrome Disease Severity.
|
30704133 |
2019 |
|
Irritable Bowel Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
These responses were demonstrated to be peripheral corticotropin-releasing factor (CRF) dependent and also mediated via proinflammatory cytokine in animal IBS model.
|
30935894 |
2019 |
|
Irritable Bowel Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Electroacupuncture Regulates Disorders of Gut-Brain Interaction by Decreasing Corticotropin-Releasing Factor in a Rat Model of IBS.
|
31737064 |
2019 |
|
Irritable Bowel Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
<b>Abbreviations</b>: 5-HT: 5-hydroxytryptamine/serotonin; BDNF: brain-derived neurotrophic factor; CRF: corticotrophin-releasing factor; EC: enterochromaffin; ENS: enteric nervous system; GI: gastrointestinal; GPCR: G-protein-coupled receptor; IBS (-D): irritable bowel syndrome (diarrhea predominant); LRP5/6: low-density lipoprotein receptor-related protein 5/6; MAPK: mitogen-activated protein kinase; NGF: nerve growth factor; NMS: neonatal-maternal separation; PI3K: phosphoinositode3-kinase; PLCγ: phospholipase c, gamma subtype; TrkA: tropomyosin receptor kinase A.
|
31272268 |
2019 |
|
Irritable Bowel Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
TC-IBS showed a pronounced depression phenotype with increased corticotropin-releasing hormone receptor (CRHR)1 and CRHR2 expression at the frontal cortex and increased serum ACTH concentration.
|
31570003 |
2019 |
|
Irritable Bowel Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
CRF induces the NLRP6-inflammatory cytokine axis in IBS mice.
|
30663229 |
2019 |
|
Irritable Bowel Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Negatively perceived adulthood life events were associated with reduced production of ACTH in response to corticotropin-releasing factor in patients with IBS compared with controls (P < .05).
|
30616026 |
2019 |
|
Irritable Bowel Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
CRF and receptors might be a key molecule involving the immune and movement function <i>via</i> brain-gut axis in IBS.
|
29483895 |
2018 |
|
Irritable Bowel Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Corticotropin-releasing factor (CRF) and immune-mediated mechanisms have been proposed to contribute to these changes in IBS, but the precise roles have not been determined.
|
30139928 |
2018 |
|
Irritable Bowel Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
We enrolled 32 patients with IBS (16 women and 16 men) and 32 healthy subjects (16 women and 16 men), and randomly divided them between CRH and saline injection groups.
|
29979696 |
2018 |
|
Irritable Bowel Syndrome
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
A negative association between ACTH response to CRH and activity in the pregenual anterior cingulate cortex (pACC) during rectal distention was identified in controls but not in IBS patients.
|
28963545 |
2017 |
|
Irritable Bowel Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Cytokeratin 8 (CK8), for the first time, has been shown to mediate corticotropin-releasing factor (CRF)-induced changes in intestinal permeability in animal models of IBS.
|
29179184 |
2017 |
|
Irritable Bowel Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Further studies on IBS and the CRH system are warranted.
|
26808377 |
2016 |
|
Irritable Bowel Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
We aimed to study the effects of IBS status, sex, or presence of early adverse life events (EAL) on the cortisol response to corticotropin-releasing factor (CRF) and adrenocorticotropic hormone (ACTH), and on GR mRNA expression in peripheral blood mononuclear cells (PBMCs).
|
27038676 |
2016 |
|
Irritable Bowel Syndrome
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Therefore, we tested our hypothesis that single-nucleotide polymorphisms (SNPs) in CRH-related genes influence the features of IBS.
|
26882083 |
2016 |
|
Irritable Bowel Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
To determine if CRH-R1 SNPs are associated with: (1) a diagnosis of IBS, (2) gastrointestinal (GI) symptoms, and (3) acoustic startle response (ASR) to threat, which is mediated by the amygdala via CRH.
|
27497153 |
2016 |
|
Irritable Bowel Syndrome
|
0.100 |
Biomarker
|
disease |
BEFREE |
Corticotropin-releasing hormone (CRH) acts mainly via the CRH receptor 1 (CRH-R1) and plays a crucial role in the stress-induced pathophysiology of irritable bowel syndrome (IBS).
|
22957021 |
2012 |